MXPA06012279A

MXPA06012279A - Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar.

Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar.

Info

Publication number: MXPA06012279A
Authority: MX; Mexico
Prior art keywords: carbon atoms; alkyl; substituted; amino; phenyl
Prior art date: 2004-04-23

Application number

MXPA06012279A

Other languages

English (en)

Spanish (es)

Inventor

Jerome B Zeldis

Original Assignee

Celgene Corp

Priority date

2004-04-23

Filing date

2005-04-21

Publication date

2007-01-31

2005-04-21 Application filed by Celgene Corp filed Critical Celgene Corp

2007-01-31 Publication of MXPA06012279A publication Critical patent/MXPA06012279A/es

Links

238000000034 method Methods 0.000 title claims abstract description 51
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238000011282 treatment Methods 0.000 title claims description 31
239000000203 mixture Substances 0.000 title description 39
101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
-1 hydrate) Chemical class 0.000 claims abstract description 232
101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims abstract description 94
101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims abstract description 94
239000013543 active substance Substances 0.000 claims abstract description 90
150000003839 salts Chemical class 0.000 claims abstract description 40
239000012453 solvate Substances 0.000 claims abstract description 36
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 35
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210000004072 lung Anatomy 0.000 claims abstract description 10
238000001356 surgical procedure Methods 0.000 claims abstract description 7
125000004432 carbon atom Chemical group C* 0.000 claims description 291
125000000217 alkyl group Chemical group 0.000 claims description 264
125000004093 cyano group Chemical group *C#N 0.000 claims description 88
125000003545 alkoxy group Chemical group 0.000 claims description 84
229910052739 hydrogen Inorganic materials 0.000 claims description 81
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 79
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 77
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BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims description 20
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PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims description 15
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125000001624 naphthyl group Chemical group 0.000 claims description 11
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125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims description 10
125000004442 acylamino group Chemical group 0.000 claims description 10
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125000000000 cycloalkoxy group Chemical group 0.000 claims description 10
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 10
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HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims description 6
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150000002632 lipids Chemical class 0.000 claims description 6
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 6
229960001597 nifedipine Drugs 0.000 claims description 6
239000002571 phosphodiesterase inhibitor Substances 0.000 claims description 6
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 6
150000003815 prostacyclins Chemical class 0.000 claims description 6
229960003310 sildenafil Drugs 0.000 claims description 6
229930002534 steroid glycoside Natural products 0.000 claims description 6
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 claims description 6
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 5
239000003638 chemical reducing agent Substances 0.000 claims description 5
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 5
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KYBGGKMHMYDTDS-UHFFFAOYSA-N 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-(5-methyl-1,3,4-oxadiazol-2-yl)isoindole-1,3-dione Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(C=4OC(C)=NN=4)C=CC=C3C2=O)=O)=C1 KYBGGKMHMYDTDS-UHFFFAOYSA-N 0.000 claims description 2
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YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims description 2
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