BR112017026570A8 - Método para produção de um composto aromático derivado de octacetídeo de interesse - Google Patents
Método para produção de um composto aromático derivado de octacetídeo de interesseInfo
- Publication number
- BR112017026570A8 BR112017026570A8 BR112017026570A BR112017026570A BR112017026570A8 BR 112017026570 A8 BR112017026570 A8 BR 112017026570A8 BR 112017026570 A BR112017026570 A BR 112017026570A BR 112017026570 A BR112017026570 A BR 112017026570A BR 112017026570 A8 BR112017026570 A8 BR 112017026570A8
- Authority
- BR
- Brazil
- Prior art keywords
- octacetide
- interest
- aromatic compound
- production
- unreduced
- Prior art date
Links
- 150000001491 aromatic compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- DGQLVPJVXFOQEV-NGOCYOHBSA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-NGOCYOHBSA-N 0.000 abstract 2
- 229940114118 carminic acid Drugs 0.000 abstract 2
- 235000012730 carminic acid Nutrition 0.000 abstract 2
- 239000004106 carminic acid Substances 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 108010030975 Polyketide Synthases Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
MÉTODO PARA PRODUÇÃO DE UM COMPOSTO AROMÁTICO DERIVADO DE OCTACETÍDEO DE INTERESSE. A presente invenção refere-se a um método para produção de um composto aromático derivado de octacetídeo de interesse (por exemplo, ácido carmínico), em que o método compreende (I): expressão heteróloga de um gene de sintase de policetídeo (PKS) Tipo III recombinantemente introduzido que codifica uma sintase de octacetídeo (OKS) para obter octacetídeo não reduzido in vivo na célula hospedeira recombinante e (II): conversão in vivo do octacetídeo não reduzido da etapa (I) em um composto aromático C14-C34 de interesse (por exemplo, ácido carmínico).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15171375 | 2015-06-10 | ||
| PCT/EP2016/063242 WO2016198564A1 (en) | 2015-06-10 | 2016-06-10 | Use of octaketide synthases to produce kermesic acid and flavokermesic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017026570A2 BR112017026570A2 (pt) | 2018-08-14 |
| BR112017026570A8 true BR112017026570A8 (pt) | 2023-01-10 |
Family
ID=53373335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017026570A BR112017026570A8 (pt) | 2015-06-10 | 2016-06-10 | Método para produção de um composto aromático derivado de octacetídeo de interesse |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10415066B2 (pt) |
| EP (1) | EP3307899A1 (pt) |
| CN (1) | CN108026547A (pt) |
| AU (1) | AU2016277469B2 (pt) |
| BR (1) | BR112017026570A8 (pt) |
| CO (1) | CO2017012691A2 (pt) |
| EA (1) | EA038136B1 (pt) |
| MX (1) | MX2017015889A (pt) |
| PE (1) | PE20180674A1 (pt) |
| WO (1) | WO2016198564A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2660301T3 (es) | 2013-12-18 | 2018-03-21 | Københavns Universitet | Glicosiltransferasa que glicosila ácido flavokermésico y/o ácido kermésico |
| CN107345210A (zh) * | 2017-06-26 | 2017-11-14 | 江苏师范大学 | 一株呋喃香豆素基因转化的杀虫工程菌株及其应用 |
| WO2019241322A1 (en) * | 2018-06-13 | 2019-12-19 | Manus Bio, Inc. | Enzymes, methods, and host cells for producing carminic acid |
| WO2020161354A1 (en) | 2019-02-08 | 2020-08-13 | Pili | Recombinant host cells to produce anthraquinone derivatives |
| MX2020007632A (es) * | 2020-07-16 | 2022-01-17 | Carinlab S A P I De C V | Pprocedimiento para obtencion de acido carminico. |
| CN111979209A (zh) * | 2020-08-24 | 2020-11-24 | 中国科学院大学 | 一种聚八酮合酶及其编码基因与应用 |
| CN111979134B (zh) * | 2020-08-28 | 2022-02-15 | 江南大学 | 一种合成胭脂红酸的重组酿酒酵母的构建及其应用 |
| CN113621526B (zh) * | 2021-09-07 | 2023-06-02 | 鲁东大学 | 一种海洋真菌杂色曲霉m-7-sw9、混源萜类化合物及其提取方法和应用 |
| KR20230134396A (ko) | 2022-03-10 | 2023-09-21 | 엔젯 주식회사 | 적층 조형 시스템 및 적층 조형하는 방법 |
| CN117586349B (zh) * | 2024-01-19 | 2024-04-05 | 齐齐哈尔大学 | 玉米谷蛋白源抗氧化活性肽及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE136019T1 (de) | 1990-07-17 | 1996-04-15 | Europ Colour Plc | Synthese von karminsäure und hauptzwischenprodukten |
| EP1059354A2 (en) * | 1999-06-10 | 2000-12-13 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
| CA2385875A1 (en) * | 1999-10-01 | 2001-04-12 | Basf Aktiengesellschaft | Gmp synthetase derived from plants |
| WO2004111254A1 (en) | 2003-06-19 | 2004-12-23 | Poalis A/S | A method of producing a low molecular weight organic compound in a cell |
| EP1669414B1 (en) | 2004-11-25 | 2010-05-26 | Chr. Hansen A/S | Method for the preparation of a carminic acid lake |
-
2016
- 2016-06-10 EP EP16732500.0A patent/EP3307899A1/en active Pending
- 2016-06-10 BR BR112017026570A patent/BR112017026570A8/pt not_active Application Discontinuation
- 2016-06-10 AU AU2016277469A patent/AU2016277469B2/en active Active
- 2016-06-10 EA EA201792684A patent/EA038136B1/ru unknown
- 2016-06-10 PE PE2017002548A patent/PE20180674A1/es unknown
- 2016-06-10 CN CN201680046698.8A patent/CN108026547A/zh active Pending
- 2016-06-10 US US15/735,051 patent/US10415066B2/en active Active
- 2016-06-10 WO PCT/EP2016/063242 patent/WO2016198564A1/en active Application Filing
- 2016-06-10 MX MX2017015889A patent/MX2017015889A/es unknown
-
2017
- 2017-12-11 CO CONC2017/0012691A patent/CO2017012691A2/es unknown
-
2019
- 2019-07-09 US US16/506,256 patent/US10900056B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201792684A1 (ru) | 2018-06-29 |
| CO2017012691A2 (es) | 2020-04-13 |
| EA038136B1 (ru) | 2021-07-12 |
| AU2016277469B2 (en) | 2021-06-24 |
| AU2016277469A1 (en) | 2017-12-21 |
| MX2017015889A (es) | 2018-08-09 |
| WO2016198564A1 (en) | 2016-12-15 |
| EP3307899A1 (en) | 2018-04-18 |
| US10415066B2 (en) | 2019-09-17 |
| US20200040367A1 (en) | 2020-02-06 |
| US10900056B2 (en) | 2021-01-26 |
| BR112017026570A2 (pt) | 2018-08-14 |
| PE20180674A1 (es) | 2018-04-19 |
| CN108026547A (zh) | 2018-05-11 |
| US20190127767A1 (en) | 2019-05-02 |
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Legal Events
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| B25A | Requested transfer of rights approved |
Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK) |
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| B25G | Requested change of headquarter approved |
Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK) |
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| B25K | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication |
Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK) Free format text: RETIFICACAO DO DESPACHO (25.7) ? ALTERACAO DE SEDE PUBLICADO NA RPI NO 2649, DE 13/10/2021, QUANTO AO ITEM (71) - DEPOSITANTE.ONDE SE LE: DANMARKS TEKNISKE UNIVERSITET (DK), KOEBENHAVNS UNIVERSITET (DK)LEIA-SE: DANMARKS TEKNISKE UNIVERSITET (DK), KOEBENHAVNS UNIVERSITET (DK) E CHR. HANSEN NATURAL COLORS A/S (DK) |
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| B25D | Requested change of name of applicant approved |
Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; OTERRA A/S (DK) |
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| B25G | Requested change of headquarter approved |
Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; OTERRA A/S (DK) |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |