MXPA01009674A - Compuestos heterociclicos que se unen a receptores de quimiocina. - Google Patents
Compuestos heterociclicos que se unen a receptores de quimiocina.Info
- Publication number
- MXPA01009674A MXPA01009674A MXPA01009674A MXPA01009674A MXPA01009674A MX PA01009674 A MXPA01009674 A MX PA01009674A MX PA01009674 A MXPA01009674 A MX PA01009674A MX PA01009674 A MXPA01009674 A MX PA01009674A MX PA01009674 A MXPA01009674 A MX PA01009674A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic compounds
- chemokine recpetor
- binding heterocyclic
- binding
- recpetor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12582399P | 1999-03-24 | 1999-03-24 | |
PCT/CA2000/000321 WO2000056729A1 (en) | 1999-03-24 | 2000-03-24 | Chemokine recpetor binding heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA01009674A true MXPA01009674A (es) | 2003-07-21 |
Family
ID=22421586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA01009674A MXPA01009674A (es) | 1999-03-24 | 2000-03-24 | Compuestos heterociclicos que se unen a receptores de quimiocina. |
Country Status (22)
Country | Link |
---|---|
US (2) | US7629337B2 (es) |
EP (1) | EP1163238B1 (es) |
JP (1) | JP2003524620A (es) |
KR (1) | KR100766289B1 (es) |
CN (1) | CN1219780C (es) |
AP (1) | AP1654A (es) |
AT (1) | ATE327988T1 (es) |
AU (1) | AU775123B2 (es) |
BR (1) | BR0010655A (es) |
CA (1) | CA2368047A1 (es) |
CZ (1) | CZ20013421A3 (es) |
DE (1) | DE60028354T2 (es) |
ES (1) | ES2265923T3 (es) |
HK (1) | HK1043985B (es) |
HU (1) | HUP0200761A3 (es) |
IL (2) | IL145401A0 (es) |
MX (1) | MXPA01009674A (es) |
NO (1) | NO323703B1 (es) |
NZ (1) | NZ514709A (es) |
PL (1) | PL350998A1 (es) |
TR (1) | TR200102799T2 (es) |
WO (1) | WO2000056729A1 (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2362401A1 (en) * | 1999-02-04 | 2000-08-10 | Paul Fleming | G-protein coupled heptahelical receptor binding compounds and methods of use thereof |
MXPA01009674A (es) * | 1999-03-24 | 2003-07-21 | Anormed Inc | Compuestos heterociclicos que se unen a receptores de quimiocina. |
DE19939980A1 (de) | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
WO2002049993A2 (en) * | 2000-09-29 | 2002-06-27 | Neurogen Corporation | High affinity small molecule c5a receptor modulators |
AU2000276225B2 (en) * | 1999-09-28 | 2008-07-10 | Neurogen Corporation | High affinity small molecule C5A receptor modulators |
ATE487710T1 (de) * | 2000-09-15 | 2010-11-15 | Anormed Inc | Chemokin rezeptor bindende heterozyklische verbindungen |
SG126007A1 (en) | 2000-09-15 | 2006-10-30 | Anormed Inc | Chemokine receptor binding hetrocyclic compounds |
AU9355101A (en) | 2000-09-15 | 2002-03-26 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
EP1340749A4 (en) * | 2000-11-17 | 2007-09-05 | Takeda Pharmaceutical | isoxazole |
US7169750B2 (en) | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
ES2380009T3 (es) | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
US6825351B2 (en) | 2001-09-12 | 2004-11-30 | Anormed, Inc. | Synthesis of enantiomerically pure amino-substituted fused bicyclic rings |
US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
CA2467718C (en) | 2001-12-21 | 2011-04-26 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
AU2003249983A1 (en) * | 2002-07-18 | 2004-02-09 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
AU2003265625A1 (en) | 2002-08-21 | 2004-03-11 | Neurogen Corporation | Amino methyl imidazoles as c5a receptor modulators |
EP1550657A4 (en) * | 2002-09-11 | 2009-12-30 | Kureha Corp | AMINO COMPOUNDS AND THEIR USE |
US7759336B2 (en) | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
MXPA05009771A (es) | 2003-03-14 | 2005-10-26 | Ono Pharmaceutical Co | Derivados heterociclicos que contienen nitrogeno y medicamentos que los contienen como el ingrediente activo. |
US7504422B2 (en) | 2003-04-02 | 2009-03-17 | Taigen Biotechnology Co. Ltd. | Polyamine compounds |
EP1608352B1 (en) | 2003-04-02 | 2009-12-30 | Taigen Biotechnology | Polyamine compounds for treating chemokine receptor mediated diseases |
CA2520259A1 (en) | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
EP2364982A1 (en) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof |
EP2374804A1 (en) | 2003-04-22 | 2011-10-12 | Genzyme Corporation | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
US7501518B2 (en) | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
WO2005028467A1 (en) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
US7491735B2 (en) | 2003-12-11 | 2009-02-17 | Genzyme Corporation | Chemokine receptor binding compounds |
US7498346B2 (en) | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
CN1950343B (zh) * | 2004-03-10 | 2013-06-19 | 株式会社吴羽 | 胺系碱性化合物及其用途 |
KR20060131899A (ko) | 2004-03-15 | 2006-12-20 | 아노르메드 인코포레이티드 | Cxcr4 길항제의 합성방법 |
TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
DK1809622T3 (da) * | 2004-09-22 | 2010-11-08 | Janssen Pharmaceutica Nv | Inhibitorer af interaktionen mellem MDM2 og P53 |
JP5038905B2 (ja) * | 2005-01-07 | 2012-10-03 | エモリー・ユニバーシテイ | 医学的障害の治療用のcxcr4拮抗薬 |
AP2007004095A0 (en) * | 2005-01-07 | 2007-08-31 | Univ Emory | Cxcr4 antagonists for the treatment of hiv infection |
US7501526B2 (en) | 2005-01-20 | 2009-03-10 | Taigen Biotechnology | Synthesis of polyamine compounds |
TW200714610A (en) | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
EP1889622A4 (en) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
JP2008543858A (ja) | 2005-06-15 | 2008-12-04 | ジェンザイム・コーポレーション | ケモカインレセプター結合化合物 |
US20070043012A1 (en) | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
DK1942108T3 (da) | 2005-10-28 | 2013-12-09 | Ono Pharmaceutical Co | Forbindelse indeholdende basisk gruppe samt anvendelse deraf |
CN100387595C (zh) * | 2005-11-07 | 2008-05-14 | 青岛科技大学 | 一种含苯并三唑的三唑有机化合物、制备方法及应用 |
PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
CA2643744A1 (en) | 2006-02-27 | 2007-08-30 | Technische Universitaet Muenchen | Cancer imaging and treatment |
US8003642B2 (en) | 2006-03-10 | 2011-08-23 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
EP2042503B1 (en) | 2006-05-16 | 2013-01-30 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
AU2007262670B2 (en) | 2006-06-22 | 2012-12-20 | Prana Biotechnology Limited | Method of treatment of glioma brain tumour |
JP2009543802A (ja) * | 2006-07-11 | 2009-12-10 | エモリー・ユニバーシテイ | 医学的疾患の治療のためのジアジン及びトリアジン構造を含むcxcr4アンタゴニスト |
CA2659155A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1 |
JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
US8350042B2 (en) | 2008-01-31 | 2013-01-08 | The Regents Of The University Of California | Antiviral compounds for the treatment of HCV infection |
WO2009121063A2 (en) | 2008-03-28 | 2009-10-01 | Altiris Therapeutics | Chemokine receptor modulators |
WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
EP2348360B1 (en) * | 2010-01-25 | 2017-09-27 | Rohm and Haas Electronic Materials LLC | Photoresist comprising nitrogen-containing compound |
WO2013024022A1 (en) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
EP3134079A4 (en) * | 2014-04-23 | 2017-12-20 | X-RX Discovery, Inc. | Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases |
JP2017516858A (ja) * | 2014-05-30 | 2017-06-22 | ユニヴェルシテ・パリ・デカルト | Hiv感染症の治療に使用するための1,3ジアミノ官能性を有する環式化合物 |
EP3050574B1 (en) | 2015-01-28 | 2019-10-09 | Universite De Bordeaux | Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease |
AU2016269839B2 (en) | 2015-06-03 | 2021-07-08 | The University Of Queensland | Mobilizing agents and uses therefor |
CA3008272A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
JP6958820B2 (ja) | 2015-12-14 | 2021-11-02 | エックス4 ファーマシューティカルズ, インコーポレイテッド | がんを処置する方法 |
CN108883091A (zh) | 2015-12-22 | 2018-11-23 | X4 制药有限公司 | 用于治疗免疫缺陷病的方法 |
US10669270B2 (en) | 2016-03-14 | 2020-06-02 | Emory University | Amide-sulfamide derivatives, compositions, and uses related to CXCR4 inhibition |
CN109153722A (zh) | 2016-04-08 | 2019-01-04 | X4 制药有限公司 | 用于治疗癌症的方法 |
CN109641838A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
WO2017223229A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
TW201841916A (zh) | 2017-04-12 | 2018-12-01 | 美商麥珍塔治療學股份有限公司 | 芳香烴受體拮抗劑及其用途 |
CA3079405A1 (en) | 2017-10-31 | 2019-05-09 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
JP2021503008A (ja) | 2017-10-31 | 2021-02-04 | マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. | 造血幹細胞および前駆細胞移植療法のための組成物および方法 |
US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
EP3720494A2 (en) | 2017-12-06 | 2020-10-14 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
WO2019136159A1 (en) | 2018-01-03 | 2019-07-11 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
CN110787838B (zh) * | 2019-10-09 | 2021-10-29 | 江苏医药职业学院 | 一种双核配合物及其制备方法和应用 |
US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
JP2023523334A (ja) | 2020-04-27 | 2023-06-02 | マジェンタ セラピューティクス インコーポレイテッド | in vivoで造血幹細胞及び造血前駆細胞を形質導入するための方法及び組成物 |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
US20230416239A1 (en) * | 2020-11-12 | 2023-12-28 | Conservatoire National des Arts et Métiers | Compounds and methods for treating a cytokine-mediated disease |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
MX2023011963A (es) * | 2021-04-10 | 2023-10-19 | Sumitomo Pharma Co Ltd | Derivado biciclico de piridina. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7409399A (nl) * | 1973-07-19 | 1975-01-21 | Rhone Poulenc Sa | Werkwijze ter bereiding van thermostabiele har- sen en voorwerpen geheel of gedeeltelijk be- staande uit deze harsen. |
US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
AU7317391A (en) * | 1990-02-14 | 1991-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor of denatured ldl formation |
GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9200245D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
GB9400411D0 (en) * | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
AU4844396A (en) * | 1995-03-01 | 1996-09-18 | Kyowa Hakko Kogyo Co. Ltd. | Imidazoquinazoline derivatives |
GB9511357D0 (en) * | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
AU4779897A (en) * | 1996-10-02 | 1998-04-24 | Novartis Ag | Fused pyrazole derivatives and processes for their preparation |
JP3060214B2 (ja) * | 1997-04-10 | 2000-07-10 | 小野薬品工業株式会社 | 縮合ピペリジン化合物、その製造方法およびその化合物を有効成分とする薬剤 |
US5843146A (en) * | 1997-04-30 | 1998-12-01 | Medtronic Incorporated | Adjustable medical lead anchor |
CA2296314A1 (en) * | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
HUP0100199A2 (hu) | 1997-12-19 | 2001-04-28 | Takeda Chemical Industries, Ltd. | Anilid-származékot tartalmazó gyógyászati készítmény CCR5 antagonizálására |
EP1091942B1 (en) * | 1998-07-02 | 2005-03-30 | Neurosearch A/S | Potassium channel blocking agents |
BR9913374A (pt) * | 1998-08-20 | 2001-05-15 | Agouron Pharmaceticals Inc | Compostos de gnrh não peptìdicos, composição farmacêutica e métodos para regular a secreção de gonadotropinas em mamìferos |
MXPA01009674A (es) * | 1999-03-24 | 2003-07-21 | Anormed Inc | Compuestos heterociclicos que se unen a receptores de quimiocina. |
US6750348B1 (en) * | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
-
2000
- 2000-03-24 MX MXPA01009674A patent/MXPA01009674A/es active IP Right Grant
- 2000-03-24 CN CNB00807755XA patent/CN1219780C/zh not_active Expired - Fee Related
- 2000-03-24 CA CA002368047A patent/CA2368047A1/en not_active Abandoned
- 2000-03-24 WO PCT/CA2000/000321 patent/WO2000056729A1/en active IP Right Grant
- 2000-03-24 JP JP2000606590A patent/JP2003524620A/ja active Pending
- 2000-03-24 AU AU35460/00A patent/AU775123B2/en not_active Ceased
- 2000-03-24 IL IL14540100A patent/IL145401A0/xx active IP Right Grant
- 2000-03-24 HU HU0200761A patent/HUP0200761A3/hu unknown
- 2000-03-24 TR TR2001/02799T patent/TR200102799T2/xx unknown
- 2000-03-24 PL PL00350998A patent/PL350998A1/xx not_active Application Discontinuation
- 2000-03-24 EP EP00913979A patent/EP1163238B1/en not_active Expired - Lifetime
- 2000-03-24 KR KR1020017012166A patent/KR100766289B1/ko not_active IP Right Cessation
- 2000-03-24 NZ NZ514709A patent/NZ514709A/xx unknown
- 2000-03-24 DE DE60028354T patent/DE60028354T2/de not_active Expired - Lifetime
- 2000-03-24 ES ES00913979T patent/ES2265923T3/es not_active Expired - Lifetime
- 2000-03-24 BR BR0010655-0A patent/BR0010655A/pt not_active Application Discontinuation
- 2000-03-24 AP APAP/P/2001/002269A patent/AP1654A/en active
- 2000-03-24 AT AT00913979T patent/ATE327988T1/de not_active IP Right Cessation
- 2000-03-24 CZ CZ20013421A patent/CZ20013421A3/cs unknown
-
2001
- 2001-09-12 IL IL145401A patent/IL145401A/en unknown
- 2001-09-21 NO NO20014593A patent/NO323703B1/no unknown
-
2002
- 2002-05-15 HK HK02103690.5A patent/HK1043985B/zh not_active IP Right Cessation
-
2006
- 2006-07-27 US US11/494,943 patent/US7629337B2/en not_active Expired - Fee Related
-
2009
- 2009-11-04 US US12/612,488 patent/US20100105915A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3546000A (en) | 2000-10-09 |
ATE327988T1 (de) | 2006-06-15 |
TR200102799T2 (tr) | 2002-07-22 |
WO2000056729A1 (en) | 2000-09-28 |
AP1654A (en) | 2006-09-01 |
NZ514709A (en) | 2003-03-28 |
EP1163238A1 (en) | 2001-12-19 |
HUP0200761A3 (en) | 2003-05-28 |
CN1219780C (zh) | 2005-09-21 |
CN1351601A (zh) | 2002-05-29 |
BR0010655A (pt) | 2002-02-13 |
PL350998A1 (en) | 2003-02-24 |
IL145401A (en) | 2007-07-24 |
DE60028354T2 (de) | 2007-02-08 |
HK1043985B (zh) | 2006-11-24 |
AU775123B2 (en) | 2004-07-15 |
NO323703B1 (no) | 2007-06-25 |
AP2001002269A0 (en) | 2001-09-30 |
US20100105915A1 (en) | 2010-04-29 |
KR100766289B1 (ko) | 2007-10-11 |
US20060264434A1 (en) | 2006-11-23 |
HUP0200761A2 (en) | 2002-06-29 |
KR20010108393A (ko) | 2001-12-07 |
EP1163238B1 (en) | 2006-05-31 |
NO20014593D0 (no) | 2001-09-21 |
JP2003524620A (ja) | 2003-08-19 |
ES2265923T3 (es) | 2007-03-01 |
HK1043985A1 (en) | 2002-10-04 |
US7629337B2 (en) | 2009-12-08 |
CZ20013421A3 (cs) | 2002-03-13 |
IL145401A0 (en) | 2002-06-30 |
DE60028354D1 (de) | 2006-07-06 |
NO20014593L (no) | 2001-10-29 |
CA2368047A1 (en) | 2000-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA01009674A (es) | Compuestos heterociclicos que se unen a receptores de quimiocina. | |
EG24743A (en) | Heterocyclic compounds. | |
GB9929973D0 (en) | Heterocyclic compounds | |
MXPA01013362A (es) | Anticuerpos de humano, anti-alfavbeta3 recombinantes, °cidos nucleicos que codifican a los mismos y metodos de uso. | |
HK1054384A1 (en) | 4-Pyrimidinyl-n-acyl-l-phenylalanines. | |
HK1044337A1 (en) | Amide compounds. | |
ZA200203762B (en) | 4-pyridinyl-IN-acyl-L-phenylalanines. | |
ZA200108968B (en) | New compounds. | |
HUP0004291A3 (en) | Ceramic-molding binder | |
AU141040S (en) | Pipette | |
ZA200110053B (en) | Factor via inhibitors. | |
MXPA02000261A (es) | Aminoindanos novedosos. | |
HK1054382A1 (en) | Substituted pyrroles. | |
TR200001070A3 (tr) | Izosiyanat içeren baglayicilar. | |
ZA200301399B (en) | Chemokine receptor binding heterocyclic compounds. | |
ZA200201714B (en) | Novel compound F-15078. | |
HK1031254A1 (en) | Tachogragh. | |
AU9462801A (en) | Chemokine receptor binding heterocyclic compounds | |
PL359523A1 (en) | Chemokine receptor binding heterocyclic compounds | |
ZA200404589B (en) | Chemokine receptor binding heterocyclic compounds with enhanced efficacy. | |
PL111693U1 (en) | Binding | |
MXPA02005346A (es) | Antigenos de cryptosporidium esporozoito. | |
ZA200203987B (en) | Novel compounds. | |
CA86496S (en) | Binder | |
CA86973S (en) | Binder |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |