MXPA05013752A - Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos. - Google Patents

Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos.

Info

Publication number
MXPA05013752A
MXPA05013752A MXPA05013752A MXPA05013752A MXPA05013752A MX PA05013752 A MXPA05013752 A MX PA05013752A MX PA05013752 A MXPA05013752 A MX PA05013752A MX PA05013752 A MXPA05013752 A MX PA05013752A MX PA05013752 A MXPA05013752 A MX PA05013752A
Authority
MX
Mexico
Prior art keywords
azabicyclo
carboxylates
intermediates
hexane
dimethyl
Prior art date
Application number
MXPA05013752A
Other languages
English (en)
Spanish (es)
Inventor
Eugene J Vater
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MXPA05013752A publication Critical patent/MXPA05013752A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MXPA05013752A 2003-06-17 2004-06-15 Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos. MXPA05013752A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951603P 2003-06-17 2003-06-17
PCT/US2004/019135 WO2004113295A1 (en) 2003-06-17 2004-06-15 Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

Publications (1)

Publication Number Publication Date
MXPA05013752A true MXPA05013752A (es) 2006-03-08

Family

ID=33539184

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013752A MXPA05013752A (es) 2003-06-17 2004-06-15 Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos.

Country Status (12)

Country Link
US (3) US7309717B2 (enExample)
EP (1) EP1633711B1 (enExample)
JP (1) JP4825129B2 (enExample)
CN (2) CN101823965B (enExample)
AT (1) ATE489365T1 (enExample)
CA (1) CA2526635C (enExample)
DE (1) DE602004030239D1 (enExample)
ES (1) ES2354817T3 (enExample)
MX (1) MXPA05013752A (enExample)
SG (1) SG180022A1 (enExample)
WO (1) WO2004113295A1 (enExample)
ZA (1) ZA201006378B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
US20060276407A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
EP1898941A2 (en) * 2005-06-02 2008-03-19 Schering Corporation Controlled-release formulation useful for treating disorders associated with hepatitis c virus
US20060281689A1 (en) * 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
US8119602B2 (en) 2005-06-02 2012-02-21 Schering Corporation Administration of HCV protease inhibitors in combination with food to improve bioavailability
ES2572980T3 (es) * 2005-06-02 2016-06-03 Merck Sharp & Dohme Corp. Combinación de inhibidores de la proteasa del VHC con un tensioactivo
WO2006130666A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
WO2006130687A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis c virus protease inhibitor
WO2006130552A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
WO2007075790A1 (en) * 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof
WO2007074391A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar Preparation of a key intermediate in the synthesis of rosuvastatin
KR101059593B1 (ko) 2006-04-11 2011-08-25 노파르티스 아게 Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도
WO2007122744A1 (ja) 2006-04-17 2007-11-01 Sumitomo Chemical Company, Limited 多環式プロリン誘導体又はその酸付加塩の製造方法
CN101415676A (zh) 2006-04-17 2009-04-22 住友化学株式会社 N-叔丁氧基羰基-2-吡咯烷酮类及其制造方法
JP5272324B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法
JP5272325B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 多環式プロリン誘導体またはその酸付加塩の製造方法
SG160363A1 (en) 2006-04-17 2010-04-29 Sumitomo Chemical Company Limt Ester of cyclic carboxylic acid
JP2010513492A (ja) * 2006-12-19 2010-04-30 シェーリング コーポレイション ３−（アミノ）−３−（シクロブチルメチル）−２−（ヒドロキシ）−プロピオンアミド塩酸塩の調製
JP5095824B2 (ja) 2007-10-10 2012-12-12 ノバルティス アーゲー スピロピロリジン類およびｈｃｖおよびｈｉｖ感染に対するその使用
WO2009073380A1 (en) * 2007-11-28 2009-06-11 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
US20110137046A1 (en) * 2008-06-05 2011-06-09 Fen-Er Chen Preparation method of (4s,5r)-semiester
CN102816106A (zh) 2008-06-24 2012-12-12 默沙东公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
JP5613168B2 (ja) * 2008-11-17 2014-10-22 アナディス ファーマシューティカルズ インク デオキシリボフラノース化合物の製造方法
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
CN101863866B (zh) * 2009-04-16 2012-07-04 上海联友制药技术有限公司 3,3-二甲基环丙烷-1,2-二甲酸酐的合成方法
WO2011014494A1 (en) 2009-07-29 2011-02-03 Schering Corporation ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF β-AMINO-α- HYDROXY AMIDES
CN102070575B (zh) * 2010-12-28 2012-10-17 上海北卡医药技术有限公司 卡隆酸酐的合成方法
CN102127040B (zh) * 2010-12-30 2013-05-01 西安彩晶光电科技股份有限公司 6,6-二甲基-3-氧杂双环[3.1.0]己烷-2,4-二酮的制备方法
FR2972453B1 (fr) * 2011-03-09 2013-11-29 Minakem Nouveau procede de synthese du (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate de methyle ou de l'un de ses sels
JP2013010738A (ja) * 2011-05-31 2013-01-17 Sumitomo Chemical Co Ltd エステル化合物の製造方法
JP2013010732A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd プロリン化合物の製造方法
JP2013010733A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd ヘミアミナール化合物の製造方法及びシアノアミン化合物の製造方法
JP2013010734A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd Ｎ−置換ラクタム化合物の製造方法
WO2013178682A2 (en) 2012-05-30 2013-12-05 Chemo Ibérica, S.A. Multicomponent process for the preparation of bicyclic compounds
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN104151279A (zh) * 2014-08-26 2014-11-19 广西梧松林化集团有限公司 卡龙酸酐的合成方法
CN114539125B (zh) * 2022-03-07 2024-02-09 杭州国瑞生物科技有限公司 一种帕西洛韦中间体的合成方法
CN114478690B (zh) * 2022-03-08 2024-01-02 新发药业有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷衍生物的制备方法
WO2023175526A1 (en) * 2022-03-16 2023-09-21 Laurus Labs Limited Process for preparation of azabicyclo [3.1.0] hexane intermediates
CN114605309B (zh) * 2022-03-23 2023-07-21 浙江新和成股份有限公司 一种氮杂双环衍生物的合成方法
CN114989067B (zh) * 2022-07-18 2022-10-28 苏州奥普拓新材料有限公司 一种帕罗韦德中间体的合成方法
CN115947679B (zh) * 2022-12-16 2024-06-07 杭州澳赛诺生物科技有限公司 一种6,6-二甲基-3-杂氮-双环[3.1.0]己烷-2-羧酸甲酯的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2376120A1 (fr) * 1976-12-30 1978-07-28 Roussel Uclaf Procede de preparation d'esters d'alcoyle inferieur d'acides cis ou trans 3-formyl cyclopropane 1-carboxyliques 2,2-disubstitues racemiques
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
CA1117128A (en) * 1978-10-27 1982-01-26 Derek A. Wood 2-cyano-3-azabicyclo(3.1.0)hexane
SI1385870T1 (sl) 2000-07-21 2010-08-31 Schering Corp Peptidi kot NS3-serin proteazni inhibitorji virusa hepatitisa C
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
IL144815A (en) * 2000-08-11 2005-07-25 Sumitomo Chemical Co Process for producing carbonyl or hydroxy compound

