MX9302824A - Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca - Google Patents

Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca

Info

Publication number
MX9302824A
MX9302824A MX9302824A MX9302824A MX9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A MX 9302824 A MX9302824 A MX 9302824A
Authority
MX
Mexico
Prior art keywords
piridazo
diazepina
piridazina
pirazolo
peptides
Prior art date
Application number
MX9302824A
Other languages
English (en)
Spanish (es)
Inventor
Gary A Flynn
Patrick W Shum
Original Assignee
Merrell Dow Pahmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pahmaceuticals Inc filed Critical Merrell Dow Pahmaceuticals Inc
Publication of MX9302824A publication Critical patent/MX9302824A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
MX9302824A 1992-05-15 1993-05-14 Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca MX9302824A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US4000393A 1993-04-09 1993-04-09

Publications (1)

Publication Number Publication Date
MX9302824A true MX9302824A (es) 1994-05-31

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302824A MX9302824A (es) 1992-05-15 1993-05-14 Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca

Country Status (19)

Country Link
US (1) US5366973A (Direct)
EP (1) EP0640086B1 (Direct)
JP (1) JP3360079B2 (Direct)
KR (1) KR100281450B1 (Direct)
AT (1) ATE182892T1 (Direct)
AU (1) AU669364B2 (Direct)
CA (1) CA2133963C (Direct)
DE (1) DE69325904T2 (Direct)
DK (1) DK0640086T3 (Direct)
ES (1) ES2138622T3 (Direct)
FI (1) FI108230B (Direct)
GR (1) GR3031287T3 (Direct)
HU (1) HU223663B1 (Direct)
IL (1) IL105680A (Direct)
MX (1) MX9302824A (Direct)
NO (1) NO302573B1 (Direct)
NZ (1) NZ251930A (Direct)
TW (1) TW270115B (Direct)
WO (1) WO1993023403A1 (Direct)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
HUT71494A (en) * 1993-06-11 1995-11-28 Eisai Co Ltd Pharmaceutical compositions containing of condensed heterocyclic amino acid derivatives
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
NZ279396A (en) * 1994-02-14 1997-08-22 Merrell Pharma Inc Octahydro-6-hetring[2,1-a][2]benzazepine disulphide derivatives
WO1995021854A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0751783B1 (en) * 1994-03-24 2000-02-02 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
EP1053246B1 (en) * 1998-02-12 2003-01-02 Molecumetics, Ltd. Beta-sheet mimetics and methods relating to the use thereof
IT1298268B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico
FR2777889B1 (fr) 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PT1087775E (pt) 1998-06-17 2005-11-30 Bristol Myers Squibb Co Prevencao de enfarte cerebral por administracao de uma combinacao de farmacos antiplaquetarios bloqueadores de receptores de adp e anti-hipertensivos
US6177565B1 (en) 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
CZ300687B6 (cs) * 1999-08-30 2009-07-15 Sanofi - Aventis Deutschland GmbH Léciva s obsahem ramiprilu k ošetrování kardiovaskulárních príhod
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US6821971B2 (en) * 2001-09-20 2004-11-23 The Procter & Gamble Company Fused pyrazolone compounds which inhibit the release of inflammatory cytokines
EP1443919A4 (en) * 2001-11-16 2006-03-22 Bristol Myers Squibb Co DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
US7459474B2 (en) * 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US20050054731A1 (en) * 2003-09-08 2005-03-10 Franco Folli Multi-system therapy for diabetes, the metabolic syndrome and obesity
US7371759B2 (en) * 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
CA2614664A1 (en) * 2005-07-14 2007-01-25 Franco Folli Daily dosage regimen for treating diabetes, obesity,metabolic syndrome and polycystic ovary syndrome
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CN101432025B (zh) 2006-03-21 2012-04-04 安米林药品公司 肽-肽酶抑制剂结合物及其使用方法
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
JP2009538356A (ja) 2006-05-26 2009-11-05 アミリン・ファーマシューティカルズ，インコーポレイテッド 鬱血性心不全の治療のための組成物および方法
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
US7968577B2 (en) 2006-11-01 2011-06-28 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US8198311B2 (en) 2006-11-01 2012-06-12 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057855A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2195034A2 (en) 2007-09-27 2010-06-16 Amylin Pharmaceuticals, Inc. Peptide-peptidase inhibitor conjugates and methods of making and using same
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CN102149710A (zh) 2008-06-24 2011-08-10 百时美施贵宝公司 糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN106674228B (zh) * 2016-12-09 2018-12-04 河南农业大学 多元杂环化合物及其制备方法和用途
WO2022269913A1 (ja) * 2021-06-25 2022-12-29 株式会社日立産機システム 劣化診断装置および劣化診断方法、並びに電動機制御装置

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
ATE60605T1 (de) * 1985-04-30 1991-02-15 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
CA1337654C (en) * 1986-06-13 1995-11-28 Gary A. Flynn Fused tricyclic lactams as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
NZ241023A (en) * 1990-12-21 1994-10-26 Merrell Dow Pharma Condensed benzazepine derivatives and pharmaceutical compositions
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
CA2119019A1 (en) * 1991-09-16 1993-04-01 Harry R. Davis Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation

Also Published As

Publication number Publication date
IL105680A (en) 1998-01-04
TW270115B (Direct) 1996-02-11
DK0640086T3 (da) 1999-12-06
CA2133963A1 (en) 1993-11-25
HU223663B1 (hu) 2004-11-29
FI945363A0 (fi) 1994-11-14
GR3031287T3 (en) 1999-12-31
IL105680A0 (en) 1993-09-22
ES2138622T3 (es) 2000-01-16
AU4033293A (en) 1993-12-13
EP0640086A1 (en) 1995-03-01
JP3360079B2 (ja) 2002-12-24
NO944335L (no) 1995-01-13
EP0640086B1 (en) 1999-08-04
JPH07506832A (ja) 1995-07-27
HUT71099A (en) 1995-11-28
AU669364B2 (en) 1996-06-06
US5366973A (en) 1994-11-22
FI108230B (fi) 2001-12-14
NO302573B1 (no) 1998-03-23
KR100281450B1 (ko) 2001-02-01
CA2133963C (en) 1998-07-07
WO1993023403A1 (en) 1993-11-25
DE69325904T2 (de) 1999-12-09
DE69325904D1 (de) 1999-09-09
NZ251930A (en) 1996-02-27
NO944335D0 (no) 1994-11-14
KR950701634A (ko) 1995-04-28
FI945363L (fi) 1994-11-14
ATE182892T1 (de) 1999-08-15

Similar Documents

Publication Publication Date Title
MX9302824A (es) Nuevos derivados de mecaptoacetilamido piridazo (1,2)piridazina, pirazolo (1, 2)piridazina, piridazo(1, 2-a)(1, 2) diazepina y pirazolo (1, 2-a)(1, 2) diazepina, utiles como inhibidores de la encefaliasa y eca
MX9302906A (es) Derivados de mercaptoacetilamida novedosos utiles como inhibidores de la encefalinasa.
PT883687E (pt) Receptores de quimiocinas c-c, ckr-5, cc, os seus derivados e as suas utilizacoes
BR9708887A (pt) Variante de uma alfa-amilase uso de mesma construção de dna vetor de expressão recombinante célula aditivo e composição detergente e processo para gerar uma variante de uma alfa-amilase
ES2008974A6 (es) Formulacion liquida de enzimas para aplicacion tecnica, utilizaciones y procedimientos de empleo para desencalado, adobo, remojo y desengrasado de pieles en tripa.
DE69429822D1 (de) Abschuppende zusammensetzung von salicylsäure und zwitterionischen verbindungen
DE69414756D1 (de) Stromversorgung für eine elektrostatische Sprühpistole
ES2094141T3 (es) 1h-imidazo(4,5-c)quinolin-4-aminas como antivirales.
DE69713887D1 (de) Herstellung von verzweigten tensiden
BR8303578A (pt) Composicao condicionadora de enxague de cabelo, liquida, de uma unica fase, limpida e aquosa e metodo para condicionar cabelo
ES2104134T3 (es) Mejoras en composiciones para limpieza o relativas a ellas.
ES2117426T3 (es) Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico.
EP0156106A3 (en) Pretreatment of plastic materials for metal plating
PT885881E (pt) Acidos sulfonilalcanoilamino hidroxietilamino sulfamicos uteis como inibidores de protease retroviral
BR9815177B1 (pt) mÉtodo para tratamento de uma superfÍcie pintada e composiÇço de prÉ-revestimento.
UY25321A1 (es) Combinaciones de inhibidor de ace-inhibidor de mmp
BR9000010A (pt) Composicao detergente liquida enzimatica
ES2179414T3 (es) Procedimiento mejorado de estabilizacion de proteinas.
ES2063113T3 (es) Polipeptidos de veneno de vibora y expresion genetica.
ATE48281T1 (de) Citronensaeureester als treibmittel zur kunststoffverarbeitung.
AR013618A1 (es) Metodo y composiciones para la distribucion y expresion de acidos nucleicos de interferon
BR0009396A (pt) Lipase, composição detergente, sequência de dna, vetor de expressão, célula hospedeira transformada, e, processo para produzir a lipase
ES2062282T3 (es) Proceso de racemizacion de esteres del acido carboxilico opticamente activos.
ES2149244T3 (es) Procedimientos para producir proteina c.
ES2060202T3 (es) Composicion detergente enzimatica liquida.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees