GB797508A - Improvements in or relating to therapeutically valuable cysteine compounds - Google Patents
Improvements in or relating to therapeutically valuable cysteine compoundsInfo
- Publication number
- GB797508A GB797508A GB8698/57A GB869857A GB797508A GB 797508 A GB797508 A GB 797508A GB 8698/57 A GB8698/57 A GB 8698/57A GB 869857 A GB869857 A GB 869857A GB 797508 A GB797508 A GB 797508A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cysteine
- methyl alcohol
- water
- mixture
- small amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cysteine methyl ester hydrochloride is prepared by reacting cysteine hydrochloride with at least 4 molecular equivalents of methyl alcohol in the presence of hydrochloric acid. In an example, the reaction is effected at the boiling point while passing hydrogen chloride through the mixture. The product can be purified by recrystallization from methyl alcohol, from a mixture of methyl alcohol with dry ethyl acetate or dry ethyl ether or from dioxane, either mixed with a small amount of water alone or with a small amount of water and methanol. The free base can be liberated and converted to the neutral sulphate.ALSO:The invention comprises a therapeutic composition consisting of a buffered aqueous solution of cysteine methyl ester hydrochloride. A suitable aqueous buffer solution is one which by itself has a pH of 7, such as is obtained by dissolving citric acid and disodium phosphate in water. The preparation of the pure ester-salt is described (see Group IV (b)).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR797508X | 1954-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB797508A true GB797508A (en) | 1958-07-02 |
Family
ID=9235722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8698/57A Expired GB797508A (en) | 1954-09-15 | 1955-09-08 | Improvements in or relating to therapeutically valuable cysteine compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB797508A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1297830A1 (en) * | 2001-09-28 | 2003-04-02 | Flamma Fabbrica Lombarda Ammino Acidi S.p.a. | Use of alpha- or beta-amino acids, of the corresponding esters or of dipeptides of these amino acids with histidine derivatives in the prevention or treatment of tissue damage caused by a atmospheric ozone |
-
1955
- 1955-09-08 GB GB8698/57A patent/GB797508A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1297830A1 (en) * | 2001-09-28 | 2003-04-02 | Flamma Fabbrica Lombarda Ammino Acidi S.p.a. | Use of alpha- or beta-amino acids, of the corresponding esters or of dipeptides of these amino acids with histidine derivatives in the prevention or treatment of tissue damage caused by a atmospheric ozone |
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