Also Published As

Publication number Publication date
US7728165B2 (en) 2010-06-01
US20050059648A1 (en) 2005-03-17
CN1805931A (zh) 2006-07-19
CN101823965B (zh) 2012-12-19
EP1633711A1 (en) 2006-03-15
EP1633711B1 (en) 2010-11-24
HK1081199A1 (en) 2006-05-12
JP4825129B2 (ja) 2011-11-30
CA2526635C (en) 2012-06-05
WO2004113295A1 (en) 2004-12-29
ES2354817T3 (es) 2011-03-18
CN1805931B (zh) 2010-06-23
US7309717B2 (en) 2007-12-18
CA2526635A1 (en) 2004-12-29
US20080114179A1 (en) 2008-05-15
SG180022A1 (en) 2012-05-30
US20090247784A1 (en) 2009-10-01
DE602004030239D1 (de) 2011-01-05
CN101823965A (zh) 2010-09-08
JP2007520434A (ja) 2007-07-26
ATE489365T1 (de) 2010-12-15
US7569705B2 (en) 2009-08-04
ZA201006378B (en) 2011-05-25

Similar Documents

Publication Publication Date Title
MXPA05013752A (es) Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos.
BR0316375A (pt) Diazinopirimidinas
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
PL392725A1 (pl) Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
MY147211A (en) Novel dihydropseudoerythromycin derivatives
MXPA05013751A (es) Procedimiento e intermediarios para la preparacion de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida o sus sales.
UA84271C2 (en) Formate salt of o-desmethyl-venlafaxine
MXPA02011458A (es) Derivados de acilfenilurea, metodos para su produccion y uso de los mismos como farmacos.
YU69902A (sh) Novi derivati piperazina
AU2364600A (en) Heteroroaromatic amides as inhibitor of factor xa
IL164509A0 (en) Furyl compounds
JO2493B1 (en) New phenyl azatidinone with improved physical properties and methods of preparation of drugs containing it and its uses
TW200500339A (en) Pyrrolidine derivatives, and process for the preparation
IL164613A0 (en) Thienyl compounds
DE602004024213D1 (en) Aminopropanolderivate
IL168718A (en) Biguanide derivatives, compositions comprising the derivatives, process for preparing an antimicrobial compound and use of the derivatives in the preparation of medicaments
MY142474A (en) 1h-quinazoline-2,4-diones
GB0229081D0 (en) Multifunctional cationic photoinitiators, their preparation and use
MY139228A (en) Imidazolinylmethyl aralkylsulfonamides
GB0212410D0 (en) Organic compounds
TW200612959A (en) Method for preparing hydroxamic acids
MXPA04005788A (es) Proceso para preparacion de derivados de [1,4,5]-oxadiazepina.
ATE446952T1 (de) Herstellungsverfahren von 2-cyanopyridinen
HRP20020864A2 (en) Cyclipostins, a method for their production and the use of the same
MY136638A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status