ES2133975T3 - Compuestos de 4a-arildecahidroisoquinolina y usos medicinales de los mismos. - Google Patents
Compuestos de 4a-arildecahidroisoquinolina y usos medicinales de los mismos.Info
- Publication number
- ES2133975T3 ES2133975T3 ES96924167T ES96924167T ES2133975T3 ES 2133975 T3 ES2133975 T3 ES 2133975T3 ES 96924167 T ES96924167 T ES 96924167T ES 96924167 T ES96924167 T ES 96924167T ES 2133975 T3 ES2133975 T3 ES 2133975T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- present
- cerebral
- neuros
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE 4AARILDECAHIDROISOQUINOLINA, EL CUAL ESTA REPRESENTADO POR UN COMPUESTO 1, O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO. COMO RESULTADOS DE EVALUACIONES FARMACOLOGICAS IN VITRO E IN VIVO, SE VIO QUE LOS COMPUESTOS DE LA PRESENTE INVENCION TENIAN EXCELENTES EFECTOS PREVENTIVOS EN MUERTE ISQUEMICA DE NEUROCITOS CEREBRALES, EFECTOS SUPRESIVOS EN EL DESARROLLO DE INFARTO CEREBRAL, Y POTENTES EFECTOS ANALGESICOS Y ANTITUSIVOS; POR TANTO LOS COMPUESTOS DE LA PRESENTE INVENCION PUEDEN SER UTILIZADOS EN EL CAMPO MEDICINAL COMO UN UTIL AGENTE CITOPROTECTOR CEREBRAL, EL CUAL ESTA DIRIGIDO A LA PREVENCION Y TRATAMIENTO DE TRASTORNOS CEREBROVASCULARES, TRASTORNOS CEREBRALES ISQUEMICOS, TRASTORNOS DE NEUROCITO CEREBRAL, Y DEMENCIA, UN ANALGESICO, Y UN ANTITUSIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18381195 | 1995-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133975T3 true ES2133975T3 (es) | 1999-09-16 |
Family
ID=16142292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96924167T Expired - Lifetime ES2133975T3 (es) | 1995-07-20 | 1996-07-19 | Compuestos de 4a-arildecahidroisoquinolina y usos medicinales de los mismos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5776945A (es) |
EP (1) | EP0787721B1 (es) |
JP (1) | JP3858273B2 (es) |
KR (1) | KR970706258A (es) |
CN (1) | CN1163487C (es) |
AU (1) | AU6470996A (es) |
CA (1) | CA2200324C (es) |
DE (2) | DE69602248D1 (es) |
ES (1) | ES2133975T3 (es) |
TW (1) | TW430657B (es) |
WO (1) | WO1997003968A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2383146C (en) * | 1999-08-24 | 2010-11-16 | Hiroshi Nagase | Therapeutic agent for neuropathic pain and neuropathic pain animal model |
JP6020459B2 (ja) * | 2011-10-18 | 2016-11-02 | アステラス製薬株式会社 | 二環式ヘテロ環化合物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301290A (en) * | 1975-12-16 | 1981-11-17 | Sandoz Ltd. | Organic compounds |
DE2655150A1 (de) * | 1975-12-16 | 1977-06-23 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
AT371445B (de) * | 1977-05-24 | 1983-06-27 | Sandoz Ag | Verfahren zur herstellung von neuen cis-4a-phenyl-isochinolinderivaten und ihren saeureadditionssalzen |
DE2907461A1 (de) * | 1978-03-10 | 1979-09-20 | Sandoz Ag | Isochinolinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
US4189583A (en) * | 1978-04-26 | 1980-02-19 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of 4A-aryl-decahydroisoquinolines |
US5244904A (en) * | 1990-06-05 | 1993-09-14 | Toray Industries, Inc. | Indole derivatives |
JPH04297458A (ja) * | 1991-03-27 | 1992-10-21 | Toray Ind Inc | イソキノリン誘導体およびその製造方法 |
JP2985322B2 (ja) * | 1991-03-01 | 1999-11-29 | 東レ株式会社 | イソキノリン誘導体およびその医薬用途 |
JPH05155857A (ja) * | 1991-12-03 | 1993-06-22 | Toray Ind Inc | 4a−アリールデカヒドロイソキノリン誘導体および鎮痛剤 |
-
1996
- 1996-07-19 WO PCT/JP1996/002030 patent/WO1997003968A1/ja not_active Application Discontinuation
- 1996-07-19 JP JP50654497A patent/JP3858273B2/ja not_active Expired - Fee Related
- 1996-07-19 ES ES96924167T patent/ES2133975T3/es not_active Expired - Lifetime
- 1996-07-19 KR KR1019970701817A patent/KR970706258A/ko not_active Application Discontinuation
