EA200501852A1 - Синтез пептидов - Google Patents

Синтез пептидов

Info

Publication number
EA200501852A1
EA200501852A1 EA200501852A EA200501852A EA200501852A1 EA 200501852 A1 EA200501852 A1 EA 200501852A1 EA 200501852 A EA200501852 A EA 200501852A EA 200501852 A EA200501852 A EA 200501852A EA 200501852 A1 EA200501852 A1 EA 200501852A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid phase
anchoring part
peptide synthesis
peptides
activated solid
Prior art date
Application number
EA200501852A
Other languages
English (en)
Other versions
EA008305B1 (ru
Inventor
Андреас Рибка
Ханс-Георг Франк
Франц-Петер Брахт
Удо Хаберль
Original Assignee
Аплаген Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аплаген Гмбх filed Critical Аплаген Гмбх
Publication of EA200501852A1 publication Critical patent/EA200501852A1/ru
Publication of EA008305B1 publication Critical patent/EA008305B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Применение активированной твердой фазы и якорной части, которую присоединяют к пептиду, для твердофазного синтеза пептидов, причем якорную часть координационно и обратимо присоединяют к активированной твердой фазе. Кроме того, предлагается способ конкурентного отщепления упомянутой якорной части для очистки и рефолдинга указанных пептидов. Предлагаются пептиды с якорной частью для координационного и обратимого присоединения указанных пептидов к активированной твердой фазе.
EA200501852A 2003-05-23 2004-05-24 Синтез пептидов EA008305B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47272403P 2003-05-23 2003-05-23
EP03017839 2003-08-05
EP04006195 2004-03-16
PCT/EP2004/005568 WO2004104023A2 (en) 2003-05-23 2004-05-24 Metal chelate complexes immobilized on solid supports for peptide preparation

Publications (2)

Publication Number Publication Date
EA200501852A1 true EA200501852A1 (ru) 2006-06-30
EA008305B1 EA008305B1 (ru) 2007-04-27

Family

ID=37695241

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501852A EA008305B1 (ru) 2003-05-23 2004-05-24 Синтез пептидов

Country Status (15)

Country Link
US (1) US20070027303A1 (ru)
EP (2) EP1810977A3 (ru)
JP (1) JP2007528870A (ru)
CN (1) CN1795202B (ru)
AT (1) ATE361311T1 (ru)
AU (1) AU2004240766A1 (ru)
CA (1) CA2524693A1 (ru)
DE (1) DE602004006254T2 (ru)
DK (1) DK1626982T3 (ru)
EA (1) EA008305B1 (ru)
ES (1) ES2287728T3 (ru)
MX (1) MXPA05012072A (ru)
PL (1) PL1626982T3 (ru)
SI (1) SI1626982T1 (ru)
WO (1) WO2004104023A2 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261475A1 (en) * 2004-02-13 2005-11-24 Harvard Medical School Solid-phase capture-release-tag methods for phosphoproteomic analyses
WO2006056443A2 (en) * 2004-11-24 2006-06-01 Aplagen Gmbh Method for solid-phase peptide synthesis and purification
CA2651070A1 (en) * 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
GB0610479D0 (en) * 2006-05-26 2006-07-05 Ge Healthcare Bio Sciences Ab A method for generating metal chelating affinity ligands
WO2009008802A1 (en) * 2007-07-09 2009-01-15 Ge Healthcare Bio-Sciences Ab Method for preparation of a biomolecule adsorbent
EP2183049B2 (en) 2007-08-06 2019-03-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of immobilized chelator for purification of recombinant proteins by immobilized metal ion chromatography and method of purifying recombinant proteins
CN103965285B (zh) * 2013-02-06 2016-12-28 北京大学 一种以超顺磁纳米颗粒为固相进行多肽合成及同步构建多肽磁纳米探针的方法
CN103652892B (zh) * 2013-12-03 2015-07-08 江西益佰年药业股份有限公司 乌鸡肽铁螯合物粉制备方法
EP3137115B1 (en) * 2014-05-01 2020-10-14 Ionis Pharmaceuticals, Inc. Method for synthesis of reactive conjugate clusters
CN104624238B (zh) * 2015-01-03 2017-06-16 浙江理工大学 一种聚丙烯腈基仿生催化纤维及制备方法
CN104607245B (zh) * 2015-01-03 2017-06-16 浙江理工大学 一种纤维素基仿生催化纤维及制备方法
CN104624237B (zh) * 2015-01-03 2017-06-16 浙江理工大学 具有高催化活性的仿生催化碳纤维材料及制备方法
WO2018227053A1 (en) * 2017-06-09 2018-12-13 Bristol-Myers Squibb Company Non-chromatographic purification of macrocyclic peptides by a resin catch and release
CN107759799B (zh) * 2017-09-21 2020-10-23 中山大学 一种三联吡啶钌-赖氨酸聚合物固相合成方法
CN108359018B (zh) * 2018-04-18 2019-07-30 东莞理工学院 一种Rink Amide linker修饰的改良纤维素及其制备方法和应用
CN108299565B (zh) * 2018-04-18 2019-07-30 东莞理工学院 一种Wang linker修饰的改良纤维素及其制备方法和应用
CN108558999B (zh) * 2018-04-18 2019-07-30 东莞理工学院 一种改良纤维素及其制备方法和应用
US20200308310A1 (en) * 2018-04-18 2020-10-01 Dongguan University Of Technology Novel modified cellulose, method for preparing the same and use thereof
GB2593091B (en) * 2018-10-05 2023-12-20 Univ Texas Solid-phase N-terminal peptide capture and release
CN114456192A (zh) * 2018-12-17 2022-05-10 3M创新产权公司 化合物、聚合物、配体官能化基材及用途
CN113993548A (zh) 2019-06-18 2022-01-28 马克思—普朗克科学促进协会公司 标记物和/或载体与靶分子例如带His-标签的蛋白质通过金属配合物试剂的位点特异性动力学惰性缀合
CN111718435B (zh) * 2020-06-17 2021-12-28 西北大学 一种抗菌高分子聚乙烯醇材料及方法和应用
CN114324658B (zh) * 2021-12-30 2023-11-14 福州大学 三聚氰胺的分散固相萃取-高效液相色谱联用检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1304886C (en) * 1986-07-10 1992-07-07 Heinz Dobeli Metal chelate resins
EP0583894A3 (en) * 1992-07-29 1995-09-06 Hybritech Inc Method of immobilizing and orienting molecules by use of metal chelating moieties to facilitate atomic force microscopy of proteins and molecular scale manipulation
WO2002087304A2 (de) * 2001-04-30 2002-11-07 Frohnhofen, Wilfried Il2-peptide; von interleukin 2 abgeleitete peptide und peptid-dimere
CA2493019A1 (en) * 2002-08-06 2004-02-19 Aplagen Gmbh Binding molecules
EP1479688A1 (en) * 2003-05-23 2004-11-24 AplaGen GmbH Solid-phase peptide synthesis using non-covalent attachment of the growing peptide chain

Also Published As

Publication number Publication date
DE602004006254D1 (de) 2007-06-14
EP1626982A2 (en) 2006-02-22
JP2007528870A (ja) 2007-10-18
WO2004104023A3 (en) 2005-06-02
WO2004104023A2 (en) 2004-12-02
PL1626982T3 (pl) 2007-10-31
MXPA05012072A (es) 2006-02-22
DE602004006254T2 (de) 2008-01-10
US20070027303A1 (en) 2007-02-01
CN1795202B (zh) 2010-05-26
CN1795202A (zh) 2006-06-28
AU2004240766A1 (en) 2004-12-02
CA2524693A1 (en) 2004-12-02
EP1810977A3 (en) 2009-05-20
DK1626982T3 (da) 2007-09-10
EP1626982B1 (en) 2007-05-02
EA008305B1 (ru) 2007-04-27
SI1626982T1 (sl) 2007-10-31
EP1810977A2 (en) 2007-07-25
ES2287728T3 (es) 2007-12-16
ATE361311T1 (de) 2007-05-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU