MXPA05012072A - Complejos de quelatos de metal inmovilizados sobre soportes solidos para la preparacion de peptidos. - Google Patents
Complejos de quelatos de metal inmovilizados sobre soportes solidos para la preparacion de peptidos.Info
- Publication number
- MXPA05012072A MXPA05012072A MXPA05012072A MXPA05012072A MXPA05012072A MX PA05012072 A MXPA05012072 A MX PA05012072A MX PA05012072 A MXPA05012072 A MX PA05012072A MX PA05012072 A MXPA05012072 A MX PA05012072A MX PA05012072 A MXPA05012072 A MX PA05012072A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- solid phase
- anchoring part
- peptides
- metal chelate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invencion describe el uso de una fase solida activada y una parte de sujecion, la cual es adherida a un peptido para la sintesis de peptidos en fase solida, en donde la parte de sujecion es adherida de manera coordinada y reversible a la fase solida activada. Ademas se proporciona un proceso para la separacion competitiva de la parte de sujecion, para la purificacion y replegamiento de los peptidos. Se proporcionan peptidos con una parte de sujecion para la adherencia coordinada y reversible de los peptidos a una fase solida activada. En las modalidades preferidas, la union entren el(los) peptido(s) y la fase solida consiste de un complejo de quelatos de metal. El peptido inmovilizado se sujeta a los pasos sinteticos para el alargamiento de la secuencia (es decir, es un peptido creciente). El ion de metal preferido para los complejos de quelatos es Cu(2+) y el ligando preferido en la resina es 1,10-fenantrolina.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47272403P | 2003-05-23 | 2003-05-23 | |
EP03017839 | 2003-08-05 | ||
EP04006195 | 2004-03-16 | ||
PCT/EP2004/005568 WO2004104023A2 (en) | 2003-05-23 | 2004-05-24 | Metal chelate complexes immobilized on solid supports for peptide preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05012072A true MXPA05012072A (es) | 2006-02-22 |
Family
ID=37695241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05012072A MXPA05012072A (es) | 2003-05-23 | 2004-05-24 | Complejos de quelatos de metal inmovilizados sobre soportes solidos para la preparacion de peptidos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20070027303A1 (es) |
EP (2) | EP1626982B1 (es) |
JP (1) | JP2007528870A (es) |
CN (1) | CN1795202B (es) |
AT (1) | ATE361311T1 (es) |
AU (1) | AU2004240766A1 (es) |
CA (1) | CA2524693A1 (es) |
DE (1) | DE602004006254T2 (es) |
DK (1) | DK1626982T3 (es) |
EA (1) | EA008305B1 (es) |
ES (1) | ES2287728T3 (es) |
MX (1) | MXPA05012072A (es) |
PL (1) | PL1626982T3 (es) |
SI (1) | SI1626982T1 (es) |
WO (1) | WO2004104023A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
WO2006056443A2 (en) * | 2004-11-24 | 2006-06-01 | Aplagen Gmbh | Method for solid-phase peptide synthesis and purification |
WO2007130275A2 (en) * | 2006-05-03 | 2007-11-15 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
GB0610479D0 (en) * | 2006-05-26 | 2006-07-05 | Ge Healthcare Bio Sciences Ab | A method for generating metal chelating affinity ligands |
US8999157B2 (en) | 2007-07-09 | 2015-04-07 | Ge Healthcare Bio-Sciences Ab | Method for preparation of a biomolecule adsorbent |
CN101808731B (zh) | 2007-08-06 | 2013-10-23 | 马普科技促进协会 | 用于固定金属离子色谱法(imac)的螯合基团的固定 |
CN103965285B (zh) * | 2013-02-06 | 2016-12-28 | 北京大学 | 一种以超顺磁纳米颗粒为固相进行多肽合成及同步构建多肽磁纳米探针的方法 |
CN103652892B (zh) * | 2013-12-03 | 2015-07-08 | 江西益佰年药业股份有限公司 | 乌鸡肽铁螯合物粉制备方法 |
US10098959B2 (en) | 2014-05-01 | 2018-10-16 | Ionis Pharmaceuticals, Inc. | Method for synthesis of reactive conjugate clusters |
CN104624238B (zh) * | 2015-01-03 | 2017-06-16 | 浙江理工大学 | 一种聚丙烯腈基仿生催化纤维及制备方法 |
CN104607245B (zh) * | 2015-01-03 | 2017-06-16 | 浙江理工大学 | 一种纤维素基仿生催化纤维及制备方法 |
CN104624237B (zh) * | 2015-01-03 | 2017-06-16 | 浙江理工大学 | 具有高催化活性的仿生催化碳纤维材料及制备方法 |
