MX9306528A - Derivados de sulfonamida de compuestos anulares de cicloalquilo-heterociclico substituidos con hidroxi, de benceno fundido. - Google Patents
Derivados de sulfonamida de compuestos anulares de cicloalquilo-heterociclico substituidos con hidroxi, de benceno fundido.Info
- Publication number
- MX9306528A MX9306528A MX9306528A MX9306528A MX9306528A MX 9306528 A MX9306528 A MX 9306528A MX 9306528 A MX9306528 A MX 9306528A MX 9306528 A MX9306528 A MX 9306528A MX 9306528 A MX9306528 A MX 9306528A
- Authority
- MX
- Mexico
- Prior art keywords
- hetero
- cycloalkyl
- hydroxy
- annular
- cyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos de la fórmula I, y sus sales y profármacos farmacéuticamente aceptables; en donde X1, Ar, X, Y1, R1, R2, R3, R5, y n son como se define más adelante, que son inhibidores de la producción de leucotrienos y/o bloqueadores de receptores de leucotrieno; métodos para preparar dichos compuestos e intermediarios útiles en su preparación; sus composiciones farmacéuticas, y métodos de tratamiento con ellas. Los compuestos de la fórmula anterior son útiles en la prevención o tratamiento de asma, artritis, psoriasis, úlceras, infartos al miocardio y enfermedades relacionadas, en mamíferos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96433792A | 1992-10-21 | 1992-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9306528A true MX9306528A (es) | 1994-06-30 |
Family
ID=25508435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9306528A MX9306528A (es) | 1992-10-21 | 1993-10-20 | Derivados de sulfonamida de compuestos anulares de cicloalquilo-heterociclico substituidos con hidroxi, de benceno fundido. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5641789A (es) |
EP (1) | EP0665842A1 (es) |
JP (1) | JPH07508534A (es) |
KR (1) | KR950704309A (es) |
CN (1) | CN1090282A (es) |
AP (1) | AP9300578A0 (es) |
AU (1) | AU5536794A (es) |
BR (1) | BR9307277A (es) |
CA (1) | CA2146261A1 (es) |
CZ (1) | CZ100095A3 (es) |
FI (1) | FI934625A (es) |
HR (1) | HRP931297A2 (es) |
HU (1) | HUT68323A (es) |
IL (1) | IL107294A0 (es) |
MA (1) | MA23009A1 (es) |
MX (1) | MX9306528A (es) |
NO (1) | NO303224B1 (es) |
PL (1) | PL308474A1 (es) |
RU (1) | RU95109929A (es) |
SI (1) | SI9300554A (es) |
TW (1) | TW265335B (es) |
WO (1) | WO1994008996A1 (es) |
ZA (1) | ZA937782B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5539128A (en) * | 1994-11-30 | 1996-07-23 | Pfizer Inc. | Processes and intermediates for preparing cis(+)3-[4,6-dihydroxy chroman-3-ylmethyl]-4-methoxyaniline |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
AU713701B2 (en) * | 1996-09-16 | 1999-12-09 | Pfizer Inc. | Processes and intermediates for preparing substituted chromanol derivatives |
ZA981080B (en) | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
GB9800039D0 (en) * | 1998-01-02 | 1998-03-04 | Univ Cardiff | Benzyl and benzylidene tetralins and derivatives |
RU2182004C1 (ru) * | 2001-02-22 | 2002-05-10 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Лекарственный препарат для парентерального применения |
CN100516059C (zh) * | 2001-04-10 | 2009-07-22 | 宝生物工程株式会社 | 治疗剂 |
US7851486B2 (en) * | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
US7507531B2 (en) * | 2002-10-17 | 2009-03-24 | Decode Genetics Chf. | Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
AU2003301305A1 (en) * | 2002-10-17 | 2004-05-04 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
CA2539276A1 (en) * | 2003-09-17 | 2005-03-31 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
US20060210514A1 (en) * | 2005-03-18 | 2006-09-21 | Mower Thomas E | Skin protection and moisturizing compositions and method of making the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059609A (en) * | 1987-10-19 | 1991-10-22 | Pfizer Inc. | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
WO1990015801A1 (en) * | 1989-06-22 | 1990-12-27 | Pfizer Inc. | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases |
-
1993
- 1993-09-30 AU AU55367/94A patent/AU5536794A/en not_active Abandoned
- 1993-09-30 PL PL93308474A patent/PL308474A1/xx unknown
- 1993-09-30 EP EP94900348A patent/EP0665842A1/en not_active Ceased
- 1993-09-30 BR BR9307277A patent/BR9307277A/pt not_active Application Discontinuation
- 1993-09-30 US US08/416,681 patent/US5641789A/en not_active Expired - Fee Related
- 1993-09-30 KR KR1019950701525A patent/KR950704309A/ko not_active Application Discontinuation
- 1993-09-30 WO PCT/US1993/009171 patent/WO1994008996A1/en not_active Application Discontinuation
- 1993-09-30 CZ CZ951000A patent/CZ100095A3/cs unknown
- 1993-09-30 CA CA002146261A patent/CA2146261A1/en not_active Abandoned
- 1993-09-30 JP JP6510027A patent/JPH07508534A/ja active Pending
- 1993-09-30 RU RU95109929/04A patent/RU95109929A/ru unknown
- 1993-10-06 TW TW082108282A patent/TW265335B/zh active
- 1993-10-07 AP APAP/P/1993/000578A patent/AP9300578A0/en unknown
- 1993-10-14 IL IL107294A patent/IL107294A0/xx unknown
- 1993-10-18 HR HR07/964,337A patent/HRP931297A2/xx not_active Application Discontinuation
- 1993-10-20 CN CN93119221A patent/CN1090282A/zh active Pending
- 1993-10-20 MA MA23314A patent/MA23009A1/fr unknown
- 1993-10-20 SI SI9300554A patent/SI9300554A/sl unknown
- 1993-10-20 FI FI934625A patent/FI934625A/fi not_active Application Discontinuation
- 1993-10-20 ZA ZA937782A patent/ZA937782B/xx unknown
- 1993-10-20 MX MX9306528A patent/MX9306528A/es unknown
- 1993-10-20 HU HU9302969A patent/HUT68323A/hu unknown
-
1995
- 1995-04-20 NO NO951506A patent/NO303224B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI934625A0 (fi) | 1993-10-20 |
US5641789A (en) | 1997-06-24 |
CN1090282A (zh) | 1994-08-03 |
HUT68323A (en) | 1995-06-28 |
NO951506D0 (no) | 1995-04-20 |
FI934625A (fi) | 1994-04-22 |
AP9300578A0 (en) | 1995-04-07 |
KR950704309A (ko) | 1995-11-17 |
AU5536794A (en) | 1994-05-09 |
ZA937782B (en) | 1995-04-20 |
CZ100095A3 (en) | 1995-11-15 |
SI9300554A (en) | 1995-04-30 |
HU9302969D0 (en) | 1993-12-28 |
WO1994008996A1 (en) | 1994-04-28 |
NO951506L (no) | 1995-04-20 |
NO303224B1 (no) | 1998-06-15 |
EP0665842A1 (en) | 1995-08-09 |
PL308474A1 (en) | 1995-08-07 |
JPH07508534A (ja) | 1995-09-21 |
IL107294A0 (en) | 1994-01-25 |
BR9307277A (pt) | 1999-05-11 |
CA2146261A1 (en) | 1994-04-28 |
MA23009A1 (fr) | 1994-07-01 |
HRP931297A2 (en) | 1996-08-31 |
RU95109929A (ru) | 1997-03-20 |
TW265335B (es) | 1995-12-11 |
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