NL1006243C2 - Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam. - Google Patents

Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam. Download PDF

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Publication number
NL1006243C2
NL1006243C2 NL1006243A NL1006243A NL1006243C2 NL 1006243 C2 NL1006243 C2 NL 1006243C2 NL 1006243 A NL1006243 A NL 1006243A NL 1006243 A NL1006243 A NL 1006243A NL 1006243 C2 NL1006243 C2 NL 1006243C2
Authority
NL
Netherlands
Prior art keywords
methyl ester
acid
apm
protected
salt
Prior art date
Application number
NL1006243A
Other languages
English (en)
Dutch (nl)
Inventor
Wilhelmus Hubertus Jos Boesten
Jacob Van Soolingen
Original Assignee
Holland Sweetener Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co filed Critical Holland Sweetener Co
Priority to NL1006243A priority Critical patent/NL1006243C2/nl
Priority to DE69813801T priority patent/DE69813801T2/de
Priority to KR1019997011457A priority patent/KR20010013454A/ko
Priority to CN98807823A priority patent/CN1130371C/zh
Priority to JP50213299A priority patent/JP2002504905A/ja
Priority to PCT/NL1998/000296 priority patent/WO1998055503A1/en
Priority to EP98924673A priority patent/EP0986575B1/de
Application granted granted Critical
Publication of NL1006243C2 publication Critical patent/NL1006243C2/nl
Priority to US09/455,502 priority patent/US6245934B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)
NL1006243A 1997-06-06 1997-06-06 Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam. NL1006243C2 (nl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NL1006243A NL1006243C2 (nl) 1997-06-06 1997-06-06 Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam.
DE69813801T DE69813801T2 (de) 1997-06-06 1998-05-25 Verfahren zur herstellung von aspartamsalzen aus n-geschütztem aspartam
KR1019997011457A KR20010013454A (ko) 1997-06-06 1998-05-25 Ｎ-보호 아스파르탐으로부터 아스파르탐 염의 제조방법
CN98807823A CN1130371C (zh) 1997-06-06 1998-05-25 由n－保护的阿司帕坦制备阿司帕坦盐的方法
JP50213299A JP2002504905A (ja) 1997-06-06 1998-05-25 Ｎ−保護されたアスパルテームからアスパルテームの塩を製造する方法
PCT/NL1998/000296 WO1998055503A1 (en) 1997-06-06 1998-05-25 Method for preparing salts of aspartame from n-protected aspartame
EP98924673A EP0986575B1 (de) 1997-06-06 1998-05-25 Verfahren zur herstellung von aspartamsalzen aus n-geschütztem aspartam
US09/455,502 US6245934B1 (en) 1997-06-06 1999-12-06 Method for preparing salts of aspartame from N-protected aspartame

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1006243A NL1006243C2 (nl) 1997-06-06 1997-06-06 Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam.
NL1006243 1997-06-06

Publications (1)

Publication Number Publication Date
NL1006243C2 true NL1006243C2 (nl) 1998-12-08

Family

ID=19765110

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1006243A NL1006243C2 (nl) 1997-06-06 1997-06-06 Werkwijze voor de bereiding van zouten van aspartaam uit N-beschermd aspartaam.

Country Status (8)

Country Link
US (1) US6245934B1 (de)
EP (1) EP0986575B1 (de)
JP (1) JP2002504905A (de)
KR (1) KR20010013454A (de)
CN (1) CN1130371C (de)
DE (1) DE69813801T2 (de)
NL (1) NL1006243C2 (de)
WO (1) WO1998055503A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1009323C2 (nl) * 1998-06-05 1999-12-07 Holland Sweetener Co Bereiding en zuivering van een organisch zout van aspartaam.
NL1009324C2 (nl) * 1998-06-05 1999-12-07 Holland Sweetener Co Bereiding en zuivering van een organisch zout van aspartaam.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0582303A1 (de) * 1992-08-05 1994-02-09 Ajinomoto Co., Inc. Methode für die Produktion von Alpha-L-aspartyl-L-phenylalanin-methylester-hydrochlorid
EP0768041A1 (de) * 1995-10-11 1997-04-16 Holland Sweetener Company V.o.F. Süssstoffesaltzen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
DE2001017C3 (de) 1970-01-10 1978-05-18 Hoechst Ag, 6000 Frankfurt 3,4-Dihydro-1,23-oxathiazin-4on-2,2-dioxide, ihre Herstellung und Verwendung
GB2140805B (en) 1983-05-31 1986-08-13 Erba Farmitalia Isolation of aspartame
NL8701035A (nl) 1987-05-01 1988-12-01 Stamicarbon Werkwijze voor de bereiding van aspartylfenylalaninemethylester uit n-formylaspartylfenylalaninemethylester.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0582303A1 (de) * 1992-08-05 1994-02-09 Ajinomoto Co., Inc. Methode für die Produktion von Alpha-L-aspartyl-L-phenylalanin-methylester-hydrochlorid
EP0768041A1 (de) * 1995-10-11 1997-04-16 Holland Sweetener Company V.o.F. Süssstoffesaltzen

Also Published As

Publication number Publication date
CN1265667A (zh) 2000-09-06
EP0986575B1 (de) 2003-04-23
CN1130371C (zh) 2003-12-10
DE69813801D1 (de) 2003-05-28
WO1998055503A1 (en) 1998-12-10
US6245934B1 (en) 2001-06-12
JP2002504905A (ja) 2002-02-12
EP0986575A1 (de) 2000-03-22
KR20010013454A (ko) 2001-02-26
DE69813801T2 (de) 2004-01-22

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Effective date: 20020101