MXPA03005355A - Pirroloquinolinas y piridoquinolinas sustituidas como agonistas y antagonistas de serotonina. - Google Patents

Pirroloquinolinas y piridoquinolinas sustituidas como agonistas y antagonistas de serotonina.

Info

Publication number
MXPA03005355A
MXPA03005355A MXPA03005355A MXPA03005355A MXPA03005355A MX PA03005355 A MXPA03005355 A MX PA03005355A MX PA03005355 A MXPA03005355 A MX PA03005355A MX PA03005355 A MXPA03005355 A MX PA03005355A MX PA03005355 A MXPA03005355 A MX PA03005355A
Authority
MX
Mexico
Prior art keywords
disorders
antagonists
novel compounds
serotonin agonists
pyridoquinolines
Prior art date
Application number
MXPA03005355A
Other languages
English (en)
Inventor
Lee Taekyu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA03005355A publication Critical patent/MXPA03005355A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

Abstract

La presente invencion esta dirigida a ciertos compuestos novedosos representados por la formula estructural (I) o las sales farmaceuticamente aceptables de los mismos, en donde R1, R6a, R6b, R7, R8, R9, X, b, m y n son como se describen en la presente. La invencion esta tambien relacionada con las formulaciones farmaceuticas que comprenden estos novedosos compuestos como ingredientes activos, y el uso de los nuevos compuestos y sus formulaciones en el tratamiento de ciertos desordenes. Los compuestos de esta invencion son agonistas o antagonistas de serotonina y son utiles en el control y prevencion de desordenes del sistema nervioso central incluyendo obesidad, ansiedad, depresion, psicosis, esquizofrenia, desordenes de sueno, desordenes sexuales, migrana, condiciones asociadas con dolor cefalico, fobias sociales y desordenes gastrointestinales tales como disfuncion de la motilidad del tracto gastrointestinal.
MXPA03005355A 2000-12-20 2001-12-19 Pirroloquinolinas y piridoquinolinas sustituidas como agonistas y antagonistas de serotonina. MXPA03005355A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25674500P 2000-12-20 2000-12-20
PCT/US2001/049380 WO2002059124A2 (en) 2000-12-20 2001-12-19 Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists

Publications (1)

Publication Number Publication Date
MXPA03005355A true MXPA03005355A (es) 2004-05-27

Family

ID=22973430

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03005355A MXPA03005355A (es) 2000-12-20 2001-12-19 Pirroloquinolinas y piridoquinolinas sustituidas como agonistas y antagonistas de serotonina.

Country Status (23)

Country Link
US (1) US6777406B2 (es)
EP (1) EP1399445B9 (es)
JP (1) JP4386639B2 (es)
KR (1) KR20030070590A (es)
AT (1) ATE438646T1 (es)
AU (1) AU2002246726B2 (es)
BG (1) BG107863A (es)
BR (1) BR0116348A (es)
CA (1) CA2432181C (es)
CZ (1) CZ20031707A3 (es)
DE (1) DE60139511D1 (es)
EE (1) EE200300303A (es)
ES (1) ES2329553T4 (es)
HU (1) HUP0303530A3 (es)
IL (1) IL156261A0 (es)
IS (1) IS6851A (es)
MX (1) MXPA03005355A (es)
NO (1) NO20032798L (es)
PL (1) PL366627A1 (es)
RU (1) RU2003121306A (es)
SK (1) SK7032003A3 (es)
WO (1) WO2002059124A2 (es)
ZA (1) ZA200304304B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR031200A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
AR031199A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
AR031202A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
EP2400300A1 (en) 2004-08-25 2011-12-28 Takeda Pharmaceutical Company Limited Method of screening preventives/remedies for stress urinary incontinence
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
WO2007112000A2 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain
US20070225279A1 (en) * 2006-03-24 2007-09-27 Wyeth Therapeutic combinations for the treatment of depression
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
AU2010303270A1 (en) 2009-10-09 2012-05-03 Zafgen Corporation Sulphone compounds for use in the treatment of obesity
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
KR20130043207A (ko) 2010-07-22 2013-04-29 자프겐 인크. 트리시클릭 화합물 및 이의 제조 및 사용 방법
JP6058557B2 (ja) 2011-01-26 2017-01-11 ザフゲン，インコーポレイテッド テトラゾール化合物ならびにその作製方法および使用方法
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
BR112013028534A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos
EP2804856B1 (en) 2012-01-18 2017-03-15 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
JP6035347B2 (ja) 2012-01-18 2016-11-30 ザフゲン，インコーポレイテッド 三環式スルホンアミド化合物ならびにその作製および使用方法
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
CA2890342A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CN104918615B (zh) 2012-11-05 2018-10-12 扎夫根股份有限公司 治疗肝病的方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2981266B1 (en) * 2013-03-04 2018-01-03 Daya CNS LLC Pentacyclic pyridoindolobenz[b,d]azepine derivatives and uses thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE
CN109897039B (zh) * 2019-03-13 2021-03-30 中国科学院化学研究所 一种制备吡咯并[3,2,1-ij]喹啉酮化合物的方法
IL307607A (en) * 2021-04-13 2023-12-01 Univ California Tetracyclic compounds for the treatment of brain disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183936A (en) 1972-06-19 1980-01-15 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US4013652A (en) 1972-06-19 1977-03-22 Endo Laboratories, Inc. Pyridopyrrolobenzoxazine
US4115577A (en) 1972-06-19 1978-09-19 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US3914421A (en) 1972-06-19 1975-10-21 Endo Lab Pyridopyrrolobenzheterocycles for combatting depression
US4238607A (en) 1972-06-19 1980-12-09 Endo Laboratories Inc. Pyridopyrrolo benzheterocycles
US4219550A (en) 1978-11-09 1980-08-26 E. I. Du Pont De Nemours And Company Cis- and trans- octahydropyridopyrrolobenzheterocycles
HUT61548A (en) * 1990-08-27 1993-01-28 Sandoz Ag Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds

Also Published As

Publication number Publication date
SK7032003A3 (en) 2004-04-06
IL156261A0 (en) 2004-01-04
BG107863A (en) 2004-06-30
RU2003121306A (ru) 2005-03-10
CA2432181A1 (en) 2002-08-01
HUP0303530A3 (en) 2012-10-29
ES2329553T4 (es) 2010-12-07
WO2002059124A3 (en) 2004-01-08
EP1399445B9 (en) 2010-07-21
CZ20031707A3 (cs) 2003-11-12
HUP0303530A2 (hu) 2004-01-28
NO20032798L (no) 2003-08-19
KR20030070590A (ko) 2003-08-30
NO20032798D0 (no) 2003-06-19
WO2002059124A2 (en) 2002-08-01
US6777406B2 (en) 2004-08-17
ATE438646T1 (de) 2009-08-15
IS6851A (is) 2003-06-18
ZA200304304B (en) 2004-09-02
US20040092502A1 (en) 2004-05-13
JP4386639B2 (ja) 2009-12-16
EP1399445A2 (en) 2004-03-24
AU2002246726B2 (en) 2007-03-01
EE200300303A (et) 2003-12-15
CA2432181C (en) 2009-11-17
DE60139511D1 (de) 2009-09-17
PL366627A1 (en) 2005-02-07
BR0116348A (pt) 2004-11-23
JP2004528290A (ja) 2004-09-16
ES2329553T3 (es) 2009-11-27
EP1399445B1 (en) 2009-08-05

Similar Documents

Publication Publication Date Title
MXPA03005355A (es) Pirroloquinolinas y piridoquinolinas sustituidas como agonistas y antagonistas de serotonina.
MXPA01012914A (es) Gama-carbolinas fundidas de heterociclo substituido.
MXPA03005438A (es) Pirioindoles substituidos como agonistas y antagonistas de serotonina.
ATE509929T1 (de) Substituierte tricyclische gamma-carbolineals serotonin-rezeptor-agonisten und antagonisten
RS20100338A (en) FLUOROSUPSTITUTIONED CYCLOALCANOINDOLES AND THEIR USE AS AN ANTAGONISTS OF PROSTAGLAND D2 RECEPTORS
HK1098460A1 (en) Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders
IS6850A (is) Tengdar pýrazínóquínoxalín afleiður sem gerandefni og mótefni serótonín viðtaka
HUP0303316A2 (hu) Aril- és amino-aril-szubsztituált szerotoninreceptor agonista és antagonista ligandumok és ezeket tartalmazó gyógyszerkészítmények
GB0311349D0 (en) Therapeutic agents, compositions, preparations and uses