MX9304502A - Tabletas dispersables en agua. - Google Patents
Tabletas dispersables en agua.Info
- Publication number
- MX9304502A MX9304502A MX9304502A MX9304502A MX9304502A MX 9304502 A MX9304502 A MX 9304502A MX 9304502 A MX9304502 A MX 9304502A MX 9304502 A MX9304502 A MX 9304502A MX 9304502 A MX9304502 A MX 9304502A
- Authority
- MX
- Mexico
- Prior art keywords
- disintegrating agent
- water
- tablet
- tablets dispersible
- dispersible
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- RRMBHRAGONDLTM-UHFFFAOYSA-N 2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)-1h-pyrimidin-2-amine Chemical compound C1CN(C)CCN1C1(N)N=CC(C=2C(=C(Cl)C=C(Cl)C=2)Cl)=CN1 RRMBHRAGONDLTM-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- -1 Alzheimer's disease Chemical compound 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000004927 clay Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000004565 water dispersible tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Paints Or Removers (AREA)
Abstract
Una tableta dispersable en agua que incluye 2-amino-2-(4-metilpiperazin-1-il)-5-(2,3,5-triclor ofenil)pirimidina, junto con un agente desintegrante de arcilla hinchable, y un agente desintegrante adicional. La tableta se puede utilizar en el tratamiento de desórdenes neurodegenerativos y otros desórdenes neurológicos del sistema nervioso central, cuya etiología incluye liberación excesiva de glutamato neurotransmisor, incluyendo enfermedades de Alzheimer, daño isquémico cerebral, dolor crónico, y epilepsia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929215908A GB9215908D0 (en) | 1992-07-27 | 1992-07-27 | Water dispersible tablets |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9304502A true MX9304502A (es) | 1994-06-30 |
Family
ID=10719356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9304502A MX9304502A (es) | 1992-07-27 | 1993-07-26 | Tabletas dispersables en agua. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5698221A (es) |
EP (1) | EP0652752B1 (es) |
JP (1) | JPH07509463A (es) |
AT (1) | ATE184486T1 (es) |
AU (1) | AU4717193A (es) |
DE (1) | DE69326470T2 (es) |
DK (1) | DK0652752T3 (es) |
ES (1) | ES2137267T3 (es) |
GB (1) | GB9215908D0 (es) |
GR (1) | GR3031679T3 (es) |
IL (1) | IL106492A0 (es) |
MX (1) | MX9304502A (es) |
WO (1) | WO1994002147A1 (es) |
ZA (1) | ZA935381B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0011180A (pt) * | 1999-03-29 | 2002-07-09 | American Home Prod | Sistema e métodos de revestimento para aplicação a unidades de dosagem farmacêutica sólidas e composição |
ATE319447T1 (de) * | 1999-08-16 | 2006-03-15 | Revaax Pharmaceuticals Llc | Pharmazeutische zubereitungen die clavulansäure oder derivate enthalten zur behandlund von neurologischen störungen |
US6489319B2 (en) * | 1999-08-16 | 2002-12-03 | Revaax Pharmaceuticals, Llc | Neurotherapeutic use of carboxypeptidase inhibitors |
US6426342B2 (en) * | 1999-08-16 | 2002-07-30 | Revaax Pharmaceuticals, Llc | Use of β-lactamase inhibitors as neuroprotectants |
GB0223978D0 (en) * | 2002-10-15 | 2002-11-20 | Novartis Ag | Organic compound |
US20070148229A1 (en) * | 2003-04-24 | 2007-06-28 | Jagotec Ag | Tablet with coloured core |
EP1700591A4 (en) | 2003-12-01 | 2011-08-03 | Takeda Pharmaceutical | PROCESS FOR TREATING SOLID PHARMACEUTICAL PREPARATION PRIOR TO PRINTING AND SOLID PHARMACEUTICAL PREPARATION SUBJECT TO PROCESSING BEFORE PRINTING |
GB0408078D0 (en) * | 2004-04-08 | 2004-05-12 | Novartis Ag | Organic compounds |
WO2007052289A2 (en) * | 2005-07-22 | 2007-05-10 | Rubicon Research Pvt Ltd. | Novel dispersible tablet composition |
JP2009512652A (ja) * | 2005-10-19 | 2009-03-26 | ノバルティス アクチエンゲゼルシャフト | 安息香酸誘導体含有分散錠 |
ES2400446T5 (es) | 2006-08-03 | 2017-03-13 | Horizon Pharma Ag | Tratamiento con glucocorticoides de liberación retardada de una enfermedad reumática |
CA2758029A1 (en) * | 2009-04-29 | 2011-11-04 | Rexahn Pharmaceuticals, Inc. | Clavulanate formulation for neuroprotection and treatment of neurodegenerative disorders |
Family Cites Families (66)
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---|---|---|---|---|
GB777516A (en) * | 1955-04-14 | 1957-06-26 | Griffiths Hughes Ltd E | Improvements in or relating to the production of tablets by pressure |
GB837451A (en) * | 1956-02-20 | 1960-06-15 | Arner Co Inc | Sustained release therapeutic composition and process of preparing same |
US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
US3427379A (en) * | 1966-01-13 | 1969-02-11 | Hoffmann La Roche | Dextromethorphan and benzyl alcohol hard candy lozenges free from opaqueness and/or tiny entrapped air bubbles |
NL6814269A (es) * | 1967-10-13 | 1969-04-15 | ||
DE2016622A1 (en) * | 1970-04-08 | 1971-10-21 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Anthelmintic benzimidazole deriv |
CA926708A (en) * | 1970-06-15 | 1973-05-22 | Oushima Yoshitaka | Process for producing spherical pellets |
US4072535A (en) * | 1970-12-28 | 1978-02-07 | A. E. Staley Manufacturing Company | Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules |
FR2183546B1 (es) * | 1972-05-10 | 1975-06-20 | Servier Lab | |
DE2251249A1 (de) * | 1972-10-19 | 1974-05-02 | Hoechst Ag | Verfahren zur herstellung von penicillin-verbindungen enthaltenden tabletten |
US4209513A (en) * | 1974-02-14 | 1980-06-24 | Burroughs Wellcome Co. | Tablet formulation |
DE2416903A1 (de) * | 1974-04-06 | 1975-10-09 | Bayer Ag | Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren |
JPS5154918A (en) * | 1974-10-08 | 1976-05-14 | Nippon Kayaku Kk | Jozaino seizoho |
US4086335A (en) * | 1975-10-29 | 1978-04-25 | Bruscato Frank N | Pharmaceutical tablets containing chitin as a disintegrant |
DE2560510C2 (es) * | 1975-11-26 | 1989-02-16 | Bayer Ag, 5090 Leverkusen, De | |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
AU508480B2 (en) * | 1977-04-13 | 1980-03-20 | Asahi Kasei Kogyo Kabushiki Kaisha | Microcrystalline cellulose excipient and pharmaceutical composition containing thesame |
CA1097233A (en) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
DE2849494A1 (de) * | 1978-11-15 | 1980-05-29 | Voss Gunter M | Verfahren zur herstellung von arzneimittel-formlingen |
HU182086B (en) * | 1979-06-01 | 1983-12-28 | Wellcome Found | Process for preparing new 1,2,4-triazine derivatives |
US4251518A (en) * | 1979-07-03 | 1981-02-17 | Ralston Purina Company | Method of preparing readily disintegrable pharmaceutical compositions |
US4304773A (en) * | 1980-06-26 | 1981-12-08 | E. R. Squibb & Sons, Inc. | Novel bendroflumethiazide formulations and method |
US4369308A (en) * | 1981-07-24 | 1983-01-18 | National Starch And Chemical Corporation | Low swelling starches as tablet disintegrants |
HU189534B (en) * | 1981-09-09 | 1986-07-28 | Chinoin Rt.,Hu | Process for producing new tablets containing cyclodextrin polymer as desintegrator |
DE3142826A1 (de) * | 1981-10-29 | 1983-05-11 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur herstellung einer hochreaktiven pechfraktion und deren verwendung |
US4517179A (en) * | 1983-04-29 | 1985-05-14 | Pennwalt Corporation | Rapid dissolving, uniform drug compositions and their preparation |
US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
US4631305A (en) * | 1985-03-22 | 1986-12-23 | The Upjohn Company | Polymeric material as a disintegrant in a compressed tablet |
EP0199855A1 (en) * | 1985-05-02 | 1986-11-05 | Gist-Brocades N.V. | Tablets comprising tromethoprim and a sulfonamide |
US4832956A (en) * | 1985-09-25 | 1989-05-23 | Gerhard Gergely | Disintegrating tablet and process for its preparation |
US4781925A (en) * | 1986-03-06 | 1988-11-01 | American Home Products Corporation | Calcium supplement compressed tablets |
KR880701098A (ko) * | 1986-04-01 | 1988-07-25 | 로버어트 에이 아미테이지 | 메틸프레드니솔론/소디움 카르복시메틸 전분 정제 조성물 |
GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
DE3635864A1 (de) * | 1986-06-26 | 1988-05-05 | Gerhard Gergely | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
KR960001372B1 (ko) * | 1986-09-24 | 1996-01-26 | 예일 유니버시티 | 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질 |
US4771077A (en) * | 1986-10-21 | 1988-09-13 | American Home Products Corporation (Del.) | Spray dried acetaminophen |
GB8628359D0 (en) * | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
DE3887179T2 (de) * | 1987-03-02 | 1994-06-16 | Brocades Pharma Bv | Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung. |
ATE73328T1 (de) * | 1987-05-08 | 1992-03-15 | Smith Kline French Lab | Pharmazeutische zusammensetzungen. |
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DE3773926D1 (de) * | 1987-07-22 | 1991-11-21 | Farvalsa Ag | Feuchtigkeitsstabile feste valproinsaeure-zubereitung und verfahren zu ihrer herstellung. |
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US4837031A (en) * | 1987-09-17 | 1989-06-06 | Mallinckrodt, Inc. | Compositions containing ibuprofen |
US4999200A (en) * | 1987-12-09 | 1991-03-12 | Marion Laboratories | Psyllium tablet composition, method of manufacture and method of use |
DE68916983T2 (de) * | 1988-02-25 | 1995-01-19 | Yamanouchi Europ Bv | Verfahren zur Herstellung eines pharmazeutischen Granulats. |
US4910023A (en) * | 1988-06-09 | 1990-03-20 | Warner-Lambert Company | Drug in combination with flavor masking agent and method for making same |
YU120988A (en) * | 1988-06-23 | 1990-06-30 | Lek Tovarna Farmacevtskih | Process for preparing new dispersion pills of cimetidine |
IT1226549B (it) * | 1988-07-12 | 1991-01-24 | Resa Farma | Composizioni farmaceutiche ad attivita' analgesica ed antiinfiammatoria per uso orale, dotate di ottima palatabilita' ed esenti da effetti irritanti sulle mucose. |
YU183988A (en) * | 1988-09-30 | 1990-08-31 | Lek Tovarna Farmacevtskih | Process for preparing dispersion pills of dihydroergotoxine |
US4965072A (en) * | 1988-11-03 | 1990-10-23 | Miles Inc. | Granulating composition and method |
US5073377A (en) * | 1988-11-03 | 1991-12-17 | Miles Inc. | Method of preparing oral dosage forms with a granulating composition |
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
US4927639A (en) * | 1989-02-02 | 1990-05-22 | Warner-Lambert Company | Modified release gemfibrozil composition |
US4925676A (en) * | 1989-02-02 | 1990-05-15 | Warner-Lambert Company | Extended release gemfibrozil composition |
ES2055894T3 (es) * | 1989-04-07 | 1994-09-01 | Ciba Geigy Ag | Concentrados de sustancias activas pesticidas y su preparacion. |
US4970078A (en) * | 1989-05-25 | 1990-11-13 | Aqualon Company | Crosslinked carboxymethyguar tablet disintegrant |
DE59003811D1 (de) * | 1989-09-07 | 1994-01-20 | Thomas Gergely | Magensäure bindende, pharmazeutische zubereitung. |
US5037658A (en) * | 1989-09-14 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Direct dry compressible acetaminophen composition |
US5064656A (en) * | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
GB9012316D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
US5087454A (en) * | 1990-07-30 | 1992-02-11 | American Home Products Corporation | Ibuprofen tablet |
GB9025372D0 (en) * | 1990-11-22 | 1991-01-09 | Nat Res Dev | Pharmaceutical dosage forms |
-
1992
- 1992-07-27 GB GB929215908A patent/GB9215908D0/en active Pending
-
1993
- 1993-07-26 MX MX9304502A patent/MX9304502A/es unknown
- 1993-07-26 ZA ZA935381A patent/ZA935381B/xx unknown
- 1993-07-27 EP EP93917926A patent/EP0652752B1/en not_active Expired - Lifetime
- 1993-07-27 AU AU47171/93A patent/AU4717193A/en not_active Abandoned
- 1993-07-27 JP JP6504326A patent/JPH07509463A/ja active Pending
- 1993-07-27 DK DK93917926T patent/DK0652752T3/da active
- 1993-07-27 WO PCT/GB1993/001586 patent/WO1994002147A1/en active IP Right Grant
- 1993-07-27 ES ES93917926T patent/ES2137267T3/es not_active Expired - Lifetime
- 1993-07-27 IL IL106492A patent/IL106492A0/xx unknown
- 1993-07-27 AT AT93917926T patent/ATE184486T1/de not_active IP Right Cessation
- 1993-07-27 DE DE69326470T patent/DE69326470T2/de not_active Expired - Fee Related
- 1993-07-27 US US08/374,728 patent/US5698221A/en not_active Expired - Fee Related
-
1999
- 1999-10-27 GR GR990402769T patent/GR3031679T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3031679T3 (en) | 2000-02-29 |
GB9215908D0 (en) | 1992-09-09 |
ZA935381B (en) | 1995-01-26 |
DK0652752T3 (da) | 2000-03-20 |
EP0652752B1 (en) | 1999-09-15 |
ATE184486T1 (de) | 1999-10-15 |
DE69326470D1 (de) | 1999-10-21 |
DE69326470T2 (de) | 2000-01-13 |
JPH07509463A (ja) | 1995-10-19 |
WO1994002147A1 (en) | 1994-02-03 |
EP0652752A1 (en) | 1995-05-17 |
IL106492A0 (en) | 1993-11-15 |
AU4717193A (en) | 1994-02-14 |
ES2137267T3 (es) | 1999-12-16 |
US5698221A (en) | 1997-12-16 |
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