MXPA06011270A - Composiciones fijadoras de iones. - Google Patents
Composiciones fijadoras de iones.Info
- Publication number
- MXPA06011270A MXPA06011270A MXPA06011270A MXPA06011270A MXPA06011270A MX PA06011270 A MXPA06011270 A MX PA06011270A MX PA06011270 A MXPA06011270 A MX PA06011270A MX PA06011270 A MXPA06011270 A MX PA06011270A MX PA06011270 A MXPA06011270 A MX PA06011270A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- core
- component
- shell
- solute
- Prior art date
Links
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Applications Claiming Priority (5)
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Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| MXPA06002257A (es) | 2003-08-26 | 2006-05-17 | Shire Holdings Ag | Farmaceutica que comprende compuestos de lantano. |
| BRPI0509331B8 (pt) * | 2004-03-30 | 2021-05-25 | Ilypsa Inc | uso de uma composição de ligação de sódio |
| PT2184059E (pt) * | 2004-03-30 | 2012-07-06 | Relypsa Inc | Polímeros de ligação a ião e seus usos |
| GB2446077B (en) | 2005-09-30 | 2010-10-13 | Ilypsa Inc | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| WO2007038801A2 (en) * | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof |
| CA2624112A1 (en) * | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
| CN100398112C (zh) * | 2006-03-24 | 2008-07-02 | 辽宁诺康生物制药有限责任公司 | 一种治疗血磷酸盐过多症的药物及其制备方法 |
| CN102940878A (zh) * | 2006-10-06 | 2013-02-27 | Scil技术股份有限公司 | 脊柱髓核植入物 |
| EP2107072A1 (en) * | 2006-12-26 | 2009-10-07 | Otsuka Pharmaceutical Factory, Inc. | Sodium absorption inhibitor, potassium absorption inhibitor, phosphorus absorption inhibitor and preventive agent, therapeutic agent and food containing the same |
| EP2108661A1 (en) | 2006-12-26 | 2009-10-14 | Chisso Corporation | Metal salt of crosslinked cellulose derivative |
| RU2009144972A (ru) * | 2007-05-04 | 2011-06-10 | Айронвуд Фармасьютикалз, Инк. (Us) | Композиции и способы лечения нарушений, ассоциированных с задержкой соли или жидкости |
| CN101835500B (zh) * | 2007-08-29 | 2014-05-28 | 吸附剂治疗学公司 | 具有可变抗衡离子含量的吸收性聚合物组合物及其制备方法和用途 |
| JP5294681B2 (ja) * | 2008-04-28 | 2013-09-18 | 東京エレクトロン株式会社 | 基板処理装置及びその基板搬送方法 |
| AU2013204879B2 (en) * | 2008-08-22 | 2015-10-29 | Vifor (International) Ltd. | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
| US8337824B2 (en) * | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| US20100111892A1 (en) * | 2008-08-22 | 2010-05-06 | Relypsa, Inc. | Crosslinked polyfluoroacrylic acid and processes for the preparation thereof |
| MX389664B (es) | 2008-08-22 | 2025-03-20 | Vifor Int Ltd | Polimeros reticulados de intercambio cationico, composiciones y su uso en el tratamiento de la hipercalcemia |
| US20100104527A1 (en) * | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| WO2010132662A1 (en) * | 2009-05-13 | 2010-11-18 | Relypsa, Inc. | Powder formulations of potassium-binding active agents |
| ES2670580T3 (es) | 2010-03-20 | 2018-05-31 | Relypsa, Inc. | Procedimiento continuo para preparar partículas de polifluoroacrilato |
| US9314523B2 (en) | 2010-09-21 | 2016-04-19 | Elwha Llc | Ingestible salt grabber |
| KR101896732B1 (ko) | 2011-02-11 | 2018-09-07 | 제트에스 파마, 인코포레이티드 | 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄 |
| US9453092B2 (en) | 2011-06-27 | 2016-09-27 | Relypsa, Inc. | Process for converting a polymeric ester to a polymeric acid |
| WO2013003495A2 (en) | 2011-06-27 | 2013-01-03 | Relypsa, Inc. | Fluorination of acrylate esters and derivatives |
| US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
| HK1215861A1 (zh) * | 2012-07-11 | 2016-09-23 | Zs Pharma, Inc | 用於治疗高钙血症患者高钾血症的微孔硅酸锆以及用於治疗高钾血症的改进的含钙组合物 |
| HK1203420A1 (en) * | 2012-07-19 | 2015-10-30 | Vifor (International) Ltd. | Compositions comprising crosslinked cation-binding polymers |
| JP6115973B2 (ja) | 2012-08-09 | 2017-04-19 | パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー | ポリマー材料の乾燥方法 |