- 1996-07-19 CN CNB961910666A patent/CN1163487C/zh not_active Expired - Fee Related
- 1996-07-19 DE DE69602248A patent/DE69602248D1/de not_active Expired - Fee Related
- 1996-07-19 CA CA002200324A patent/CA2200324C/en not_active Expired - Fee Related
- 1996-07-19 AU AU64709/96A patent/AU6470996A/en not_active Abandoned
- 1996-07-19 DE DE69602248T patent/DE69602248T4/de not_active Expired - Lifetime
- 1996-07-19 EP EP96924167A patent/EP0787721B1/en not_active Expired - Lifetime
- 1996-07-19 US US08/809,226 patent/US5776945A/en not_active Expired - Fee Related
- 1996-09-05 TW TW085110865A patent/TW430657B/zh active
Also Published As
Publication number | Publication date |
---|---|
CN1163487C (zh) | 2004-08-25 |
WO1997003968A1 (fr) | 1997-02-06 |
CA2200324A1 (en) | 1997-02-06 |
EP0787721A1 (en) | 1997-08-06 |
JP3858273B2 (ja) | 2006-12-13 |
CA2200324C (en) | 2008-07-08 |
KR970706258A (ko) | 1997-11-03 |
AU6470996A (en) | 1997-02-18 |
TW430657B (en) | 2001-04-21 |
DE69602248D1 (de) | 1999-06-02 |
US5776945A (en) | 1998-07-07 |
EP0787721B1 (en) | 1999-04-28 |
DE69602248T2 (de) | 1999-09-23 |
EP0787721A4 (es) | 1997-09-17 |
DE69602248T4 (de) | 2000-10-26 |
CN1165513A (zh) | 1997-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA28009A1 (fr) | Derives de pyridazine et utilisation de ceux-ci en tant qu'agents therapeutiques | |
BR9908474A (pt) | Preparação de liberação prolongada, processo para a produção de uma preparação de liberação prolongada, e, composição farmacêutica | |
ES2139132T3 (es) | Composiciones farmaceuticas activas en la terapia de desordenes del sueño. | |
ATE378058T1 (de) | Cannabis extrakten pharmazeutische zusammensetzung | |
HN1997000052A (es) | Nuevas 4(3h)--quinazolinas 2,3-disustituidas | |
BR9611015A (pt) | Composto, composição farmacêutica e processo para o tratamento de uma doença inflamatória suscetìvel ao tratamento com um agente não-tóxico anti-inflamatório não-esteróide, sal farmaceuticamente aceitável, utilização de um composto | |
ECSP014065A (es) | Una composicion farmaceutica y procedimiento de tratamiento de enfermedades de disfuncion cognitiva en un mamifero | |
DK1346041T3 (da) | Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom | |
BRPI9710372B8 (pt) | composto, e, composição farmacêutica. | |
ES2178430T3 (es) | Utilizacion de composiciones farmaceuticas gelificables en parodontologia. | |
BR9810312A (pt) | Composição farmacêutica que apresenta atividade antitumoral acentuada e/ou efeitos colaterais reduzidos contendo um agente antitumoral e um derivado do ácido hidroxìmico | |
MX9300977A (es) | Compuetos heterobiciclicos. | |
KR940005285A (ko) | 염증성 장 질환, 염증성 피부 질환 및 자반증의 예방 및 치료용 약제제조를 위한 상보적 억제제의 용도 | |
BR0013540A (pt) | Formulações farmacêuticas e seu uso na prevenção de acidente vascular cerebral, diabetes e/ou falha de coração congestiva | |
ES2074698T3 (es) | Composicion oral para el tratamiento de enfermedades intestinales inflamatorias. | |
Capasso et al. | Reduction of agonist‐induced contractions of guinea‐pig isolated ileum by flavonoids | |
DK1104758T3 (da) | Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler | |
CO5590913A2 (es) | Terapia de combinacion antivirica | |
MX9306234A (es) | Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen. | |
AR040248A1 (es) | Farmaco para el tratamiento de la vejiga hiperactiva | |
ZA202210355B (en) | Compositions and therapeutic uses of cannabidiol | |
ES2184097T3 (es) | Nuevos compuestos. | |
ES2139673T3 (es) | Utilizacion de norastemizol para el tratamiento de rinitis alergica. | |
KR970025615A (ko) | 암 전이 억제제 | |
CO5011084A1 (es) | Composiciones y metodos para tratar trastornos respiratorios |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 787721 Country of ref document: ES |