CN101823965B - 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体 - Google Patents

制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体 Download PDF

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Publication number
CN101823965B
CN101823965B CN2010101632513A CN201010163251A CN101823965B CN 101823965 B CN101823965 B CN 101823965B CN 2010101632513 A CN2010101632513 A CN 2010101632513A CN 201010163251 A CN201010163251 A CN 201010163251A CN 101823965 B CN101823965 B CN 101823965B
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compound
added
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alkyl
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Chinese (zh)
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CN101823965A (zh
Inventor
J·帕
A·苏哈卡
G·S·王
M·陈
J·韦伯
X·杨
D·郭
I·永
R·R·拉哈文
M·塔马雷斯
W·童
E·J·瓦特
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2010101632513A 2003-06-17 2004-06-15 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体 Expired - Fee Related CN101823965B (zh)

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US47951603P 2003-06-17 2003-06-17
US60/479516 2003-06-17

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CN2004800166393A Division CN1805931B (zh) 2003-06-17 2004-06-15 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体

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CN101823965A CN101823965A (zh) 2010-09-08
CN101823965B true CN101823965B (zh) 2012-12-19

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CN2004800166393A Expired - Fee Related CN1805931B (zh) 2003-06-17 2004-06-15 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体

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US (3) US7309717B2 (enExample)
EP (1) EP1633711B1 (enExample)
JP (1) JP4825129B2 (enExample)
CN (2) CN101823965B (enExample)
AT (1) ATE489365T1 (enExample)
CA (1) CA2526635C (enExample)
DE (1) DE602004030239D1 (enExample)
ES (1) ES2354817T3 (enExample)
MX (1) MXPA05013752A (enExample)
SG (1) SG180022A1 (enExample)
WO (1) WO2004113295A1 (enExample)
ZA (1) ZA201006378B (enExample)

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JP5272324B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法
JP5272325B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 多環式プロリン誘導体またはその酸付加塩の製造方法
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JP2010513492A (ja) * 2006-12-19 2010-04-30 シェーリング コーポレイション ３−（アミノ）−３−（シクロブチルメチル）−２−（ヒドロキシ）−プロピオンアミド塩酸塩の調製
JP5095824B2 (ja) 2007-10-10 2012-12-12 ノバルティス アーゲー スピロピロリジン類およびｈｃｖおよびｈｉｖ感染に対するその使用
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US20110137046A1 (en) * 2008-06-05 2011-06-09 Fen-Er Chen Preparation method of (4s,5r)-semiester
CN102816106A (zh) 2008-06-24 2012-12-12 默沙东公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
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Also Published As

Publication number Publication date
US7728165B2 (en) 2010-06-01
US20050059648A1 (en) 2005-03-17
CN1805931A (zh) 2006-07-19
MXPA05013752A (es) 2006-03-08
EP1633711A1 (en) 2006-03-15
EP1633711B1 (en) 2010-11-24
HK1081199A1 (en) 2006-05-12
JP4825129B2 (ja) 2011-11-30
CA2526635C (en) 2012-06-05
WO2004113295A1 (en) 2004-12-29
ES2354817T3 (es) 2011-03-18
CN1805931B (zh) 2010-06-23
US7309717B2 (en) 2007-12-18
CA2526635A1 (en) 2004-12-29
US20080114179A1 (en) 2008-05-15
SG180022A1 (en) 2012-05-30
US20090247784A1 (en) 2009-10-01
DE602004030239D1 (de) 2011-01-05
CN101823965A (zh) 2010-09-08
JP2007520434A (ja) 2007-07-26
ATE489365T1 (de) 2010-12-15
US7569705B2 (en) 2009-08-04
ZA201006378B (en) 2011-05-25

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