MXPA04012167A - Metodos para tratar angiogenesis, crecimeinto tumoral y metastasis. - Google Patents
Metodos para tratar angiogenesis, crecimeinto tumoral y metastasis.Info
- Publication number
- MXPA04012167A MXPA04012167A MXPA04012167A MXPA04012167A MXPA04012167A MX PA04012167 A MXPA04012167 A MX PA04012167A MX PA04012167 A MXPA04012167 A MX PA04012167A MX PA04012167 A MXPA04012167 A MX PA04012167A MX PA04012167 A MXPA04012167 A MX PA04012167A
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- patient
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- carbon monoxide
- cancer
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| GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| EP1404811B1 (en) * | 2001-06-21 | 2008-11-12 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
| US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| US7011854B2 (en) * | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| WO2003088981A1 (en) | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
| EA200401365A1 (ru) | 2002-04-15 | 2005-04-28 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Способы лечения илеуса |
| WO2003088748A1 (en) | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center | Use of heme oxygenase-1 and products of heme degradation |
| EA200401525A1 (ru) | 2002-05-17 | 2006-06-30 | Йейл Юниверсити | Способы лечения гепатита (варианты ) |
| WO2004000368A1 (en) * | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
| DE10230165A1 (de) * | 2002-07-04 | 2004-01-15 | Ino Therapeutics Gmbh | Verfahren und Vorrichtung zur Administration von Kohlenmonoxid |
| US20100158795A1 (en) * | 2008-06-12 | 2010-06-24 | Pulmonx | Methods and systems for assessing lung function and delivering therapeutic agents |
| EP1558084A4 (en) * | 2002-11-07 | 2008-04-30 | Univ Pittsburgh | TREATMENT OF HEMORRHAGIC SHOCK |
| GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
| CA2534415A1 (en) * | 2003-08-04 | 2005-02-17 | Northwick Park Institute For Medical Research | Therapeutic delivery of carbon monoxide |
| CN100475275C (zh) * | 2004-01-05 | 2009-04-08 | 董永华 | 肿瘤血管栓塞剂及其储存和释放装置 |
| JPWO2007073005A1 (ja) * | 2005-12-22 | 2009-06-04 | 学校法人慶應義塾 | メチル基転移反応調節物質 |
| GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| JP5552262B2 (ja) * | 2009-05-13 | 2014-07-16 | フクダ電子株式会社 | 肺疾患の治療に用いられる気体製剤 |
| CN109925318A (zh) * | 2011-01-14 | 2019-06-25 | 洛杉矶儿童医院 | 用于治疗包括镰状细胞疾病的疾病的一氧化碳溶液 |
| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
| WO2013022946A1 (en) | 2011-08-09 | 2013-02-14 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating dna damage |
| WO2018225785A1 (ja) * | 2017-06-06 | 2018-12-13 | 株式会社Ａｔｏｍｉｓ | ワクチン組成物 |
| WO2021105900A1 (en) * | 2019-11-25 | 2021-06-03 | Beyond Air, Inc. | System and method for delivery of gas to a tissue |
| US20230346831A1 (en) * | 2020-07-16 | 2023-11-02 | Cornell University | Methods for treating metastatic cancer using low dose carbon monoxide |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053590A (en) * | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| US4264739A (en) * | 1979-01-05 | 1981-04-28 | Merck & Co., Inc. | Sparger for cell culture system |
| US5240912A (en) * | 1983-05-09 | 1993-08-31 | Todaro George J | Transforming growth factor (TGF) peptides |
| US5084380A (en) * | 1985-01-29 | 1992-01-28 | Applied Biotechnology | Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins |
| US5449665A (en) * | 1985-09-24 | 1995-09-12 | Item Development Aktiebolag | Continuous intravenous infusion of adenosine to human patients undergoing percutaneous transluminal angioplasty |
| DE3739650C1 (de) * | 1987-11-23 | 1989-05-24 | Immuno Ag | Fermenter zum Zuechten von Zellkulturen |
| US5180366A (en) * | 1990-10-10 | 1993-01-19 | Woods W T | Apparatus and method for angioplasty and for preventing re-stenosis |
| US5792325A (en) * | 1990-11-15 | 1998-08-11 | Richardson, Jr.; William H. | Electric arc material processing system |
| US5293875A (en) * | 1992-06-16 | 1994-03-15 | Natus Medical Incorporated | In-vivo measurement of end-tidal carbon monoxide concentration apparatus and methods |
| BR9405798A (pt) * | 1993-02-22 | 1995-12-12 | Vivorx Pharmaceuticals Inc | Métodos para liberação in vivo de material biológico e composições úteis dos mesmos |
| US5763431A (en) * | 1993-08-20 | 1998-06-09 | Jackson; Meyer B. | Method for regulating neuropeptide hormone secretion |
| DE4421433C1 (de) * | 1994-06-18 | 1995-06-08 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Wirkstoffen, die Kohlenmonoxid-Quellen darstellen, Verfahren zu seiner Herstellung und seine Verwendung |
| US5476764A (en) * | 1994-09-16 | 1995-12-19 | The Regents Of The University Of California | Method using CO for extending the useful shelf-life of refrigerated red blood cells |
| US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| US5664563A (en) * | 1994-12-09 | 1997-09-09 | Cardiopulmonary Corporation | Pneumatic system |
| US5914316A (en) * | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
| US5712293A (en) * | 1995-06-07 | 1998-01-27 | Sepracor, Inc. | Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride |
| FR2735382B1 (fr) * | 1995-06-15 | 1997-07-25 | Air Liquide | Installation de production de monoxyde de carbone incorporant une unite de separation cryogenique |
| AU5938696A (en) * | 1995-06-30 | 1997-02-05 | Zymogenetics Inc. | 4-(2-(n-2-carboxamidoindole)aminoethyl)-benzenesulfonamides or sulfonylureas as pdgf antagonists |
| ATE331505T1 (de) * | 1996-04-05 | 2006-07-15 | Gen Hospital Corp | Behandlung einer hämoglobinstörung |
| US6069132A (en) * | 1996-08-14 | 2000-05-30 | Revanker; Ganapathi R. | Phosphazole compounds |
| US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
| US6316403B1 (en) * | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| EP1064277B1 (en) * | 1998-03-16 | 2005-06-15 | Celgene Corporation | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
| US6203991B1 (en) * | 1998-08-21 | 2001-03-20 | The Regents Of The University Of Michigan | Inhibition of smooth muscle cell migration by heme oxygenase I |
| US20050250688A1 (en) * | 1999-04-01 | 2005-11-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| US7632803B2 (en) * | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| WO2002080859A2 (en) * | 2001-03-20 | 2002-10-17 | Glaxo Group Limited | Inhalation drug combinations |
| CA2442457A1 (en) * | 2001-03-30 | 2002-10-10 | Roland Buelow | Carbon monoxide generating compounds for treatment of vascular, inflammatory and immune disorders |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| EP1395241B9 (en) * | 2001-05-25 | 2005-06-15 | Medtronic, Inc. | Implantable medical device with controllable gaseous agent release system |
| EP1404811B1 (en) * | 2001-06-21 | 2008-11-12 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
| US7069026B2 (en) * | 2001-06-28 | 2006-06-27 | Nokia Corporation | Geographic area assisted system selection for mobile stations |
| US7011854B2 (en) * | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| SG148850A1 (en) * | 2002-02-13 | 2009-01-29 | Beth Israel Hospital | Methods of treating vascular disease |
| WO2003088981A1 (en) * | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
| EA200401365A1 (ru) * | 2002-04-15 | 2005-04-28 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Способы лечения илеуса |
| EA200401525A1 (ru) * | 2002-05-17 | 2006-06-30 | Йейл Юниверсити | Способы лечения гепатита (варианты ) |
| WO2004000368A1 (en) * | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
| EP1558084A4 (en) * | 2002-11-07 | 2008-04-30 | Univ Pittsburgh | TREATMENT OF HEMORRHAGIC SHOCK |
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2003
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- 2003-06-05 CA CA002487413A patent/CA2487413A1/en not_active Abandoned
- 2003-06-05 EA EA200401622A patent/EA200401622A1/ru unknown
- 2003-06-05 EP EP03757348A patent/EP1509237A4/en not_active Withdrawn
- 2003-06-05 AU AU2003248621A patent/AU2003248621A1/en not_active Abandoned
- 2003-06-05 PL PL03374375A patent/PL374375A1/xx not_active Application Discontinuation
- 2003-06-05 CN CNA038188724A patent/CN1674922A/zh active Pending
- 2003-06-05 MX MXPA04012167A patent/MXPA04012167A/es not_active Application Discontinuation
- 2003-06-05 HR HR20041146A patent/HRP20041146A2/xx not_active Application Discontinuation
- 2003-06-05 WO PCT/US2003/017731 patent/WO2003103585A2/en not_active Ceased
- 2003-06-05 US US10/455,564 patent/US20040258772A1/en not_active Abandoned
- 2003-06-05 RS YUP-1053/04A patent/RS105304A/sr unknown
- 2003-06-05 UA UAA200500061A patent/UA87438C2/ru unknown
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2004
- 2004-12-07 NO NO20045354A patent/NO20045354L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2487413A1 (en) | 2003-12-18 |
| EA200401622A1 (ru) | 2005-06-30 |
| AU2003248621A1 (en) | 2003-12-22 |
| PL374375A1 (en) | 2005-10-17 |
| RS105304A (sr) | 2007-02-05 |
| HRP20041146A2 (en) | 2005-06-30 |
| CN1674922A (zh) | 2005-09-28 |
| UA87438C2 (ru) | 2009-07-27 |
| JP2005532351A (ja) | 2005-10-27 |
| US20040258772A1 (en) | 2004-12-23 |
| NO20045354L (no) | 2004-12-22 |
| EP1509237A2 (en) | 2005-03-02 |
| WO2003103585A2 (en) | 2003-12-18 |
| WO2003103585A3 (en) | 2004-08-26 |
| EP1509237A4 (en) | 2006-07-12 |
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