NI200700080A - Compuesto de 4-amino-sustituido-2-sustitiuido-1,2,3,4-tetrahidroquinolina. - Google Patents

Compuesto de 4-amino-sustituido-2-sustitiuido-1,2,3,4-tetrahidroquinolina.

Info

Publication number
NI200700080A
NI200700080A NI200700080A NI200700080A NI200700080A NI 200700080 A NI200700080 A NI 200700080A NI 200700080 A NI200700080 A NI 200700080A NI 200700080 A NI200700080 A NI 200700080A NI 200700080 A NI200700080 A NI 200700080A
Authority
NI
Nicaragua
Prior art keywords
substituted
cholesterol
levels
amino
tetrahydroquinoline
Prior art date
Application number
NI200700080A
Other languages
English (en)
Inventor
George Tetteh Magnus-Aryitey
Roger Benjamin Ruggeri
Ravi Mysore Shanker
Douglas Alan Lorenz
Thuma Benjamin Aaron
Cheryl Denise Garr
Mary Therese Didiuk
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35431286&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI200700080(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NI200700080A publication Critical patent/NI200700080A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de 4-amino sustituido-2-sustituido-1,2,3,4-tetrahidroquinolina, composiciones farmacéuticas que contienen tales compuestos y el uso de tales compuestos para elevar determinados niveles de lípidos en plasma, incluido lipoproteínas de alta densidad-colesterol, y para disminuir determinados otros niveles de lípidos en el plasma, tales como LDL-colesterol y triglicéridos y, por consiguiente, para tratar enfermedades que están exacerbadas por bajos niveles de HDL-colesterol y/o altos niveles de LDL-colesterol y triglicéridos, tales como aterosclerosis y enfermedades cardiovasculares en algunos mamíferos, incluidos seres humanos.
NI200700080A 2004-09-23 2007-03-21 Compuesto de 4-amino-sustituido-2-sustitiuido-1,2,3,4-tetrahidroquinolina. NI200700080A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61286004P 2004-09-23 2004-09-23
US65870405P 2005-03-03 2005-03-03
US11/187,854 US20060063803A1 (en) 2004-09-23 2005-07-25 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds

Publications (1)

Publication Number Publication Date
NI200700080A true NI200700080A (es) 2008-03-07

Family

ID=35431286

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200700080A NI200700080A (es) 2004-09-23 2007-03-21 Compuesto de 4-amino-sustituido-2-sustitiuido-1,2,3,4-tetrahidroquinolina.

Country Status (23)

Country Link
US (2) US20060063803A1 (es)
EP (1) EP1799648A1 (es)
JP (1) JP2008513537A (es)
KR (1) KR100857462B1 (es)
AR (1) AR053094A1 (es)
AU (1) AU2005286186A1 (es)
BR (1) BRPI0515906A (es)
CA (1) CA2581462A1 (es)
CR (1) CR9012A (es)
EA (1) EA200700479A1 (es)
EC (1) ECSP077333A (es)
GT (1) GT200500265A (es)
IL (1) IL181722A0 (es)
MA (1) MA28868B1 (es)
MX (1) MX2007003441A (es)
NI (1) NI200700080A (es)
NL (1) NL1030010C2 (es)
NO (1) NO20071510L (es)
PA (1) PA8646101A1 (es)
PE (1) PE20060820A1 (es)
TN (1) TNSN07100A1 (es)
TW (1) TW200616963A (es)
WO (1) WO2006033002A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003269327A1 (en) * 2002-10-21 2004-05-04 Warner-Lambert Company Llc Tetrahydroquinoline derivatives as crth2 antagonists
US20060270675A1 (en) * 2005-03-10 2006-11-30 Groneberg Robert D Inhibitors of cholesterol ester transfer protein
WO2007107843A1 (en) * 2006-03-22 2007-09-27 Pfizer Products Inc. Methods of treatment with cetp inhibitors
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
CN101910150B (zh) 2007-11-05 2013-09-18 诺瓦提斯公司 作为cetp抑制剂、可用于治疗疾病如高脂血症或动脉硬化的4-苄基氨基-1-羧基酰基哌啶衍生物
AU2012202172B2 (en) * 2007-11-05 2013-08-29 Novartis Ag 4-benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis
ES2375527T3 (es) * 2007-12-03 2012-03-01 Novartis Ag Derivados 1,2-disustituidos-4-bencilamino-pirrolidina como inhibidores cetp útiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis.
MX2014000342A (es) 2011-07-08 2014-05-01 Novartis Ag Metodo para tratar la aterosclerosis en sujetos con alto nivel de trigliceridos.
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物

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Also Published As

Publication number Publication date
AU2005286186A1 (en) 2006-03-30
BRPI0515906A (pt) 2008-08-12
TNSN07100A1 (fr) 2008-06-02
NO20071510L (no) 2007-06-11
TW200616963A (en) 2006-06-01
NL1030010C2 (nl) 2006-11-06
KR100857462B1 (ko) 2008-09-08
PA8646101A1 (es) 2006-06-02
NL1030010A1 (nl) 2006-03-27
EA200700479A1 (ru) 2007-10-26
WO2006033002A1 (en) 2006-03-30
MA28868B1 (fr) 2007-09-03
US20060063803A1 (en) 2006-03-23
GT200500265A (es) 2006-04-21
US20060247272A1 (en) 2006-11-02
EP1799648A1 (en) 2007-06-27
PE20060820A1 (es) 2006-09-06
IL181722A0 (en) 2007-07-04
CR9012A (es) 2007-04-24
ECSP077333A (es) 2007-04-26
AR053094A1 (es) 2007-04-25
MX2007003441A (es) 2007-05-23
KR20070045346A (ko) 2007-05-02
JP2008513537A (ja) 2008-05-01
CA2581462A1 (en) 2006-03-30

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