MXPA06013886A - Suspension farmaceutica inyectable que comprende posaconazol. - Google Patents
Suspension farmaceutica inyectable que comprende posaconazol.Info
- Publication number
- MXPA06013886A MXPA06013886A MXPA06013886A MXPA06013886A MXPA06013886A MX PA06013886 A MXPA06013886 A MX PA06013886A MX PA06013886 A MXPA06013886 A MX PA06013886A MX PA06013886 A MXPA06013886 A MX PA06013886A MX PA06013886 A MXPA06013886 A MX PA06013886A
- Authority
- MX
- Mexico
- Prior art keywords
- posaconazole
- approximately
- formulation
- further characterized
- formulation according
- Prior art date
Links
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title claims abstract description 215
- 229960001589 posaconazole Drugs 0.000 title claims abstract description 214
- 239000007971 pharmaceutical suspension Substances 0.000 title description 2
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- 238000009472 formulation Methods 0.000 claims abstract description 205
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- 238000001802 infusion Methods 0.000 claims description 53
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- 230000001012 protector Effects 0.000 claims description 21
- 239000004615 ingredient Substances 0.000 claims description 18
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 18
- 230000036470 plasma concentration Effects 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 14
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 14
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- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 9
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
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Applications Claiming Priority (2)
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|---|---|---|---|
| US57512604P | 2004-05-28 | 2004-05-28 | |
| PCT/US2005/018945 WO2005117831A1 (en) | 2004-05-28 | 2005-05-27 | Injectable pharmaceutical suspension comprising posaconazole |
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| MXPA06013886A true MXPA06013886A (es) | 2007-01-26 |
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| MXPA06013886A MXPA06013886A (es) | 2004-05-28 | 2005-05-27 | Suspension farmaceutica inyectable que comprende posaconazol. |
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|---|---|---|---|---|
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| RS56044B1 (sr) * | 2006-05-12 | 2017-09-29 | Christian Noe | Primena kombinovanih preparata koji sadrže antimikotike |
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| EP2451805A1 (en) | 2009-07-09 | 2012-05-16 | Sandoz AG | A crystalline form of posaconazole |
| WO2011144656A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Preparation of posaconazole intermediates |
| WO2011144655A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Process for the preparation of chiral hydrazides |
| CA2798010C (en) | 2010-05-19 | 2018-09-25 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| RU2585760C2 (ru) | 2010-05-19 | 2016-06-10 | Сандоз Аг | Способ получения хиральных триазолонов |
| EP3391890B1 (en) * | 2010-06-29 | 2021-08-25 | Merck Sharp & Dohme Corp. | Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin |
| CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
| CN103284959B (zh) * | 2012-02-22 | 2015-06-03 | 重庆圣华曦药业股份有限公司 | 泊沙康唑冻干粉针剂及制备方法 |
| CN102755628B (zh) * | 2012-07-16 | 2013-10-23 | 中国科学院微生物研究所 | 一种抗真菌的药物组合物 |
| CN102805731B (zh) * | 2012-08-22 | 2014-04-30 | 北京莱瑞森医药科技有限公司 | 泊沙康唑干混悬剂及其制备方法 |
| CN105030668B (zh) * | 2015-06-26 | 2018-03-27 | 济川药业集团有限公司 | 泊沙康唑口服混悬剂及其制备方法 |
| CN106333925B (zh) * | 2015-07-10 | 2019-06-18 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑液体混悬剂及其制备方法 |
| CN105997872B (zh) * | 2016-07-08 | 2019-02-19 | 河南省立眼科医院 | 一种含有泊沙康唑的眼用纳米胶束抗真菌溶液 |
| CN110582264B (zh) * | 2017-03-26 | 2022-11-11 | V·R·斯塔福德 | 眼睑皮肤状况的处理方法 |
| CA3063115A1 (en) * | 2017-04-12 | 2018-10-18 | Vikash J. BHAGWANDIN | Compositions, packaged pharmaceuticals, and methods of using posaconazole for the sensitization of resistant tumors |
| CN110507609B (zh) * | 2018-05-21 | 2021-09-17 | 上海医药工业研究院 | 泊沙康唑口服混悬剂的制备方法 |
| CN111514146A (zh) * | 2020-04-28 | 2020-08-11 | 山西振东泰盛制药有限公司 | 含有泊沙康唑的药物组合物 |
| CN113933131B (zh) * | 2021-09-24 | 2024-01-26 | 合肥天一生物技术研究所有限责任公司 | 一种阴道微生物荧光染色液 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| EP2090165A3 (en) * | 2001-04-03 | 2012-03-28 | Schering Corporation | Antifungal composition with enhanced bioavailability |
-
2005
- 2005-05-27 PE PE2005000599A patent/PE20060291A1/es not_active Application Discontinuation
- 2005-05-27 CN CNA2005800248542A patent/CN1988887A/zh active Pending
- 2005-05-27 RU RU2006146555/15A patent/RU2006146555A/ru not_active Application Discontinuation
- 2005-05-27 AU AU2005249502A patent/AU2005249502A1/en not_active Abandoned
- 2005-05-27 TW TW094117524A patent/TWI290051B/zh not_active IP Right Cessation
- 2005-05-27 WO PCT/US2005/018945 patent/WO2005117831A1/en not_active Ceased
- 2005-05-27 CA CA002567803A patent/CA2567803A1/en not_active Abandoned
- 2005-05-27 AR ARP050102203A patent/AR049063A1/es not_active Application Discontinuation
- 2005-05-27 EP EP05755118A patent/EP1761247A1/en not_active Withdrawn
- 2005-05-27 MX MXPA06013886A patent/MXPA06013886A/es unknown
- 2005-05-27 KR KR1020067024996A patent/KR20070027564A/ko not_active Withdrawn
- 2005-05-27 JP JP2007515456A patent/JP2008501034A/ja not_active Withdrawn
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- 2006-11-27 ZA ZA200609890A patent/ZA200609890B/xx unknown
- 2006-12-22 NO NO20066005A patent/NO20066005L/no not_active Application Discontinuation
Also Published As
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| NO20066005L (no) | 2007-02-27 |
| EP1761247A1 (en) | 2007-03-14 |
| TWI290051B (en) | 2007-11-21 |
| RU2006146555A (ru) | 2008-07-20 |
| WO2005117831A1 (en) | 2005-12-15 |
| AR049063A1 (es) | 2006-06-21 |
| ZA200609890B (en) | 2008-09-25 |
| KR20070027564A (ko) | 2007-03-09 |
| PE20060291A1 (es) | 2006-04-14 |
| CN1988887A (zh) | 2007-06-27 |
| JP2008501034A (ja) | 2008-01-17 |
| TW200609001A (en) | 2006-03-16 |
| AU2005249502A1 (en) | 2005-12-15 |
| CA2567803A1 (en) | 2005-12-15 |
| IL179627A0 (en) | 2007-05-15 |
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