MX9801428A - Compuestos esteroidales que tiene actividad anticonceptiva y anti-osteoporosis. - Google Patents

Compuestos esteroidales que tiene actividad anticonceptiva y anti-osteoporosis.

Info

Publication number
MX9801428A
MX9801428A MX9801428A MX9801428A MX9801428A MX 9801428 A MX9801428 A MX 9801428A MX 9801428 A MX9801428 A MX 9801428A MX 9801428 A MX9801428 A MX 9801428A MX 9801428 A MX9801428 A MX 9801428A
Authority
MX
Mexico
Prior art keywords
ring
steroid compounds
contraceptive
steroid
prevention
Prior art date
Application number
MX9801428A
Other languages
English (en)
Other versions
MXPA98001428A (es
Inventor
H J J Loozen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MX9801428A publication Critical patent/MX9801428A/es
Publication of MXPA98001428A publication Critical patent/MXPA98001428A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a un compuesto esteroidal que tiene la formula (I), que comprende un anillo E, dicho anillo compartiendo átomos de carbono en la posicion 16 y 17 con el anillo D de cinco miembros y siendo alfa con respecto a dicho anillo D. Además, el átomo de carbono en la posicion 17 está substituido con un grupo que comprende un átomo de oxígeno a través de un enlace de CO. La invencion también se refiere a una composicion farmacéutica que comprende dicho compuesto esteroidal. Los compuestos esteroidales de la presente invencion son muy adecuados para usarse en la prevencion o el tratamiento de quejas peri-menopáusicas o menopáusicas, muy preferiblemente para la prevencion o el tratamiento de osteoporosis. Además los compuestos esteroidales de la presente invencion pueden ser usados para propositos anticonceptivos.
MXPA/A/1998/001428A 1997-02-21 1998-02-20 Compuestos esteroidales que tienen actividad anticonceptiva y anti-osteoporosis MXPA98001428A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97102884 1997-02-21
EP97102884.0 1997-02-21

Publications (2)

Publication Number Publication Date
MX9801428A true MX9801428A (es) 1998-12-31
MXPA98001428A MXPA98001428A (es) 1999-02-01

Family

ID=

Also Published As

Publication number Publication date
RU2182153C2 (ru) 2002-05-10
JPH10273499A (ja) 1998-10-13
PT869132E (pt) 2002-01-30
NO310724B1 (no) 2001-08-20
ZA981344B (en) 1998-08-27
NO980737L (no) 1998-08-24
PL188079B1 (pl) 2004-12-31
HUP9800373A2 (hu) 1998-11-30
EP0869132A1 (en) 1998-10-07
ES2164400T3 (es) 2002-02-16
TW403736B (en) 2000-09-01
IL123195A (en) 2002-11-10
SG60203A1 (en) 1999-02-22
CN1197076A (zh) 1998-10-28
NZ329789A (en) 1999-09-29
US6077873A (en) 2000-06-20
AU723713B2 (en) 2000-09-07
AU5541298A (en) 1998-08-27
DE69801539D1 (de) 2001-10-11
CN101092442A (zh) 2007-12-26
HU9800373D0 (en) 1998-04-28
ATE205217T1 (de) 2001-09-15
DE69801539T2 (de) 2002-04-18
HU223755B1 (hu) 2005-01-28
CA2229960A1 (en) 1998-08-21
EP0869132B1 (en) 2001-09-05
HK1016188A1 (en) 1999-10-29
PL324939A1 (en) 1998-08-31
ID19947A (id) 1998-08-27
AR011680A1 (es) 2000-08-30
CN100522984C (zh) 2009-08-05
BR9800718B1 (pt) 2009-08-11
US6313180B1 (en) 2001-11-06
BR9800718A (pt) 1999-06-29
NO980737D0 (no) 1998-02-20
JP4392066B2 (ja) 2009-12-24
KR19980071540A (ko) 1998-10-26
IL123195A0 (en) 1998-09-24
HUP9800373A3 (en) 1999-06-28
TR199800282A1 (xx) 1998-09-21
CA2229960C (en) 2007-12-18
CZ50598A3 (cs) 1998-09-16
DK0869132T3 (da) 2002-01-07

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: N.V. ORGANON.*

MM Annulment or lapse due to non-payment of fees