MX394262B - Uso de sintasas de octacetido para producir acido kermesico y acido flavokermesico. - Google Patents
Uso de sintasas de octacetido para producir acido kermesico y acido flavokermesico.Info
- Publication number
- MX394262B MX394262B MX2017015889A MX2017015889A MX394262B MX 394262 B MX394262 B MX 394262B MX 2017015889 A MX2017015889 A MX 2017015889A MX 2017015889 A MX2017015889 A MX 2017015889A MX 394262 B MX394262 B MX 394262B
- Authority
- MX
- Mexico
- Prior art keywords
- acid
- synthase
- sub
- octaketide
- octacetide
- Prior art date
Links
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 title 1
- DDTNCHWMNZLWKO-UHFFFAOYSA-N laccaic acid D Chemical compound O=C1C2=CC(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C DDTNCHWMNZLWKO-UHFFFAOYSA-N 0.000 title 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 2
- DGQLVPJVXFOQEV-NGOCYOHBSA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-NGOCYOHBSA-N 0.000 abstract 2
- 229940114118 carminic acid Drugs 0.000 abstract 2
- 235000012730 carminic acid Nutrition 0.000 abstract 2
- 239000004106 carminic acid Substances 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 108010030975 Polyketide Synthases Proteins 0.000 abstract 1
- 108010060641 flavanone synthetase Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un método para producir un compuesto aromático derivado de octacétido, en el que el método está caracterizado porque comprende: (I) contactar in vitro en una célula huésped recombinante que comprende un gen de policétido sintasa de Tipo III (PKS) introducido recombinantemente que codifica un octacético sintasa (OKS) y en el que OKS es de un género diferente al de la célula huésped: (i) unidad de inicio y unidades extensoras adecuadas con el OKS introducido recombinante capaz de convertir las unidades de inicio y extensoras en un cotacétido no reducido en condiciones adecuadas en las que se produce in vivo el octacétido no reducido; y (II): convertir in vivo dentro de la célula huésped recombinante el octacétido no reducido de la etpa (I) en un compuesto de aglicón aromático C14-C34 mediante la participación de por lo menos una aromatasa/ciclasa que actúa in trans, en donde el compuesto de aglicón aromático de interés no es SEK4 y/o SER4B; (III): la célula huésped recombinante además comprende un gen de glicosiltransferasa que codifica una glicosiltransferasa que tiene al menos 90% de identidad de SEQ ID NO: 2 o los aminoácidos 1 a 468 de SEQ ID NO: 2, el cual glocosila el compuesto de aglicón aromático producido en la etapa (II) en el compuesto de glicósido aromático C14-C34; y (IV): aislar el compuesto de aglicón aromático de la etapa (III) para obtener una composición, en donde la composición comprende menos de 1% peso /peso de materia seca de material de célula huésped recombinante, y en donde la célula huésped recombinante es una célula vegetal o una célula fúngica filamentosa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15171375 | 2015-06-10 | ||
| PCT/EP2016/063242 WO2016198564A1 (en) | 2015-06-10 | 2016-06-10 | Use of octaketide synthases to produce kermesic acid and flavokermesic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017015889A MX2017015889A (es) | 2018-08-09 |
| MX394262B true MX394262B (es) | 2025-03-24 |
Family
ID=53373335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017015889A MX394262B (es) | 2015-06-10 | 2016-06-10 | Uso de sintasas de octacetido para producir acido kermesico y acido flavokermesico. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10415066B2 (es) |
