MX9801892A - Nitrones ciclicos y composiciones farmaceuticas que los contienen. - Google Patents

Nitrones ciclicos y composiciones farmaceuticas que los contienen.

Info

Publication number
MX9801892A
MX9801892A MX9801892A MX9801892A MX9801892A MX 9801892 A MX9801892 A MX 9801892A MX 9801892 A MX9801892 A MX 9801892A MX 9801892 A MX9801892 A MX 9801892A MX 9801892 A MX9801892 A MX 9801892A
Authority
MX
Mexico
Prior art keywords
ring
alkyl
hydrogen
group
represented
Prior art date
Application number
MX9801892A
Other languages
English (en)
Inventor
Craig E Thomas
Thomas L Fevig
Stephen M Bowen
Robert A Farr
Albert A Carr
David A Janowick
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of MX9801892A publication Critical patent/MX9801892A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion está dirigida a nitrones cíclicos novedosos de la formula (I), en la cual R1 y R2 está cada uno independientemente representado por alquilo de C1-3, o R1 y R2 juntos forman un anillo de alquileno de C5-6 o un anillo de la estructura (a), Z representa (CHx)n, en donde x y n son independientemente 0 o un entero de 1-2; R3 está representado por un substituyente seleccionado del grupo que consiste de hidrogeno, alquilo de C1-4, OH, OAc o (b); y el anillo representado por X es un substituyente seleccionado del grupo que consiste de (c), (d), (e) o (f), en donde el área de sombra obscura representa el lado de union al anillo de nitrogeno, R4, R5, R6 y R7 se seleccionan independientemente del grupo que consiste de hidrogeno, alquilo de C1-3, OH, o alcoxi de C1-3, y sus sales farmacéuticamente aceptables, siempre que cuando R1 y R2 juntos formen un anillo alquileno de C5-6 y n sea 1, entonces R3 no puede ser hidrogeno, y su uso en la prevencion de daño de tejido oxidante a través de radicales libres, su uso en el tratamiento de un numero de estados de enfermedad, en donde los radicales tanto dañan como destruyen los tejidos vía oxidacion, y composiciones farmacéuticas que contienen estos nitrones cíclicos.
MX9801892A 1995-09-11 1996-08-15 Nitrones ciclicos y composiciones farmaceuticas que los contienen. MX9801892A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US355195P 1995-09-11 1995-09-11
PCT/US1996/013312 WO1997010218A1 (en) 1995-09-11 1996-08-15 Cyclic nitrones and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9801892A true MX9801892A (es) 1998-05-31

Family

ID=21706397

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9801892A MX9801892A (es) 1995-09-11 1996-08-15 Nitrones ciclicos y composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
US (1) US5962469A (es)
EP (1) EP0863878B1 (es)
JP (1) JPH11512427A (es)
KR (1) KR100512675B1 (es)
CN (3) CN1500787A (es)
AR (1) AR004950A1 (es)
AT (2) ATE293604T1 (es)
AU (1) AU701989B2 (es)
CA (1) CA2231812C (es)
DE (2) DE69634647T2 (es)
DK (2) DK0863878T3 (es)
ES (2) ES2185797T3 (es)
HU (1) HUP9803028A3 (es)
IL (1) IL123345A (es)
MX (1) MX9801892A (es)
NO (1) NO311357B1 (es)
NZ (1) NZ316288A (es)
PT (2) PT863878E (es)
TW (1) TW337520B (es)
WO (1) WO1997010218A1 (es)
ZA (1) ZA967514B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015831A (en) * 1998-01-16 2000-01-18 Centaur Pharmaceuticals, Inc. Thiophene nitrone compounds
EP1147113B1 (en) * 1999-01-19 2006-06-07 Neurosearch A/S Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases
CN100513395C (zh) * 2006-04-17 2009-07-15 中国科学院化学研究所 一种制备多羟基环状硝酮的方法
CN101565453B (zh) * 2008-04-22 2011-12-21 中国科学院化学研究所 具有捕获自由基功能的硝酮类化合物及其制备方法与应用
ES2395803B1 (es) * 2011-08-01 2013-12-19 Consejo Superior De Investigaciones Científicas (Csic) - 80% Quinolilnitronas
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
US10660851B2 (en) 2015-01-02 2020-05-26 Rxos Medical Polyfunctional radical scavenger hydrogel formulation
CN108774274B (zh) * 2015-03-06 2020-11-03 北京大学 唾液酸甲酯甲苷衍生物及其合成方法和应用
ES2799705T3 (es) 2016-02-08 2020-12-21 Lunaphore Tech Sa Procedimientos de multiplexación cíclica de muestras y obtención de imágenes in situ

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35112A (en) * 1862-04-29 Improvement in head-rests for car-seats
US3044930A (en) * 1960-12-08 1962-07-17 Phillips Petroleum Co N-oxides of heterocyclic nitrogen compounds as bird and rodent repellents
US3796715A (en) * 1967-08-30 1974-03-12 Hoffmann La Roche 8-alkoxy-3,4-dihydroisoquinolines
SE368009B (es) * 1971-09-16 1974-06-17 Kabi Ab
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system
US4117144A (en) * 1971-09-16 1978-09-26 Ab Kabi Derivatives of substituted isoindolines with effect on the central nervous system
JPS6363851A (ja) * 1986-09-05 1988-03-22 孫七瓦工業株式会社 瓦の葺設方法
CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
EP0590072B1 (en) * 1991-06-18 2001-12-05 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
AU652662B2 (en) * 1991-09-12 1994-09-01 Aventis Inc. Cyclic nitrones
US5405967A (en) * 1993-10-22 1995-04-11 Oklahoma Medical Research Foundation Spin-trap molecules 2-trifluoromethyl- of 5,5-dimethyl-1-dyrroline-N-oxide
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
EP0675892A1 (en) * 1993-10-25 1995-10-11 Oklahoma Medical Research Foundation Novel phosphorus-containing spin-trap compositions
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions

Also Published As

Publication number Publication date
ES2185797T3 (es) 2003-05-01
DE69625701D1 (de) 2003-02-13
IL123345A0 (en) 1998-09-24
NO981054D0 (no) 1998-03-10
TW337520B (en) 1998-08-01
ATE230731T1 (de) 2003-01-15
ZA967514B (en) 1997-03-10
CN1500787A (zh) 2004-06-02
KR19990044557A (ko) 1999-06-25
ATE293604T1 (de) 2005-05-15
HUP9803028A3 (en) 1999-05-28
AU6848696A (en) 1997-04-01
PT1288203E (pt) 2005-08-31
HUP9803028A2 (hu) 1999-04-28
NO981054L (no) 1998-03-10
AR004950A1 (es) 1999-04-07
IL123345A (en) 2003-07-31
KR100512675B1 (ko) 2006-08-10
WO1997010218A1 (en) 1997-03-20
US5962469A (en) 1999-10-05
CN1500779A (zh) 2004-06-02
JPH11512427A (ja) 1999-10-26
CA2231812A1 (en) 1997-03-20
DK0863878T3 (da) 2003-04-22
EP0863878A1 (en) 1998-09-16
EP0863878B1 (en) 2003-01-08
DE69634647T2 (de) 2006-03-02
ES2239194T3 (es) 2005-09-16
AU701989B2 (en) 1999-02-11
CN1196050A (zh) 1998-10-14
DK1288203T3 (da) 2005-07-11
NO311357B1 (no) 2001-11-19
DE69634647D1 (de) 2005-05-25
DE69625701T2 (de) 2003-10-02
CN1250528C (zh) 2006-04-12
NZ316288A (en) 2000-01-28
CA2231812C (en) 2002-08-06
PT863878E (pt) 2003-04-30

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: ARVINMERITOR, INC.

MM Annulment or lapse due to non-payment of fees