| JP6475624B2 (ja) * | 2012-10-08 | 2019-02-27 | レリプサ， インコーポレイテッド | 高血圧症及び高カリウム血症を治療するためのカリウム結合剤 |
| KR102184602B1 (ko) | 2012-10-22 | 2020-11-30 | 제트에스 파마, 인코포레이티드 | 고칼륨혈증의 치료를 위한 미세다공성 지르코늄 실리케이트 |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| SI3287133T1 (sl) | 2013-06-05 | 2019-09-30 | Tricida Inc. | Polimeri, ki vežejo protone,za peroralno dajanje |
| US10393749B2 (en) * | 2013-12-11 | 2019-08-27 | Shiseido Company, Ltd. | Marker for early diagnosis of kidney failure |
| US9675636B2 (en) * | 2014-01-31 | 2017-06-13 | University Of Kansas | Micelle sequestering polymers |
| JP6468780B2 (ja) * | 2014-09-30 | 2019-02-13 | 積水化成品工業株式会社 | 中空樹脂粒子及びその製造方法 |
| LT3229816T (lt) | 2014-12-10 | 2020-05-25 | Tricida Inc. | Protoną prijungiantys polimerai, skirti peroraliniam įvedimui |
| TW201628631A (zh) * | 2014-12-23 | 2016-08-16 | 亞德利克斯公司 | 用於治療高血鉀症之組合物及方法 |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
| ITUB20159278A1 (it) | 2015-12-23 | 2017-06-23 | Rjw Pharma Llc | Procedimento per la sintesi di patiromer |
| WO2017193024A1 (en) | 2016-05-06 | 2017-11-09 | Tricida, Inc. | Hcl-binding compositions for and method of treating acid-base disorders |
| JP2018125951A (ja) * | 2017-01-31 | 2018-08-09 | 日本電産株式会社 | モータ及びそれを備えた送風装置 |
| IL319146A (en) | 2017-11-03 | 2025-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| JP7365631B2 (ja) * | 2019-09-02 | 2023-10-20 | 国立大学法人福井大学 | ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法 |
| CN113244339B (zh) * | 2021-06-04 | 2021-09-24 | 南京厚生药业有限公司 | 一种用于高脂血症的考来烯胺散及其制备方法 |
| US20240139234A1 (en) * | 2021-11-17 | 2024-05-02 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Pharmaceutical polymer for treating hyperkalemia and preparation method thereof |
| WO2024035944A1 (en) * | 2022-08-12 | 2024-02-15 | University Of Kansas | Extraction of critical minerals using polyanions |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2340111A (en) * | 1942-07-03 | 1944-01-25 | Gen Electric | Process for removing cations from liquid media |
| US2611730A (en) | 1950-09-02 | 1952-09-23 | Simth Kline & French Lab | Medical preparation for reducing the body level of sodium |
| US2798053A (en) * | 1952-09-03 | 1957-07-02 | Goodrich Co B F | Carboxylic polymers |
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| US3499960A (en) | 1965-01-25 | 1970-03-10 | Merck & Co Inc | Palatable coated particles of an anion exchange resin |
| FR2171934B1 (https=) * | 1972-02-16 | 1974-09-13 | Rhone Poulenc Sa | |
| US3974272A (en) | 1972-09-01 | 1976-08-10 | Merck & Co., Inc. | Palatable cholestyramine coacervate compositions |
| US4143130A (en) | 1977-08-29 | 1979-03-06 | Warren-Teed Laboratories, Inc. | Method for treating kidney stones |
| US4470975A (en) | 1977-10-21 | 1984-09-11 | The Johns Hopkins University | Method and composition for the elimination of water from an animal body |
| US4191812A (en) * | 1978-09-19 | 1980-03-04 | Rohm And Haas Company | Ion exchange process involving emulsion ion exchange resins |
| US4380590A (en) | 1978-09-19 | 1983-04-19 | Rohm And Haas Company | Emulsion copolymer cation exchange resins |
| SE8003805L (sv) | 1980-05-21 | 1981-11-22 | Haessle Ab | En farmaceutisk beredning med forbettrade utlosningsegenskap |
| US4362711A (en) | 1980-07-11 | 1982-12-07 | Evreka Inc. | Blood cholesterol level reducing agent and method |
| DE3031737A1 (de) | 1980-08-22 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von perlpolymerisaten einheitlicher teilchengroesse |
| DE3149136A1 (de) * | 1981-12-11 | 1983-06-23 | Robert Bosch Gmbh, 7000 Stuttgart | Einrichtung zur regelung des kraftstoff-luftverhaeltnisses bei brennkraftmaschinen |
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| US5238924A (en) * | 1984-05-03 | 1993-08-24 | Merck & Co., Inc. | Treatment of renal diseases with ace inhibitors |
| US4675140A (en) | 1984-05-18 | 1987-06-23 | Washington University Technology Associates | Method for coating particles or liquid droplets |
| US4747881A (en) | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US5186937A (en) | 1985-06-07 | 1993-02-16 | A.E.C. Societe De Chimie Organique Et Biologique | Composition for feeding ruminants |
| IT1190349B (it) | 1986-06-16 | 1988-02-16 | Prodotti Formenti Srl | Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle |
| JPS63218713A (ja) * | 1987-02-17 | 1988-09-12 | Daikin Ind Ltd | α−フルオロアクリル酸系重合体ならびに用途 |
| US4837015A (en) * | 1987-03-05 | 1989-06-06 | Carolina Medical Products Company, Inc. | Alkali metal ion-charged, cation exchanger and use thereof to adjust sodium, potassium and calcium body fluid levels |
| US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| FR2634377B1 (fr) * | 1988-06-30 | 1991-09-27 | Cortial | Nouvelle forme pharmaceutique a liberation prolongee a base d'un complexe resine-principe actif |
| GB8817015D0 (en) | 1988-07-16 | 1988-08-17 | Reckitt & Colmann Prod Ltd | Method of treatment |
| GB8829088D0 (en) | 1988-12-13 | 1989-01-25 | Smith Kline French Lab | Compounds |
| US5236701A (en) | 1989-07-19 | 1993-08-17 | Lowchol Scientific Inc. | Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol |
| DE3928990A1 (de) | 1989-09-01 | 1991-03-07 | Bayer Ag | Verfahren zur herstellung von (alpha)-fluoroacrylsaeurederivaten |
| US5112993A (en) | 1989-11-14 | 1992-05-12 | E. I. Du Pont De Nemours And Company | Process for the preparation of difluoromaleic anhydride |
| US5091175A (en) | 1990-05-14 | 1992-02-25 | Erbamont Inc. | Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane |
| ES2070307T3 (es) * | 1990-07-04 | 1995-06-01 | Marcin Krotkiewski | Una preparacion para el tratamiento de la hipertension. |
| IE914179A1 (en) | 1990-12-07 | 1992-06-17 | Ici Plc | Nitrogen derivatives |
| US5162110A (en) * | 1990-12-19 | 1992-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Binding theophylline to ion exchange resins |
| US5281631A (en) | 1991-12-20 | 1994-01-25 | Arch Development Corp. | Phosphonic acid based ion exchange resins |
| ATE130193T1 (de) * | 1992-03-28 | 1995-12-15 | Hoechst Ag | Arzneimittel aus polyhydroxymethylenderivaten, verfahren zu deren herstellung und verwendung. |
| JPH08500386A (ja) | 1992-08-20 | 1996-01-16 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 架橋ポリマーアンモニウム塩 |
| WO1994027619A1 (en) | 1993-05-20 | 1994-12-08 | Geltex Pharmaceuticals, Inc. | Process for adjusting ion concentration in a patient and compositions therefor |
| US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| JPH09506342A (ja) * | 1993-11-25 | 1997-06-24 | サルテルナテ・ベー・ブイ | 一価カチオンに結合する粒子、並びにナトリウムおよび／またはカリウムイオンを捕捉して除去するための上記粒子の使用および方法 |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| US5824339A (en) | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| JP3885130B2 (ja) | 1996-06-11 | 2007-02-21 | 株式会社大塚製薬工場 | グアニジノ化合物低下剤並びに水分及びカリウムイオン吸着剤 |
| WO1997049384A1 (en) | 1996-06-26 | 1997-12-31 | Board Of Regents, The University Of Texas System | Hot-melt extrudable pharmaceutical formulation |
| WO1997049387A1 (en) * | 1996-06-27 | 1997-12-31 | G.D. Searle And Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| US6623759B2 (en) * | 1996-06-28 | 2003-09-23 | Astrazeneca Ab | Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof |
| US5935599A (en) | 1996-10-28 | 1999-08-10 | The Board Of Trustees Of The University Of Illinois | Polymer-associated liposomes for drug delivery and method of manufacturing the same |
| JPH10130154A (ja) | 1996-10-29 | 1998-05-19 | Otsuka Pharmaceut Factory Inc | 腎疾患患者用延命率改善薬 |
| CA2315088A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Process for manufacturing bite-dispersion tablets |
| KR100440544B1 (ko) * | 1998-07-31 | 2004-07-15 | 니켄 가가쿠 가부시키가이샤 | 양이온 교환수지 제제 |
| US6294163B1 (en) | 1998-10-02 | 2001-09-25 | Geltex Pharmaceuticals, Inc. | Polymers containing guanidinium groups as bile acid sequestrants |
| IL142911A0 (en) * | 1998-11-06 | 2002-04-21 | Searle & Co | Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease |
| AU1998200A (en) * | 1999-01-07 | 2000-07-24 | Elan Corporation, Plc | Multiparticulate oral dosage forms |
| US6558665B1 (en) | 1999-05-18 | 2003-05-06 | Arch Development Corporation | Encapsulating particles with coatings that conform to size and shape of the particles |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| EP1249240A4 (en) | 2000-01-14 | 2003-03-19 | Otsuka Pharma Co Ltd | INHIBITORS OF SODIUM ION ABSORPTION, AND PROPHYLACTIC OR THERAPEUTIC AGENTS AND FOOD PRODUCTS CONTAINING SAID INHIBITORS |
| FR2812632B1 (fr) | 2000-08-07 | 2003-03-07 | Solvay | Procede pour la synthese de composes fluoroorganiques |
| AU2002232955A1 (en) | 2000-11-20 | 2002-05-27 | Dow Global Technologies Inc. | In vivo use of water absorbent polymers |
| WO2002062356A2 (en) | 2001-02-06 | 2002-08-15 | Ash Medical Systems, Inc. | Monovalent-selective cation exchangers as oral sorbent therapy |
| US7033639B2 (en) | 2001-05-16 | 2006-04-25 | Rohm And Haas Company | Polyaniline coating composition |
| US6881484B2 (en) | 2001-05-30 | 2005-04-19 | Mitsubishi Kagaku Iatron, Inc. | Core-shell particle including signal-generating substance enclosed therein and process for producing the same |
| JP2004149525A (ja) | 2002-10-09 | 2004-05-27 | Sekisui Chem Co Ltd | カリウムイオン吸着剤及びその製造方法、並びに高カリウム血症治療剤 |
| JP5826445B2 (ja) * | 2003-02-25 | 2015-12-02 | フィンフィーズ フィンランド オイ | 擬似移動床システム及び方法 |
| WO2005065291A2 (en) | 2003-12-31 | 2005-07-21 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
| US7556799B2 (en) * | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
| US7429394B2 (en) * | 2004-03-30 | 2008-09-30 | Relypsa, Inc. | Ion binding compositions |
| BRPI0509331B8 (pt) | 2004-03-30 | 2021-05-25 | Ilypsa Inc | uso de uma composição de ligação de sódio |
| US7854924B2 (en) * | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| US8282960B2 (en) * | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
| US8192758B2 (en) * | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
| GB2446077B (en) | 2005-09-30 | 2010-10-13 | Ilypsa Inc | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| CA2624112A1 (en) | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
| US8337824B2 (en) | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| US20100111892A1 (en) | 2008-08-22 | 2010-05-06 | Relypsa, Inc. | Crosslinked polyfluoroacrylic acid and processes for the preparation thereof |
| US20100104527A1 (en) | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
-
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- 2005-03-30 DE DE112005000730.8T patent/DE112005000730B4/de not_active Expired - Lifetime
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- 2005-03-30 EP EP05747062A patent/EP1732524B1/en not_active Expired - Lifetime
- 2005-03-30 US US11/095,760 patent/US7776319B2/en not_active Expired - Fee Related
- 2005-03-30 EP EP05731099A patent/EP1732516B1/en not_active Expired - Lifetime
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- 2005-03-30 WO PCT/US2005/010747 patent/WO2005097072A1/en not_active Ceased
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2008
- 2008-03-26 US US12/055,726 patent/US8216560B2/en active Active
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2010
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2011
- 2011-01-27 US US13/015,134 patent/US8475780B2/en not_active Expired - Fee Related
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2012
- 2012-10-05 US US13/646,104 patent/US20130272990A1/en not_active Abandoned
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2014
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2015
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2016
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2019
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