MXPA01008736A - Metodos para producir acidos carboxilicos alfa-sustituidos, enantiomericamente puros. - Google Patents
Metodos para producir acidos carboxilicos alfa-sustituidos, enantiomericamente puros.Info
- Publication number
- MXPA01008736A MXPA01008736A MXPA01008736A MXPA01008736A MXPA01008736A MX PA01008736 A MXPA01008736 A MX PA01008736A MX PA01008736 A MXPA01008736 A MX PA01008736A MX PA01008736 A MXPA01008736 A MX PA01008736A MX PA01008736 A MXPA01008736 A MX PA01008736A
- Authority
- MX
- Mexico
- Prior art keywords
- enantiomerically pure
- alpha
- carboxylic acids
- methods
- substituted carboxylic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
- C12Y305/05001—Nitrilase (3.5.5.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
De acuerdo con la presente invencion, se proveen metodos para producir acidos carboxilicos ?-sustituidos, enantiomericamente puros, tales como por ejemplo ?- aminoacidos y acidos a-hidroxi, dicho metodo comprendiendo combinar un aldehido o cetona con un cianuro y una sal amoniaco o amonio o una amina, en presencia de una nitrilasa o un polipeptido que tiene actividad nitrilasa que hidroliza estereo-selectivamente el intermediario amino nitrilo o cianohidrina bajo condiciones suficientes para producir el acido carboxilico.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17360999P | 1999-12-29 | 1999-12-29 | |
US25441400P | 2000-12-07 | 2000-12-07 | |
PCT/US2000/035555 WO2001048175A2 (en) | 1999-12-29 | 2000-12-29 | METHODS FOR PRODUCING ENANTIOMERICALLY PURE α-SUBSTITUTED CARBOXYLIC ACIDS |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA01008736A true MXPA01008736A (es) | 2002-06-21 |
MX291457B MX291457B (es) | 2011-10-28 |
Family
ID=26869344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA01008736 MX291457B (es) | 1999-12-29 | 2000-12-29 | Metodos para producir acidos carboxilicos alfa-sustituidos, enantiomericamente puros. |
Country Status (9)
Country | Link |
---|---|
US (9) | US7300775B2 (es) |
EP (2) | EP2258840A1 (es) |
JP (1) | JP4261799B2 (es) |
AU (1) | AU785076B2 (es) |
CA (2) | CA2718302C (es) |
HK (1) | HK1050216B (es) |
IL (1) | IL145054A0 (es) |
MX (1) | MX291457B (es) |
WO (1) | WO2001048175A2 (es) |
Families Citing this family (17)
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US20040002147A1 (en) * | 1999-12-29 | 2004-01-01 | Desantis Grace | Nitrilases |
US7521216B2 (en) | 1999-12-29 | 2009-04-21 | Verenium Corporation | Nitrilases and methods for making and using them |
US7300775B2 (en) | 1999-12-29 | 2007-11-27 | Verenium Corporation | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents |
US7608445B1 (en) | 1999-12-29 | 2009-10-27 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
EP1578910A4 (en) * | 2001-06-21 | 2008-06-04 | Verenium Corp | NITRILASES |
WO2003106415A2 (en) | 2002-06-13 | 2003-12-24 | Diversa Corporation | Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid |
EP1599584B1 (en) | 2003-02-27 | 2009-07-01 | Basf Se | Modified nitrilases and their use in methods for the production of carboxylic acids |
EP1879567A1 (en) | 2005-04-28 | 2008-01-23 | Pfizer Limited | Amino acid derivatives |
WO2008106662A2 (en) * | 2007-03-01 | 2008-09-04 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
KR101223665B1 (ko) * | 2011-01-26 | 2013-01-17 | 재단법인 경북해양바이오산업연구원 | 나이트릴레이즈 rmn2을 이용한 카르복실산의 제조방법 |
KR101719035B1 (ko) * | 2014-09-19 | 2017-03-23 | 포항공과대학교 산학협력단 | 신규 효소를 사용한 d형 젖산의 제조 |
EP3364958B1 (en) * | 2015-10-23 | 2023-01-04 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
US11530352B2 (en) | 2016-10-03 | 2022-12-20 | Illumina, Inc. | Fluorescent detection of amines and hydrazines and assaying methods thereof |
WO2018156094A1 (en) | 2017-02-24 | 2018-08-30 | Murat Can | Emission reducer fuel saving apparatus |
AU2019360338A1 (en) * | 2018-10-18 | 2021-05-20 | Basf Se | Method for the production of acrylic acid or salts thereof |
US20240002787A1 (en) * | 2022-06-30 | 2024-01-04 | Battelle Savannah River Alliance, Llc | Porous glass-based microbial storage and delivery system |
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US7300775B2 (en) | 1999-12-29 | 2007-11-27 | Verenium Corporation | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents |
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-
2000
- 2000-12-28 US US09/751,299 patent/US7300775B2/en not_active Expired - Fee Related
- 2000-12-29 CA CA2718302A patent/CA2718302C/en not_active Expired - Fee Related
- 2000-12-29 MX MXPA01008736 patent/MX291457B/es active IP Right Grant
- 2000-12-29 EP EP20100177452 patent/EP2258840A1/en not_active Withdrawn
- 2000-12-29 IL IL14505400A patent/IL145054A0/xx unknown
- 2000-12-29 CA CA002365224A patent/CA2365224A1/en not_active Abandoned
- 2000-12-29 AU AU26070/01A patent/AU785076B2/en not_active Ceased
- 2000-12-29 WO PCT/US2000/035555 patent/WO2001048175A2/en active Search and Examination
- 2000-12-29 EP EP00989578.0A patent/EP1242589B1/en not_active Expired - Lifetime
- 2000-12-29 JP JP2001548688A patent/JP4261799B2/ja not_active Expired - Fee Related
-
2003
- 2003-03-18 HK HK03101995.0A patent/HK1050216B/zh not_active IP Right Cessation
-
2007
- 2007-10-08 US US11/868,909 patent/US8034595B2/en not_active Expired - Fee Related
-
2009
- 2009-09-09 US US12/556,528 patent/US7811804B2/en not_active Expired - Fee Related
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2010
- 2010-05-04 US US12/773,317 patent/US8088613B2/en not_active Expired - Fee Related
-
2011
- 2011-09-20 US US13/236,862 patent/US8318471B2/en not_active Expired - Fee Related
- 2011-09-21 US US13/238,227 patent/US8501451B2/en not_active Expired - Fee Related
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2012
- 2012-11-12 US US13/674,216 patent/US8778651B2/en not_active Expired - Fee Related
-
2014
- 2014-06-06 US US14/297,989 patent/US9315792B2/en not_active Expired - Fee Related
-
2016
- 2016-03-08 US US15/064,269 patent/US9828594B2/en not_active Expired - Fee Related
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