MXPA02009743A - Combinaciones terapeuticas de agentes antihipertensivos y antiagiogenicos. - Google Patents

Combinaciones terapeuticas de agentes antihipertensivos y antiagiogenicos.

Info

Publication number
MXPA02009743A
MXPA02009743A MXPA02009743A MXPA02009743A MXPA02009743A MX PA02009743 A MXPA02009743 A MX PA02009743A MX PA02009743 A MXPA02009743 A MX PA02009743A MX PA02009743 A MXPA02009743 A MX PA02009743A MX PA02009743 A MXPA02009743 A MX PA02009743A
Authority
MX
Mexico
Prior art keywords
carbon atoms
alkyl
methoxy
quinazoline
agent
Prior art date
Application number
MXPA02009743A
Other languages
English (en)
Spanish (es)
Inventor
Jon Owen Curwen
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA02009743A publication Critical patent/MXPA02009743A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MXPA02009743A 2000-04-05 2001-04-02 Combinaciones terapeuticas de agentes antihipertensivos y antiagiogenicos. MXPA02009743A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0008269.3A GB0008269D0 (en) 2000-04-05 2000-04-05 Combination chemotherapy
PCT/GB2001/001522 WO2001074360A1 (en) 2000-04-05 2001-04-02 Therapeutic combinations of antihypertensive and antiangiogenic agents

Publications (1)

Publication Number Publication Date
MXPA02009743A true MXPA02009743A (es) 2003-03-27

Family

ID=9889176

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02009743A MXPA02009743A (es) 2000-04-05 2001-04-02 Combinaciones terapeuticas de agentes antihipertensivos y antiagiogenicos.

Country Status (29)

Country Link
US (1) US7829573B2 (enExample)
EP (3) EP1658849A3 (enExample)
JP (1) JP2003528917A (enExample)
KR (2) KR20080034523A (enExample)
CN (1) CN1431902A (enExample)
AT (1) ATE355065T1 (enExample)
AU (2) AU2001244386B2 (enExample)
BR (1) BR0109729A (enExample)
CA (1) CA2401854A1 (enExample)
CY (1) CY1107615T1 (enExample)
CZ (1) CZ299410B6 (enExample)
DE (1) DE60126923T2 (enExample)
DK (1) DK1272186T3 (enExample)
EE (1) EE200200578A (enExample)
ES (1) ES2280349T3 (enExample)
GB (1) GB0008269D0 (enExample)
HU (1) HUP0300426A2 (enExample)
IL (1) IL151503A0 (enExample)
IS (2) IS2455B (enExample)
MX (1) MXPA02009743A (enExample)
NO (2) NO323467B1 (enExample)
NZ (2) NZ534455A (enExample)
PL (1) PL357605A1 (enExample)
PT (1) PT1272186E (enExample)
RU (1) RU2002129353A (enExample)
SI (1) SI1272186T1 (enExample)
SK (1) SK14302002A3 (enExample)
WO (1) WO2001074360A1 (enExample)
ZA (1) ZA200206959B (enExample)

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BRPI0516052A (pt) 2004-09-27 2008-08-19 Astrazeneca Ab uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e de imatinib, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente
GB0424339D0 (en) 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
WO2007003933A2 (en) 2005-07-06 2007-01-11 Astrazeneca Ab Combination therapy of cancer with azd2171 and gemcitabine
CN101370519B (zh) 2005-12-15 2013-07-24 阿斯利康(瑞典)有限公司 治疗癌症的促血管生成素-2拮抗剂和VEGF-A、KDR和/或Flt1拮抗剂的组合
EP1971338B8 (en) 2005-12-22 2011-09-21 AstraZeneca AB Combination of zd6474 and pemetrexed
PT1965801E (pt) 2005-12-22 2011-05-25 Astrazeneca Ab Combina??o de azd2171 e pemetrexed
US20100092466A1 (en) 2006-09-29 2010-04-15 Anderson Joseph Ryan Combination of zd6474 and bevacizumab for cancer therapy
WO2008125820A1 (en) 2007-04-13 2008-10-23 Astrazeneca Ab Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii

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CY1107615T1 (el) 2013-03-13
ZA200206959B (en) 2003-12-01
AU2001244386B2 (en) 2005-01-27
IS2455B (is) 2008-11-15
RU2002129353A (ru) 2004-03-20
WO2001074360A1 (en) 2001-10-11
PL357605A1 (en) 2004-07-26
EP1272186A1 (en) 2003-01-08
NO326277B1 (no) 2008-10-27
ES2280349T3 (es) 2007-09-16
EE200200578A (et) 2004-06-15
EP1658849A2 (en) 2006-05-24
DK1272186T3 (da) 2007-05-21
NZ520938A (en) 2005-08-26
SK14302002A3 (sk) 2003-05-02
KR20080034523A (ko) 2008-04-21
DE60126923D1 (de) 2007-04-12
AU4438601A (en) 2001-10-15
EP1790340A3 (en) 2009-03-18
NO20024814D0 (no) 2002-10-04
CZ299410B6 (cs) 2008-07-16
DE60126923T2 (de) 2007-10-31
EP1658849A3 (en) 2009-02-18
SI1272186T1 (sl) 2007-06-30
ATE355065T1 (de) 2006-03-15
CN1431902A (zh) 2003-07-23
CA2401854A1 (en) 2001-10-11
NO20024814L (no) 2002-11-12
BR0109729A (pt) 2003-02-04
EP1790340A2 (en) 2007-05-30
IL151503A0 (en) 2003-04-10
NO323467B1 (no) 2007-05-21
IS6557A (is) 2002-09-20
KR20030007491A (ko) 2003-01-23
PT1272186E (pt) 2007-04-30
NZ534455A (en) 2007-01-26
EP1272186B1 (en) 2007-02-28
US7829573B2 (en) 2010-11-09
HUP0300426A2 (hu) 2003-06-28
US20030144298A1 (en) 2003-07-31
NO20062050L (no) 2001-10-08
GB0008269D0 (en) 2000-05-24
KR100849149B1 (ko) 2008-07-31
JP2003528917A (ja) 2003-09-30

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