MX9801516A - Compuestos de 7 anillos condensados, sustituidos con sulfonamida, su empleo como medicamento asi como preparados que los contienen. - Google Patents

Compuestos de 7 anillos condensados, sustituidos con sulfonamida, su empleo como medicamento asi como preparados que los contienen.

Info

Publication number
MX9801516A
MX9801516A MX9801516A MX9801516A MX9801516A MX 9801516 A MX9801516 A MX 9801516A MX 9801516 A MX9801516 A MX 9801516A MX 9801516 A MX9801516 A MX 9801516A MX 9801516 A MX9801516 A MX 9801516A
Authority
MX
Mexico
Prior art keywords
alkyl
nme2
halo
nhso2me
so2me
Prior art date
Application number
MX9801516A
Other languages
English (en)
Inventor
Joachim Brendel
Hans Jochen Lang
Uwe Gerlach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9801516A publication Critical patent/MX9801516A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

La presente invencion se refiere a compuestos de la formula I en donde X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4), y R(5) tienen los significados indicados en las reivindicaciones, a su preparacion y a su empleo, en particular en medicamentos. Los compuestos influyen sobre el canal de potasio o el canal de Iks abierto por adenosina monofosfato cíclico (AMPc) y se adecuan de manera extraordinaria como principios activos medicamentosos, por ejemplo para la profilaxis y terapia de enfermedades circulatorias del corazon, en particular de arritmias, para el tratamiento de ulceras del tramo gastrointestinal o para el tratamiento de enfermedades diarreícas.
MX9801516A 1997-02-26 1998-02-25 Compuestos de 7 anillos condensados, sustituidos con sulfonamida, su empleo como medicamento asi como preparados que los contienen. MX9801516A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19707656A DE19707656A1 (de) 1997-02-26 1997-02-26 Sulfonamid-substituierte anellierte 7-Ring-Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
MX9801516A true MX9801516A (es) 1998-11-30

Family

ID=7821518

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9801516A MX9801516A (es) 1997-02-26 1998-02-25 Compuestos de 7 anillos condensados, sustituidos con sulfonamida, su empleo como medicamento asi como preparados que los contienen.

Country Status (25)

Country Link
EP (1) EP0861836B1 (es)
JP (1) JP4171097B2 (es)
KR (1) KR19980071625A (es)
CN (1) CN1110490C (es)
AR (1) AR011163A1 (es)
AT (1) ATE286039T1 (es)
AU (1) AU737461B2 (es)
BR (1) BR9800207A (es)
CA (1) CA2230349A1 (es)
CZ (1) CZ53998A3 (es)
DE (2) DE19707656A1 (es)
ES (1) ES2234044T3 (es)
HR (1) HRP980098A2 (es)
HU (1) HUP9800395A3 (es)
ID (1) ID19931A (es)
IL (1) IL123454A0 (es)
MX (1) MX9801516A (es)
NO (1) NO980785L (es)
NZ (1) NZ329838A (es)
PL (1) PL325045A1 (es)
RU (1) RU2223264C2 (es)
SK (1) SK283312B6 (es)
TR (1) TR199800301A2 (es)
TW (1) TW452574B (es)
ZA (1) ZA981562B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858253A1 (de) 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
DE19929076A1 (de) * 1999-06-25 2000-12-28 Aventis Pharma Gmbh Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7384937B2 (en) 2002-11-06 2008-06-10 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
US20120309796A1 (en) * 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
RU2538962C1 (ru) * 2013-11-19 2015-01-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Противогрибковые соединения на основе производных 3,5,8-триоксабицикло[5.1.0]октана

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
GB9225860D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment

Also Published As

Publication number Publication date
HU9800395D0 (en) 1998-04-28
RU2223264C2 (ru) 2004-02-10
DE19707656A1 (de) 1998-08-27
HRP980098A2 (en) 1998-12-31
SK23998A3 (en) 1998-09-09
KR19980071625A (ko) 1998-10-26
EP0861836B1 (de) 2004-12-29
HUP9800395A2 (hu) 2001-04-28
ID19931A (id) 1998-08-27
PL325045A1 (en) 1998-08-31
DE59812423D1 (de) 2005-02-03
AU737461B2 (en) 2001-08-23
CN1110490C (zh) 2003-06-04
AR011163A1 (es) 2000-08-02
TW452574B (en) 2001-09-01
AU5633398A (en) 1998-09-03
IL123454A0 (en) 1998-09-24
HUP9800395A3 (en) 2002-04-29
BR9800207A (pt) 1999-05-18
ES2234044T3 (es) 2005-06-16
NO980785D0 (no) 1998-02-25
EP0861836A1 (de) 1998-09-02
TR199800301A2 (xx) 1998-09-21
NZ329838A (en) 1999-07-29
NO980785L (no) 1998-08-27
ZA981562B (en) 1998-08-26
CN1193017A (zh) 1998-09-16
SK283312B6 (sk) 2003-05-02
JPH10287641A (ja) 1998-10-27
ATE286039T1 (de) 2005-01-15
CZ53998A3 (cs) 1998-09-16
CA2230349A1 (en) 1998-08-26
JP4171097B2 (ja) 2008-10-22

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees