TW337520B - Cyclic nitrones - Google Patents

Cyclic nitrones

Info

Publication number
TW337520B
TW337520B TW085110921A TW85110921A TW337520B TW 337520 B TW337520 B TW 337520B TW 085110921 A TW085110921 A TW 085110921A TW 85110921 A TW85110921 A TW 85110921A TW 337520 B TW337520 B TW 337520B
Authority
TW
Taiwan
Prior art keywords
chain
following
hydrogen
expanded
alkyl
Prior art date
Application number
TW085110921A
Other languages
English (en)
Inventor
Craig E Thomas
Thomas L Fevig
David A Janowick
Stephen M Bowen
Robert A Farr
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of TW337520B publication Critical patent/TW337520B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW085110921A 1995-09-11 1996-09-06 Cyclic nitrones TW337520B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US355195P 1995-09-11 1995-09-11

Publications (1)

Publication Number Publication Date
TW337520B true TW337520B (en) 1998-08-01

Family

ID=21706397

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085110921A TW337520B (en) 1995-09-11 1996-09-06 Cyclic nitrones

Country Status (21)

Country Link
US (1) US5962469A (zh)
EP (1) EP0863878B1 (zh)
JP (1) JPH11512427A (zh)
KR (1) KR100512675B1 (zh)
CN (3) CN1250528C (zh)
AR (1) AR004950A1 (zh)
AT (2) ATE293604T1 (zh)
AU (1) AU701989B2 (zh)
CA (1) CA2231812C (zh)
DE (2) DE69625701T2 (zh)
DK (2) DK0863878T3 (zh)
ES (2) ES2185797T3 (zh)
HU (1) HUP9803028A3 (zh)
IL (1) IL123345A (zh)
MX (1) MX9801892A (zh)
NO (1) NO311357B1 (zh)
NZ (1) NZ316288A (zh)
PT (2) PT1288203E (zh)
TW (1) TW337520B (zh)
WO (1) WO1997010218A1 (zh)
ZA (1) ZA967514B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2226999A (en) * 1998-01-16 1999-08-02 Renovis, Inc. Thiophene nitrone compounds
CN1147490C (zh) * 1999-01-19 2004-04-28 神经研究公司 呋喃并四吡啶衍生物及其药物组合物和用于治疗神经变形疾病的用途
CN100513395C (zh) * 2006-04-17 2009-07-15 中国科学院化学研究所 一种制备多羟基环状硝酮的方法
CN101565453B (zh) * 2008-04-22 2011-12-21 中国科学院化学研究所 具有捕获自由基功能的硝酮类化合物及其制备方法与应用
ES2395803B1 (es) * 2011-08-01 2013-12-19 Consejo Superior De Investigaciones Científicas (Csic) - 80% Quinolilnitronas
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
US10660851B2 (en) 2015-01-02 2020-05-26 Rxos Medical Polyfunctional radical scavenger hydrogel formulation
CN108774274B (zh) * 2015-03-06 2020-11-03 北京大学 唾液酸甲酯甲苷衍生物及其合成方法和应用
JP7033081B2 (ja) * 2016-02-08 2022-03-09 ルナフォア・テクノロジーズ・エスアー 試料サイクル多重化及びインサイツイメージングの方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35112A (en) * 1862-04-29 Improvement in head-rests for car-seats
US3044930A (en) * 1960-12-08 1962-07-17 Phillips Petroleum Co N-oxides of heterocyclic nitrogen compounds as bird and rodent repellents
US3796715A (en) * 1967-08-30 1974-03-12 Hoffmann La Roche 8-alkoxy-3,4-dihydroisoquinolines
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system
SE368009B (zh) * 1971-09-16 1974-06-17 Kabi Ab
US4117144A (en) * 1971-09-16 1978-09-26 Ab Kabi Derivatives of substituted isoindolines with effect on the central nervous system
JPS6363851A (ja) * 1986-09-05 1988-03-22 孫七瓦工業株式会社 瓦の葺設方法
ES2044829T3 (es) * 1989-10-17 1995-01-16 Oklahoma Med Res Found Metodo y composiciones para la inhibicion de alteraciones asociadas con las lesiones oxidativas de los tejidos.
WO1992022290A1 (en) * 1991-06-18 1992-12-23 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
TW257755B (zh) * 1991-09-12 1995-09-21 Merrell Dow Pharma
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5405967A (en) * 1993-10-22 1995-04-11 Oklahoma Medical Research Foundation Spin-trap molecules 2-trifluoromethyl- of 5,5-dimethyl-1-dyrroline-N-oxide
AU8051894A (en) * 1993-10-25 1995-05-22 Oklahoma Medical Research Foundation Novel phosphorus-containing spin-trap compositions
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions

Also Published As

Publication number Publication date
IL123345A (en) 2003-07-31
CA2231812C (en) 2002-08-06
CA2231812A1 (en) 1997-03-20
WO1997010218A1 (en) 1997-03-20
IL123345A0 (en) 1998-09-24
US5962469A (en) 1999-10-05
KR19990044557A (ko) 1999-06-25
JPH11512427A (ja) 1999-10-26
DE69625701T2 (de) 2003-10-02
DK0863878T3 (da) 2003-04-22
ZA967514B (en) 1997-03-10
EP0863878A1 (en) 1998-09-16
DE69625701D1 (de) 2003-02-13
DE69634647T2 (de) 2006-03-02
AU701989B2 (en) 1999-02-11
CN1250528C (zh) 2006-04-12
PT1288203E (pt) 2005-08-31
MX9801892A (es) 1998-05-31
NO981054L (no) 1998-03-10
EP0863878B1 (en) 2003-01-08
NO981054D0 (no) 1998-03-10
ATE293604T1 (de) 2005-05-15
NZ316288A (en) 2000-01-28
AU6848696A (en) 1997-04-01
CN1196050A (zh) 1998-10-14
HUP9803028A3 (en) 1999-05-28
DK1288203T3 (da) 2005-07-11
DE69634647D1 (de) 2005-05-25
HUP9803028A2 (hu) 1999-04-28
ES2239194T3 (es) 2005-09-16
ES2185797T3 (es) 2003-05-01
CN1500787A (zh) 2004-06-02
NO311357B1 (no) 2001-11-19
KR100512675B1 (ko) 2006-08-10
AR004950A1 (es) 1999-04-07
PT863878E (pt) 2003-04-30
ATE230731T1 (de) 2003-01-15
CN1500779A (zh) 2004-06-02

Similar Documents

Publication Publication Date Title
EP0669324A4 (en) CHINAZOLIN DERIVATIVES.
NL300374I2 (nl) Een pyrrolidythiocarbapenemderivaat met antibacteriële
GB0007405D0 (en) Compounds
MY114655A (en) Indolopyrrolocarbazole derivatives
TW328089B (en) New azolidinediones as antihyperglycemic agents
CA2161499A1 (en) Synergistic stabiliser mixture
MX9606331A (es) Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor.
EP0870771A4 (en) SUGAR COMPOUNDS
TW337520B (en) Cyclic nitrones
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
TW258735B (zh)
CA2087859A1 (en) Benzopyran derivatives
TW334425B (en) Annelated dihydropyridines for preparing pharmaceutical preparations
TW350041B (en) Bis-depside tertiary alkyl ester derivatives and chemical positive photoresist material
TW328957B (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
EP1020459A4 (en) CIS DISUBSTITUTED AMINOCYCLOALKYL PYRROLIDINE DERIVATIVES
EP0601191A4 (en) Novel tetracyclic compound.
TW328945B (en) Carbamoylcarboxamides
FI964278A0 (fi) Menetelmä 5,6-dihydroksi-2-amino-1,2,3,4-tetrahydronaftaleenin johdannaisten valmistamiseksi
EP0794178A4 (en) CHINAZOLIN DERIVATIVES
TW329388B (en) Intraocular irrigating solution
PL342992A1 (en) New compounds
EP0657412A4 (zh)
MX9603450A (es) Procedimiento para la obtencion de aminotriazolinas substituidas.
MX9500251A (es) Derivado de indano, procedimiento para prepararlo.