MXPA03009644A - Grupos azabiciclicos sustituidos para el tratamiento de enfermedades. - Google Patents

Grupos azabiciclicos sustituidos para el tratamiento de enfermedades.

Info

Publication number
MXPA03009644A
MXPA03009644A MXPA03009644A MXPA03009644A MXPA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A
Authority
MX
Mexico
Prior art keywords
disease
treatment
receptor antagonists
substituted azabicyclic
acethylcholine receptor
Prior art date
Application number
MXPA03009644A
Other languages
English (en)
Spanish (es)
Inventor
Jon E Jacobsen
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MXPA03009644A publication Critical patent/MXPA03009644A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MXPA03009644A 2001-04-19 2002-04-18 Grupos azabiciclicos sustituidos para el tratamiento de enfermedades. MXPA03009644A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28495001P 2001-04-19 2001-04-19
US34890401P 2001-10-26 2001-10-26
PCT/US2002/008268 WO2002085901A1 (en) 2001-04-19 2002-04-18 Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists)

Publications (1)

Publication Number Publication Date
MXPA03009644A true MXPA03009644A (es) 2004-01-29

Family

ID=26962909

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03009644A MXPA03009644A (es) 2001-04-19 2002-04-18 Grupos azabiciclicos sustituidos para el tratamiento de enfermedades.

Country Status (11)

Country Link
US (1) US6869946B2 (enExample)
EP (1) EP1389208B1 (enExample)
JP (1) JP2004526788A (enExample)
AR (1) AR035817A1 (enExample)
AT (1) ATE314367T1 (enExample)
CA (1) CA2439960A1 (enExample)
DE (1) DE60208366T2 (enExample)
ES (1) ES2254723T3 (enExample)
MX (1) MXPA03009644A (enExample)
PE (1) PE20021019A1 (enExample)
WO (1) WO2002085901A1 (enExample)

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WO2004052889A1 (en) * 2002-12-06 2004-06-24 Pharmacia & Upjohn Company Llc Compounds as radioligands for the diagnosis of disease
MXPA05007689A (es) * 2003-01-22 2005-09-30 Pharmacia & Upjohn Co Llc Tratamiento de enfermedades con agonistas completos del receptor alfa-7 de nach.
GB0310867D0 (en) * 2003-05-12 2003-06-18 Novartis Ag Organic compounds
PL1697378T3 (pl) 2003-12-22 2008-04-30 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania
WO2005092890A2 (en) 2004-03-25 2005-10-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
EP1736156A4 (en) * 2004-04-15 2010-06-16 Eisai R&D Man Co Ltd COMPOSITION CONTAINING 4-AMINO-5-CHLORO-N-¬ (1R, 3R, 5S) -8-METHYL-8-AZABICYCLO-3.2.1 OCT-3-YL-2-β-methyl-2-ynyloxy BENZAMIDE STABILIZED
DE602005024677D1 (de) * 2004-04-22 2010-12-23 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen
RU2386633C2 (ru) 2004-05-07 2010-04-20 Мемори Фармасьютиклз Корпорейшн 1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения
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GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0424564D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
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US7732607B2 (en) * 2005-08-22 2010-06-08 Anatoly Mazurov Heteroaryl-substituted diazatricycloalkanes and methods of use thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
JP5172124B2 (ja) * 2006-09-29 2013-03-27 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP5232374B2 (ja) * 2006-09-29 2013-07-10 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
EP2271344A4 (en) 2008-03-31 2011-04-27 Univ South Florida METHOD FOR TREATING ILLNESS-RELATED ATAXIA AND NON-ATTACHIC IMBALANCE
JP2011520964A (ja) * 2008-05-23 2011-07-21 ユニバーシティ・オブ・サウス・フロリダ ニコチン性アセチルコリン受容体活性を有する化合物を用いる末梢感覚神経喪失の治療方法
TW201031664A (en) * 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
TWI519532B (zh) 2010-05-17 2016-02-01 艾維沃製藥公司 （Ｒ）－７－氯－Ｎ－（啶－３－基）苯並［b］噻吩－２－羧醯胺鹽酸鹽單水合物之結晶形體
WO2012177263A1 (en) * 2011-06-24 2012-12-27 Intra-Cellular Therapies, Inc. Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists
RU2017136693A (ru) 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
CA2971413A1 (en) * 2014-12-16 2016-06-23 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法

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Also Published As

Publication number Publication date
EP1389208B1 (en) 2005-12-28
DE60208366D1 (de) 2006-02-02
US6869946B2 (en) 2005-03-22
ATE314367T1 (de) 2006-01-15
AR035817A1 (es) 2004-07-14
JP2004526788A (ja) 2004-09-02
EP1389208A1 (en) 2004-02-18
US20030055043A1 (en) 2003-03-20
ES2254723T3 (es) 2006-06-16
PE20021019A1 (es) 2002-11-13
DE60208366T2 (de) 2006-07-06
WO2002085901A8 (en) 2003-12-24
CA2439960A1 (en) 2002-10-31
WO2002085901A1 (en) 2002-10-31

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