MXPA03010251A - Proceso para la preparacion de ribavirina. - Google Patents
Proceso para la preparacion de ribavirina.Info
- Publication number
- MXPA03010251A MXPA03010251A MXPA03010251A MXPA03010251A MXPA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- paper copy
- ribavirin
- preparation
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
Se describe un proceso para la preparacion de ribavirina en una escala industrial, el cual comprende la reaccion de glicosilacion de triazoles 3-substituidos en la presencia de un acido de Lewis. El proceso comprende a) la reaccion de un triazol de la formula (I) con una ribofuranosa protegida de la formula (II) b) la remocion de los grupos Pg y, opcionalmente, la conversion en un grupo carboxiamida del grupo Rz del compuesto obtenido de la formula (III). (Ver Formula I. II. III).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01830510A EP1281715B1 (en) | 2001-07-30 | 2001-07-30 | Process for the preparation of ribavirin |
PCT/IB2002/002950 WO2003011884A1 (en) | 2001-07-30 | 2002-07-29 | Process for the preparation of ribavirin |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010251A true MXPA03010251A (es) | 2004-03-16 |
Family
ID=8184638
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000382A MXPA04000382A (es) | 2001-07-30 | 2002-07-25 | Proceso para preparacion de l-ribavirina. |
MXPA03010251A MXPA03010251A (es) | 2001-07-30 | 2002-07-29 | Proceso para la preparacion de ribavirina. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000382A MXPA04000382A (es) | 2001-07-30 | 2002-07-25 | Proceso para preparacion de l-ribavirina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US7285660B2 (es) |
EP (2) | EP1281715B1 (es) |
JP (2) | JP2004538317A (es) |
KR (2) | KR20040031784A (es) |
CN (2) | CN1255420C (es) |
AT (2) | ATE252594T1 (es) |
AU (1) | AU2002328974A1 (es) |
BR (2) | BR0210278A (es) |
DE (2) | DE60101056T2 (es) |
ES (2) | ES2208540T3 (es) |
HU (2) | HUP0401615A2 (es) |
MX (2) | MXPA04000382A (es) |
WO (2) | WO2003011883A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005539032A (ja) * | 2002-08-12 | 2005-12-22 | エフ.ホフマン−ラ ロシュ アーゲー | リボフラノースの製造方法 |
WO2007007183A2 (en) * | 2005-07-08 | 2007-01-18 | Aurobindo Pharma Limited | Compositions of antiviral compound |
JP2008222630A (ja) * | 2007-03-12 | 2008-09-25 | Permachem Asia Ltd | 1−β−D−リボフラノシルー1,2,4−トリアゾール−3−カルボキサミドのR−II型結晶の製造法 |
CN101891786B (zh) * | 2010-08-04 | 2012-09-05 | 王明 | 一种利巴韦林化合物及其制法 |
EP2646453A1 (en) | 2010-11-30 | 2013-10-09 | Gilead Pharmasset LLC | Compounds |
CN102127134B (zh) * | 2010-12-02 | 2012-11-14 | 海南美兰史克制药有限公司 | 一种利巴韦林化合物及其方法 |
CN102532226B (zh) * | 2010-12-15 | 2014-05-07 | 上海迪赛诺医药发展有限公司 | 利巴韦林晶型及其制备方法 |
CN109134565A (zh) * | 2017-08-15 | 2019-01-04 | 李双喜 | 一种1/10水利巴韦林化合物及其药物组合物 |
CN109134566A (zh) * | 2017-08-18 | 2019-01-04 | 樊艳芳 | 一种1/20水利巴韦林化合物 |
CN108484691A (zh) * | 2018-06-28 | 2018-09-04 | 牡丹江师范学院 | 一种利巴韦林缩合物的化学合成方法 |
CN111647033A (zh) * | 2020-06-08 | 2020-09-11 | 济南明鑫制药股份有限公司 | 一锅法制备利巴韦林的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3798209A (en) * | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
JPS55160793A (en) * | 1979-05-29 | 1980-12-13 | Microbial Chem Res Found | Preparation of virazole |
JPS5931797A (ja) * | 1982-08-18 | 1984-02-20 | Sumitomo Chem Co Ltd | 新規1−置換イミダゾ−ルヌクレオシドおよびその製造法 |
JPS60252493A (ja) * | 1984-05-25 | 1985-12-13 | Takeda Chem Ind Ltd | シチジン誘導体の製造法 |
KR880011146A (ko) * | 1987-03-25 | 1988-10-26 | 엠.피.젝슨 | 3'-아지도-3'-디옥시티미딘의 신규 제조방법 및 이러한 공정에 유용한 중간체 |
CN1049435C (zh) * | 1994-11-09 | 2000-02-16 | 中国科学院上海药物研究所 | 含苯基和杂环基的青蒿素衍生物及其制备方法 |
EP1254911A1 (en) * | 1996-10-16 | 2002-11-06 | ICN Pharmaceuticals, Inc. | Monocyclic L-nucleosides, analogs and uses thereof |
SK284054B6 (sk) * | 1996-10-16 | 2004-08-03 | Icn Pharmaceuticals, Inc. | Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie |
-
2001
- 2001-07-30 EP EP01830510A patent/EP1281715B1/en not_active Expired - Lifetime