| EP (1) | EP3307899A1 (es) |
| CN (1) | CN108026547A (es) |
| AU (1) | AU2016277469B2 (es) |
| BR (1) | BR112017026570A8 (es) |
| CO (1) | CO2017012691A2 (es) |
| EA (1) | EA038136B1 (es) |
| MX (1) | MX394262B (es) |
| PE (1) | PE20180674A1 (es) |
| WO (1) | WO2016198564A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106062186A (zh) * | 2013-12-18 | 2016-10-26 | 哥本哈根大学 | 糖基化黄胭脂酮酸和/或胭脂酮酸的糖基转移酶 |
| CN107345210A (zh) * | 2017-06-26 | 2017-11-14 | 江苏师范大学 | 一株呋喃香豆素基因转化的杀虫工程菌株及其应用 |
| WO2019241322A1 (en) * | 2018-06-13 | 2019-12-19 | Manus Bio, Inc. | Enzymes, methods, and host cells for producing carminic acid |
| WO2020161354A1 (en) | 2019-02-08 | 2020-08-13 | Pili | Recombinant host cells to produce anthraquinone derivatives |
| MX2020007632A (es) * | 2020-07-16 | 2022-01-17 | Carinlab S A P I De C V | Pprocedimiento para obtencion de acido carminico. |
| CN111979209A (zh) * | 2020-08-24 | 2020-11-24 | 中国科学院大学 | 一种聚八酮合酶及其编码基因与应用 |
| CN111979134B (zh) * | 2020-08-28 | 2022-02-15 | 江南大学 | 一种合成胭脂红酸的重组酿酒酵母的构建及其应用 |
| CN113621526B (zh) * | 2021-09-07 | 2023-06-02 | 鲁东大学 | 一种海洋真菌杂色曲霉m-7-sw9、混源萜类化合物及其提取方法和应用 |
| KR102768681B1 (ko) | 2022-03-10 | 2025-02-20 | 엔젯 주식회사 | 적층 조형 시스템 및 적층 조형하는 방법 |
| CN117586349B (zh) * | 2024-01-19 | 2024-04-05 | 齐齐哈尔大学 | 玉米谷蛋白源抗氧化活性肽及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001664A1 (en) | 1990-07-17 | 1992-02-06 | European Colour Plc | Synthesis of carminic acid and principal intermediates |
| EP1059354A2 (en) * | 1999-06-10 | 2000-12-13 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
| BR0014455A (pt) * | 1999-10-01 | 2002-06-11 | Basf Ag | Sequência de dna, proteìna, uso de uma sequência de dna, métodos para encontrar substâncias, para identificar substâncias com ação herbicida e para eliminar crescimento de plantas indesejadas, sistema de teste, e, inibidor |
| DK1649029T3 (en) | 2003-06-19 | 2015-03-09 | Evolva Sa | PROCEDURE FOR PREPARING A LOW MOLECULAR WEIGHT SECONDARY PLANT METABOLITE IN A YARCELL |
| EP1669414B1 (en) | 2004-11-25 | 2010-05-26 | Chr. Hansen A/S | Method for the preparation of a carminic acid lake |
-
2016
- 2016-06-10 PE PE2017002548A patent/PE20180674A1/es unknown
- 2016-06-10 BR BR112017026570A patent/BR112017026570A8/pt not_active Application Discontinuation
- 2016-06-10 AU AU2016277469A patent/AU2016277469B2/en not_active Ceased
- 2016-06-10 WO PCT/EP2016/063242 patent/WO2016198564A1/en not_active Ceased
- 2016-06-10 CN CN201680046698.8A patent/CN108026547A/zh active Pending
- 2016-06-10 MX MX2017015889A patent/MX394262B/es unknown
- 2016-06-10 EA EA201792684A patent/EA038136B1/ru unknown
- 2016-06-10 US US15/735,051 patent/US10415066B2/en active Active
- 2016-06-10 EP EP16732500.0A patent/EP3307899A1/en active Pending
-
2017
- 2017-12-11 CO CONC2017/0012691A patent/CO2017012691A2/es unknown
-
2019
- 2019-07-09 US US16/506,256 patent/US10900056B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017015889A (es) | 2018-08-09 |
| US10900056B2 (en) | 2021-01-26 |
| CO2017012691A2 (es) | 2020-04-13 |
| PE20180674A1 (es) | 2018-04-19 |
| US20200040367A1 (en) | 2020-02-06 |
| US20190127767A1 (en) | 2019-05-02 |
| BR112017026570A8 (pt) | 2023-01-10 |
| EP3307899A1 (en) | 2018-04-18 |
| BR112017026570A2 (pt) | 2018-08-14 |
| EA201792684A1 (ru) | 2018-06-29 |
| CN108026547A (zh) | 2018-05-11 |
| US10415066B2 (en) | 2019-09-17 |
| AU2016277469B2 (en) | 2021-06-24 |
| EA038136B1 (ru) | 2021-07-12 |
| AU2016277469A1 (en) | 2017-12-21 |
| WO2016198564A1 (en) | 2016-12-15 |
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