GB777516A - Improvements in or relating to the production of tablets by pressure - Google Patents
Improvements in or relating to the production of tablets by pressureInfo
- Publication number
- GB777516A GB777516A GB1072855A GB1072855A GB777516A GB 777516 A GB777516 A GB 777516A GB 1072855 A GB1072855 A GB 1072855A GB 1072855 A GB1072855 A GB 1072855A GB 777516 A GB777516 A GB 777516A
- Authority
- GB
- United Kingdom
- Prior art keywords
- powdered
- substance
- waxy
- waxy substance
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Abstract
In the production of pressed tablets containing a proportion of wax (or other substance of a waxy nature) of the order of 25 per cent. by weight, the waxy substance is melted or dissolved and then absorbed in an absorbent solid. The tendency of the waxy substance to clog the tablet-making machine is thus reduced. The waxy substance may be a fatty alcohol or a fatty alcohol ester, such as spermaceti. The absorbent solid may serve only as a carrier for the waxy substance and may be powdered chalk, koilin or fuller's earth. Alternatively the absorbent solid may serve an additional purpose and may be a laxative, e.g. a cellulose derivative such as methyl cellulose, magnesium carbonate, powdered senna, powdered cascara or magnesium sulphate. In this application magnesium hydroxide and lactose may also be added, and the mixture may then be granulated, e.g. with the aid of acacia solution, and sieved. The granules may then be dried, disintegrants and lubricants may be added and finally the mixture is pressed in a tablet-producing machine. The Provisional Specification mentions phenolphthalein as an optional constituuent of the compositions.ALSO:In the production of pressed tablets containing a proportion of wax (or other substance of a waxy nature) of the order of 25 per cent by weight, the waxy substance is melted or dissolved and then absorbed in an absorbent solid. The tendency of the waxy substance to clog the tablet-making machine is thus reduced. The waxy substance may be a fatty alcohol or a fatty alcohol ester, such as spermaceti. The absorbent solid may serve only as a carrier for the waxy substance and may be powdered chalk, kaolin or fuller's earth. Alternatively the absorbent solid may serve an additional purpose and may be a laxative, e.g. a cellulose derivative such as methyl cellulose, magnesium carbonate, powdered senna, powdered cascara or magnesium sulphate. In this application magnesium hydroxide and lactose may also be added, and the mixture may then be granulated, e.g. with the aid of acacia solution, and sieved. The granules may then be dried, disintegrants and lubricants may be added and finally the mixture is pressed in a tablet-producing mixture is pressed in a tablet-producing machine. The provisional Specification mentions phenolphthalein as an optional constituent of the compositions.ALSO:In the production of pressed tablets containing a proportion of wax (or other substance of a waxy nature) of the order of 25 per cent by weight, the waxy substance is melted or dissolved and then absorbed in an absorbent solid. The tendency of the waxy substance to clog the tablet-making machine is thus reduced. The waxy substance may be a fatty alcohol or a fatty alcohol ester, such as spermaceti. The absorbent solid may serve only as a carrier for the waxy substance and may be powdered chalk, kaolin or fuller's earth. Alternatively the absorbent solid may serve an additional purpose and may be a laxative, e.g. a cellulose derivative such as methyl cellulose, magnesium carbonate, powdered senna, powdered cascara or magnesium sulphate. In this application magnesium hydroxide and lactose may also be added, and the mixture may then be granulated, e.g. with the aid of acacia solution, and sieved. The granules may then be dried, disintegrants and lubricants may be added and finally the mixture is pressed in a tablet-producing machine. The provisional Specification mentions phenolphthalein as an optional constituent of the compositions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1072855A GB777516A (en) | 1955-04-14 | 1955-04-14 | Improvements in or relating to the production of tablets by pressure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1072855A GB777516A (en) | 1955-04-14 | 1955-04-14 | Improvements in or relating to the production of tablets by pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB777516A true GB777516A (en) | 1957-06-26 |
Family
ID=9973190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1072855A Expired GB777516A (en) | 1955-04-14 | 1955-04-14 | Improvements in or relating to the production of tablets by pressure |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB777516A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556639A (en) * | 1991-01-30 | 1996-09-17 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5698221A (en) * | 1992-07-27 | 1997-12-16 | Patel; Suryakant Dahyabhai | Water-dispersible tablets |
-
1955
- 1955-04-14 GB GB1072855A patent/GB777516A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556639A (en) * | 1991-01-30 | 1996-09-17 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5660860A (en) * | 1991-01-30 | 1997-08-26 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| US5698221A (en) * | 1992-07-27 | 1997-12-16 | Patel; Suryakant Dahyabhai | Water-dispersible tablets |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
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