- 2001-07-30 ES ES01830510T patent/ES2208540T3/es not_active Expired - Lifetime
- 2001-07-30 DE DE60101056T patent/DE60101056T2/de not_active Expired - Lifetime
- 2001-07-30 AT AT01830510T patent/ATE252594T1/de not_active IP Right Cessation
-
2002
- 2002-07-25 AT AT02764788T patent/ATE286062T1/de not_active IP Right Cessation
- 2002-07-25 EP EP02764788A patent/EP1414836B1/en not_active Expired - Lifetime
- 2002-07-25 DE DE60202483T patent/DE60202483T2/de not_active Expired - Fee Related
- 2002-07-25 WO PCT/EP2002/008330 patent/WO2003011883A2/en active IP Right Grant
- 2002-07-25 HU HU0401615A patent/HUP0401615A2/hu unknown
- 2002-07-25 MX MXPA04000382A patent/MXPA04000382A/es active IP Right Grant
- 2002-07-25 ES ES02764788T patent/ES2233857T3/es not_active Expired - Lifetime
- 2002-07-25 JP JP2003517074A patent/JP2004538317A/ja active Pending
- 2002-07-25 US US10/485,436 patent/US7285660B2/en not_active Expired - Fee Related
- 2002-07-25 KR KR10-2004-7001404A patent/KR20040031784A/ko not_active Application Discontinuation
- 2002-07-25 CN CNB028149246A patent/CN1255420C/zh not_active Expired - Fee Related
- 2002-07-25 AU AU2002328974A patent/AU2002328974A1/en not_active Abandoned
- 2002-07-25 BR BR0210278-1A patent/BR0210278A/pt not_active IP Right Cessation
- 2002-07-29 US US10/485,335 patent/US7285659B2/en not_active Expired - Lifetime
- 2002-07-29 CN CNB028149254A patent/CN1255421C/zh not_active Expired - Fee Related
- 2002-07-29 KR KR1020047001334A patent/KR100953031B1/ko not_active IP Right Cessation
- 2002-07-29 WO PCT/IB2002/002950 patent/WO2003011884A1/en active Application Filing
- 2002-07-29 BR BR0209815-6A patent/BR0209815A/pt not_active IP Right Cessation
- 2002-07-29 HU HU0401899A patent/HUP0401899A2/hu unknown
- 2002-07-29 JP JP2003517075A patent/JP2004538318A/ja active Pending
- 2002-07-29 MX MXPA03010251A patent/MXPA03010251A/es active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA945193B (en) | Novel 1-substituted imidazole compounds as cytokine inhibitors. | |
MXPA03010251A (es) | Proceso para la preparacion de ribavirina. | |
CO5221089A1 (es) | Combinaciones de un derivado de fluorbenzotiazol y folpet con actividad fungicida | |
EP0654517A3 (de) | Umsetzungsprodukte aus einer Aluminiumverbindung, einer Bor enthaltenden Säure, einer Phosphor enthaltenden Säure und eines Amins. | |
AU1570901A (en) | Cryptographic module for secure processing of value-bearing items | |
AU1993900A (en) | Reactor for plasma assisted gas processing | |
GB2358395B (en) | Tetrahydrofuran-adducted group 11 ß-diketonate complexes as source reagents for chemical vapor depostion | |
PL355098A1 (en) | Imidazole compounds used as phosphodiesterase vii inhibitors | |
IL150061A0 (en) | Purine derivatives | |
AU8022598A (en) | Method for preparing an ultrapure hydrogen peroxide solution by ion exchange in the presence of ion acetate | |
AU8415698A (en) | Gas content scale for portable gas cylinders | |
AU9156298A (en) | Process for preparing l-ascorbic acid | |
IN187760B (es) | ||
EP1085015A3 (en) | Catalyst comprising a nitrogen-containing heterocylic compound | |
AP2000001859A0 (en) | Method for treating multiple sclerosis | |
AU5891600A (en) | Process for synthesizing oxadiazoles | |
AU2001252618A1 (en) | Cell proliferation inhibitors | |
PL343546A1 (en) | Processes for preparing intermediates | |
TR200200995T2 (tr) | 7-amino-3-metksimetil-3-sefem-4-karbosilik asitin hazırlanmasına yönelik proses. | |
IL148161A0 (en) | Process for the preparation of 2-cyanopyridines | |
IL136739A (en) | Diol compounds and processes for their preparation | |
AP9901637A0 (en) | Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid. | |
AU6686394A (en) | Preparation of fluoro-nucleosides and intermediates for use therein | |
AU6290398A (en) | Inclusion complexes in aqueous solution | |
JPS57116067A (en) | Novel 8-quinolinesulfonyl derivative, its synthesis and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |