MX2007010243A - Compuestos de 1,1,1-trifluoro-3-[(bencil)-(pirimidin-2-il)-amino]- propan-2-ol sustituidos. - Google Patents

Compuestos de 1,1,1-trifluoro-3-[(bencil)-(pirimidin-2-il)-amino]- propan-2-ol sustituidos.

Info

Publication number
MX2007010243A
MX2007010243A MX2007010243A MX2007010243A MX2007010243A MX 2007010243 A MX2007010243 A MX 2007010243A MX 2007010243 A MX2007010243 A MX 2007010243A MX 2007010243 A MX2007010243 A MX 2007010243A MX 2007010243 A MX2007010243 A MX 2007010243A
Authority
MX
Mexico
Prior art keywords
compounds
cholesterol
pyrimidin
trifluoro
benzyl
Prior art date
Application number
MX2007010243A
Other languages
English (en)
Inventor
George Chang
Michael Patrick Pence
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MX2007010243A publication Critical patent/MX2007010243A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos de 1,1,1-trifluoro-3-[(bencil)-(pirimidin-2-il)-amino]- propan-2-ol sustituidos, composiciones farmaceuticas que contienen tales compuestos y uso de tales compuestos para elevar ciertos niveles de lipido en plasma, incluyendo colesterol - lipoproteina de alta densidad y para reducir otros niveles de lipido en plasma, tales como colesterol LDL y trigliceridos y de acuerdo con lo anterior tratar enfermedades que se vean afectadas por bajos niveles de colesterol HDL y/o altos niveles de colesterol LDL y trigliceridos, tales como aterosclerosis y enfermedades cardiovasculares en algunos mamiferos, incluyendo humanos.
MX2007010243A 2005-02-23 2006-02-13 Compuestos de 1,1,1-trifluoro-3-[(bencil)-(pirimidin-2-il)-amino]- propan-2-ol sustituidos. MX2007010243A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65574005P 2005-02-23 2005-02-23
PCT/IB2006/000374 WO2006090250A1 (en) 2005-02-23 2006-02-13 Substituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-prop an-2-ol compounds

Publications (1)

Publication Number Publication Date
MX2007010243A true MX2007010243A (es) 2007-09-07

Family

ID=36215578

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010243A MX2007010243A (es) 2005-02-23 2006-02-13 Compuestos de 1,1,1-trifluoro-3-[(bencil)-(pirimidin-2-il)-amino]- propan-2-ol sustituidos.

Country Status (13)

Country Link
US (1) US20100130784A1 (es)
EP (1) EP1856060A1 (es)
JP (1) JP2008545617A (es)
KR (1) KR20070096041A (es)
CN (1) CN101128438A (es)
AU (1) AU2006217630A1 (es)
BR (1) BRPI0607839A2 (es)
CA (1) CA2598869A1 (es)
IL (1) IL184677A0 (es)
MX (1) MX2007010243A (es)
RU (1) RU2007131537A (es)
WO (1) WO2006090250A1 (es)
ZA (1) ZA200705972B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7790770B2 (en) * 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
JP4834699B2 (ja) * 2007-07-30 2011-12-14 田辺三菱製薬株式会社 医薬組成物
US20120179035A1 (en) * 2011-01-07 2012-07-12 General Electric Company Medical device with motion sensing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE296796T1 (de) * 1998-09-25 2005-06-15 Monsanto Co (r)-chirale halogenierte 1-substituierte amino- (n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins

Also Published As

Publication number Publication date
BRPI0607839A2 (pt) 2009-06-13
CN101128438A (zh) 2008-02-20
AU2006217630A1 (en) 2006-08-31
KR20070096041A (ko) 2007-10-01
WO2006090250A1 (en) 2006-08-31
RU2007131537A (ru) 2009-03-27
US20100130784A1 (en) 2010-05-27
EP1856060A1 (en) 2007-11-21
CA2598869A1 (en) 2006-08-31
JP2008545617A (ja) 2008-12-18
IL184677A0 (en) 2007-12-03
ZA200705972B (en) 2009-02-25

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