WO2018227053A1 (en) * | 2017-06-09 | 2018-12-13 | Bristol-Myers Squibb Company | Non-chromatographic purification of macrocyclic peptides by a resin catch and release |
CN107759799B (zh) * | 2017-09-21 | 2020-10-23 | 中山大学 | 一种三联吡啶钌-赖氨酸聚合物固相合成方法 |
CN108558999B (zh) * | 2018-04-18 | 2019-07-30 | 东莞理工学院 | 一种改良纤维素及其制备方法和应用 |
WO2019200764A1 (zh) * | 2018-04-18 | 2019-10-24 | 东莞理工学院 | 改良纤维素及其制备方法和应用 |
CN108299565B (zh) * | 2018-04-18 | 2019-07-30 | 东莞理工学院 | 一种Wang linker修饰的改良纤维素及其制备方法和应用 |
CN108359018B (zh) * | 2018-04-18 | 2019-07-30 | 东莞理工学院 | 一种Rink Amide linker修饰的改良纤维素及其制备方法和应用 |
AU2019355579A1 (en) * | 2018-10-05 | 2021-05-06 | Board Of Regents, The University Of Texas System | Solid-phase N-terminal peptide capture and release |
US20220048010A1 (en) * | 2018-12-17 | 2022-02-17 | Chreto Aps | Ligand linker substrate |
EP3986465A1 (en) | 2019-06-18 | 2022-04-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as his-tagged proteins via metal complex reagents |
CN111718435B (zh) * | 2020-06-17 | 2021-12-28 | 西北大学 | 一种抗菌高分子聚乙烯醇材料及方法和应用 |
CN114324658B (zh) * | 2021-12-30 | 2023-11-14 | 福州大学 | 三聚氰胺的分散固相萃取-高效液相色谱联用检测方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1304886C (en) * | 1986-07-10 | 1992-07-07 | Heinz Dobeli | Metal chelate resins |
US5047513A (en) * | 1986-07-10 | 1991-09-10 | Hoffmann-La Roche Inc. | Metal chelate resins |
EP0583894A3 (en) * | 1992-07-29 | 1995-09-06 | Hybritech Inc | Method of immobilizing and orienting molecules by use of metal chelating moieties to facilitate atomic force microscopy of proteins and molecular scale manipulation |
WO2002087304A2 (de) * | 2001-04-30 | 2002-11-07 | Frohnhofen, Wilfried | Il2-peptide; von interleukin 2 abgeleitete peptide und peptid-dimere |
CA2493019A1 (en) * | 2002-08-06 | 2004-02-19 | Aplagen Gmbh | Binding molecules |
EP1479688A1 (en) * | 2003-05-23 | 2004-11-24 | AplaGen GmbH | Solid-phase peptide synthesis using non-covalent attachment of the growing peptide chain |
-
2004
- 2004-05-24 EA EA200501852A patent/EA008305B1/ru not_active IP Right Cessation
- 2004-05-24 CN CN200480014163XA patent/CN1795202B/zh not_active Expired - Fee Related
- 2004-05-24 EP EP04734508A patent/EP1626982B1/en not_active Expired - Lifetime
- 2004-05-24 SI SI200430386T patent/SI1626982T1/sl unknown
- 2004-05-24 DE DE602004006254T patent/DE602004006254T2/de not_active Expired - Lifetime
- 2004-05-24 CA CA002524693A patent/CA2524693A1/en not_active Abandoned
- 2004-05-24 AT AT04734508T patent/ATE361311T1/de not_active IP Right Cessation
- 2004-05-24 PL PL04734508T patent/PL1626982T3/pl unknown
- 2004-05-24 DK DK04734508T patent/DK1626982T3/da active
- 2004-05-24 MX MXPA05012072A patent/MXPA05012072A/es active IP Right Grant
- 2004-05-24 AU AU2004240766A patent/AU2004240766A1/en not_active Abandoned
- 2004-05-24 EP EP07107250A patent/EP1810977A3/en not_active Withdrawn
- 2004-05-24 US US10/556,427 patent/US20070027303A1/en not_active Abandoned
- 2004-05-24 WO PCT/EP2004/005568 patent/WO2004104023A2/en active IP Right Grant
- 2004-05-24 ES ES04734508T patent/ES2287728T3/es not_active Expired - Lifetime
- 2004-05-24 JP JP2006529910A patent/JP2007528870A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
SI1626982T1 (sl) | 2007-10-31 |
JP2007528870A (ja) | 2007-10-18 |
WO2004104023A2 (en) | 2004-12-02 |
AU2004240766A1 (en) | 2004-12-02 |
DK1626982T3 (da) | 2007-09-10 |
CN1795202A (zh) | 2006-06-28 |
EP1810977A2 (en) | 2007-07-25 |
CN1795202B (zh) | 2010-05-26 |
EP1626982A2 (en) | 2006-02-22 |
DE602004006254D1 (de) | 2007-06-14 |
CA2524693A1 (en) | 2004-12-02 |
EP1626982B1 (en) | 2007-05-02 |
EP1810977A3 (en) | 2009-05-20 |
DE602004006254T2 (de) | 2008-01-10 |
ES2287728T3 (es) | 2007-12-16 |
EA200501852A1 (ru) | 2006-06-30 |
WO2004104023A3 (en) | 2005-06-02 |
PL1626982T3 (pl) | 2007-10-31 |
ATE361311T1 (de) | 2007-05-15 |
EA008305B1 (ru) | 2007-04-27 |
US20070027303A1 (en) | 2007-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
HH | Correction or change in general |