MX9700210A - Nuevas sales de acido 2-((2,6-diclorofenil) amina)fenilacetoxiacetico con cationes basicos organicos. - Google Patents

Nuevas sales de acido 2-((2,6-diclorofenil) amina)fenilacetoxiacetico con cationes basicos organicos.

Info

Publication number
MX9700210A
MX9700210A MX9700210A MX9700210A MX9700210A MX 9700210 A MX9700210 A MX 9700210A MX 9700210 A MX9700210 A MX 9700210A MX 9700210 A MX9700210 A MX 9700210A MX 9700210 A MX9700210 A MX 9700210A
Authority
MX
Mexico
Prior art keywords
dichlorophenyl
amine
organic basic
phenylacetoxyacetic acid
new salts
Prior art date
Application number
MX9700210A
Other languages
English (en)
Other versions
MXPA97000210A (es
Inventor
Alfred Sallmann
Original Assignee
Novartis Ag Tambien Denominada
Y O Novartis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Tambien Denominada, Y O Novartis Inc filed Critical Novartis Ag Tambien Denominada
Publication of MXPA97000210A publication Critical patent/MXPA97000210A/es
Publication of MX9700210A publication Critical patent/MX9700210A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/05—Mono-, di- or tri-ethylamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una sal de ácido 2-[(2,6-diclorofenil)amina] fenilacetoxiacético con un cation básico orgánico de la formula (Ver Formula) en donde R1 y R2 son independientemente alquilo inferior, o si R1 es hidrogeno H-N(R1)(R2) tiene el significado de arginina o lisina, o si R1 es metilo, H-N(R1)(R2) tiene el significado de glucamina N-metilica. Este compuesto posee actividad analgésica, así como actividad anti-inflamatoria, es adecuado en el tratamiento de condiciones tales como artritis reumatoide, espondilitis anquilosante, dolores lumbares, luxaciones, e inflamacion ocular. El compuesto tiene además una mejor estabilidad en soluciones acuosas en comparacion con las sales de metal alcalino, por ejemplo, sodio y potasio.
MX9700210A 1994-06-29 1995-06-28 Nuevas sales de acido 2-((2,6-diclorofenil) amina)fenilacetoxiacetico con cationes basicos organicos. MX9700210A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94810382.5 1994-06-29
EP94810382 1994-06-29
PCT/IB1995/000524 WO1996000716A1 (en) 1994-06-29 1995-06-28 New salts of 2-[(2,6-dichlorophenyl)amine]phenylacetoxyacetic acid with organic basic cations

Publications (2)

Publication Number Publication Date
MXPA97000210A MXPA97000210A (es) 1998-01-01
MX9700210A true MX9700210A (es) 1998-01-31

Family

ID=8218277

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700210A MX9700210A (es) 1994-06-29 1995-06-28 Nuevas sales de acido 2-((2,6-diclorofenil) amina)fenilacetoxiacetico con cationes basicos organicos.

Country Status (17)

Country Link
US (1) US5708024A (es)
EP (1) EP0767777B1 (es)
JP (1) JPH11505503A (es)
AT (1) ATE178884T1 (es)
AU (1) AU2628895A (es)
CA (1) CA2192682A1 (es)
CZ (1) CZ380596A3 (es)
DE (1) DE69509091T2 (es)
DK (1) DK0767777T3 (es)
ES (1) ES2132672T3 (es)
FI (1) FI965157A0 (es)
GR (1) GR3030625T3 (es)
HU (1) HUT75341A (es)
MX (1) MX9700210A (es)
NO (1) NO965505D0 (es)
PL (1) PL318014A1 (es)
WO (1) WO1996000716A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
GB0007239D0 (en) * 2000-03-24 2000-05-17 Nycomed Imaging As Use
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
KR100749162B1 (ko) 2005-10-24 2007-08-14 주식회사 엔지켐 아세클로페낙 아미노산염의 제조방법
CN105213010A (zh) 2008-01-14 2016-01-06 康文图斯整形外科公司 用于骨折修补的装置和方法
RU2012122654A (ru) * 2009-11-05 2013-12-10 Алкем Лабораториз Лтд. Стабильная фармацевтическая инъекционная композиция ацеклофенака и способ ее получения

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT368129B (de) * 1980-06-03 1982-09-10 Gerot Pharmazeutika Verfahren zur herstellung neuer salze von o-(2,6- dichloranilino)-phenylessigsaeure
AT370721B (de) * 1981-02-24 1983-04-25 Ciba Geigy Ag Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
CH651821A5 (en) * 1981-02-18 1985-10-15 Ciba Geigy Ag Salts of a phenylacetic acid, and a process for their preparation
ES520813A0 (es) * 1983-03-21 1984-05-16 Prodes Sa Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico.
IT1228242B (it) * 1986-11-13 1991-06-05 Ricerfarma Srl Milano Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono
IT1250636B (it) * 1991-07-04 1995-04-21 Ricerche Di Schiena Del Dr Mic Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono.

Also Published As

Publication number Publication date
AU2628895A (en) 1996-01-25
DE69509091T2 (de) 1999-09-09
FI965157A (fi) 1996-12-20
CZ380596A3 (en) 1997-08-13
JPH11505503A (ja) 1999-05-21
US5708024A (en) 1998-01-13
WO1996000716A1 (en) 1996-01-11
DK0767777T3 (da) 1999-10-25
ES2132672T3 (es) 1999-08-16
CA2192682A1 (en) 1996-01-11
ATE178884T1 (de) 1999-04-15
FI965157A0 (fi) 1996-12-20
EP0767777A1 (en) 1997-04-16
DE69509091D1 (de) 1999-05-20
NO965505L (no) 1996-12-20
PL318014A1 (en) 1997-05-12
GR3030625T3 (en) 1999-10-29
EP0767777B1 (en) 1999-04-14
HUT75341A (en) 1997-05-28
NO965505D0 (no) 1996-12-20
HU9603590D0 (en) 1997-02-28

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