MX9304719A - Proceso para la cristalizacion de aspartama. - Google Patents

Proceso para la cristalizacion de aspartama.

Info

Publication number
MX9304719A
MX9304719A MX9304719A MX9304719A MX9304719A MX 9304719 A MX9304719 A MX 9304719A MX 9304719 A MX9304719 A MX 9304719A MX 9304719 A MX9304719 A MX 9304719A MX 9304719 A MX9304719 A MX 9304719A
Authority
MX
Mexico
Prior art keywords
solution
aspartama
crystallization
aspartame
forced convection
Prior art date
Application number
MX9304719A
Other languages
English (en)
Inventor
Marinus Petrus Wilhelm Rijkers
Alexander Peter Marie Virinzen
Original Assignee
Holland Sweetener Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co filed Critical Holland Sweetener Co
Publication of MX9304719A publication Critical patent/MX9304719A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Esta invención se refiere a un procedimiento para la cristalización de aspartama (aspartamo) por neutralización con una base de una solución acuosa de aspartama, que tiene un pH inferior a 3, y homogeneización de la solución mediante convección forzada, caracterizado porque la solución se neutraliza y homogeneiza de manera tal que la solución obtenida es sustancialmente homogénea y tiene un pH superior a 3, dejando de agitar mecánicamente la solución por lo menos desde el inicio del último segundo antes de que la cristalización sea visualmente perceptible.
MX9304719A 1992-08-05 1993-08-04 Proceso para la cristalizacion de aspartama. MX9304719A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL9201408A NL9201408A (nl) 1992-08-05 1992-08-05 Werkwijze voor het kristalliseren van aspartaam.

Publications (1)

Publication Number Publication Date
MX9304719A true MX9304719A (es) 1994-05-31

Family

ID=19861149

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304719A MX9304719A (es) 1992-08-05 1993-08-04 Proceso para la cristalizacion de aspartama.

Country Status (10)

Country Link
US (1) US5502238A (es)
EP (1) EP0582351B1 (es)
KR (1) KR100294280B1 (es)
CN (1) CN1041205C (es)
AT (1) ATE175208T1 (es)
DE (1) DE69322820T2 (es)
MX (1) MX9304719A (es)
NL (1) NL9201408A (es)
RU (1) RU2112771C1 (es)
TW (1) TW321631B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108907A0 (en) * 1994-03-09 1994-06-24 Yissum Res Dev Co Aspartame and process for the preparation thereof
EP0733641A1 (en) * 1995-03-20 1996-09-25 Holland Sweetener Company V.O.F. Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
CA2172022A1 (en) * 1995-03-20 1996-09-21 Tsugio Murakami Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
RU2205188C2 (ru) 1998-06-30 2003-05-27 Ново Нордиск А/С Затравочные кристаллы для получения пептидов или протеинов
CN1307589A (zh) * 1998-06-30 2001-08-08 诺沃挪第克公司 用于制备肽或蛋白质的晶种晶体
KR20000009984A (ko) * 1998-07-29 2000-02-15 고두모 알파-엘-아스파틸-엘-페닐알라닌 메틸 에스테르의 결정화 방법
US6423864B1 (en) * 1998-11-25 2002-07-23 The Nutrasweet Company Purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via crystallization
US6281380B1 (en) * 2000-05-18 2001-08-28 The Nutra Sweet Company Synthesis of N-(N-(3,3-dimethylbutyl)-L-α-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
JP2003159026A (ja) * 2001-11-22 2003-06-03 Ajinomoto Co Inc 安定なアスパルテームスラリーの製造方法及び判定方法
CN107868117B (zh) * 2016-09-28 2021-04-23 中国科学院苏州纳米技术与纳米仿生研究所 司坦唑醇糖精盐及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE810577L (en) * 1983-05-31 1982-09-16 Prendergast Angela Apparatus for fermentation
JPS58177952A (ja) * 1982-04-12 1983-10-18 Ajinomoto Co Inc Ｌ−α−アスパルチル−Ｌ−フエニルアラニンメチルエステルの晶析法
GB2140805B (en) * 1983-05-31 1986-08-13 Erba Farmitalia Isolation of aspartame
JP2927070B2 (ja) * 1991-05-23 1999-07-28 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
JP2970107B2 (ja) * 1991-05-23 1999-11-02 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法

Also Published As

Publication number Publication date
CN1041205C (zh) 1998-12-16
DE69322820D1 (de) 1999-02-11
EP0582351A1 (en) 1994-02-09
KR100294280B1 (ko) 2001-09-17
CN1092429A (zh) 1994-09-21
EP0582351B1 (en) 1998-12-30
ATE175208T1 (de) 1999-01-15
RU2112771C1 (ru) 1998-06-10
TW321631B (es) 1997-12-01
DE69322820T2 (de) 1999-08-19
US5502238A (en) 1996-03-26
NL9201408A (nl) 1994-03-01
KR940005552A (ko) 1994-03-21

Similar Documents

Publication Publication Date Title
MA23091A1 (fr) Procede de preparation d'agents antiparasitaires .
DE69433010D1 (de) Verfahren zur darstellung von oligonukleotiden
DK0715631T3 (da) Fremgangsmåde til fremstilling af N-amino-1-hydroxyalkyliden-1,1-diphosphonsyrer
BR9200317A (pt) Composto termoconformavel e processo para a preparacao do mesmo
ATE83660T1 (de) Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.
FR2689282B1 (fr) Procede de controle de la navigation maritime.
MX9304719A (es) Proceso para la cristalizacion de aspartama.
ATE176128T1 (de) Verfahren zur bekämpfung von bakterien- /pilzkrankheiten in pflanzen
ATE73670T1 (de) Lysozyme hydrochlorid und dikaliumglycyrrhizinat enthaltende loesung.
DE69425948D1 (de) Zusammensetzung mit verbesserter Wasserlöslichkeit, enthaltend eine Wasserunlösliche oder an Wasser schwerunlösliche Verbindung
DE3668621D1 (de) Verfahren zur herstellung von pteridinderivaten.
RO92477A (ro) Procedeu de preparare pe cale microbiologica a l-carnitinei
DE69612908D1 (de) Verfahren zur Verbesserung der Biozidaktivität
DK0939086T3 (da) Fremgangsmåde til fremstilling af tværbunden hyaluronsyre
ATE193287T1 (de) Herstellung von derivaten von a-acetyl neuraminicsäuren
RU93043868A (ru) Способ кристаллизации аспартама
DE59608718D1 (de) Verfahren zur herstellung von substituierten 4,4'-diaminostilben-2,2'-disulfonsäuresalzen
PL238572A1 (en) Pesticide and method of manufacture of novel substituted diamides of hydroxymalonic acids
BR9002873A (pt) Composicao aquosa de condicionamento de cabelo e processo para aperfeicoar a elasticidade do cabelo
ATE48595T1 (de) Verfahren zur rueckgewinnung von 4,4'dihydroxydiphenylsulfonaus einer isomermischung.
BR9206468A (pt) Processo para produzir solução aquosa de ácido hipocloroso.
ATE191476T1 (de) Verfahren zur herstellung von indolderivaten
PT88254A (pt) Processo para a preparacao de derivados de eritromicina a modificada em c.12
ATE167668T1 (de) Verfahren zur herstellung von guaniden
DE69520947D1 (de) Diarinopropanole abgeleitet von aminosäuren

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees