ES228926A1 - Procedure for the preparation of substitute 2-oxo-benzoquinolicines (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the preparation of substitute 2-oxo-benzoquinolicines (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of ES228926A1publicationCriticalpatent/ES228926A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Process for the preparation of substituted 2-oxo-benzoquinolizins, characterized in that, according to Nannich, a 1-carbalkoxymethyl-1,2,3,4-tetrahydroisoquinoline is reacted whose isocyclic nucleus can be partially hydrogenated and contain hydroxy or alkoxy groups optionally linked together, with formaldehyde or a compound yielding formaldehyde and a substituted malonic acid whose substituent is an alkyl, alkenyl or aralkoyl radical which may contain oxygen in the form of an ether functional group or with the dimethyl ester of such a substituted malonic acid, all free carboxyl groups that are still present in the resulting condensation product are esterified, the resulting tricarboxylic ester is subjected to a Dieckmann condensation with the aid of an alkaline condensation agent and the resultant tricyclic ketodicarboxyl ester is saponified and decarboxylated. (Machine-translation by Google Translate, not legally binding)
ES0228926A1955-12-221956-06-02Procedure for the preparation of substitute 2-oxo-benzoquinolicines (Machine-translation by Google Translate, not legally binding)
ExpiredES228926A1
(en)
A procedure for the preparation of alpha-methyl 9 alfafluoro delta1-corticosterone and its esters. (Machine-translation by Google Translate, not legally binding)
A procedure for obtaining tenseactive products by sterification of alkyl carboxylic acids of high molecular weight (Machine-translation by Google Translate, not legally binding)