CO2017012691A2 - Método para producir compuestos aromáticos derivados de octacétidos - Google Patents

Método para producir compuestos aromáticos derivados de octacétidos

Info

Publication number
CO2017012691A2
CO2017012691A2 CONC2017/0012691A CO2017012691A CO2017012691A2 CO 2017012691 A2 CO2017012691 A2 CO 2017012691A2 CO 2017012691 A CO2017012691 A CO 2017012691A CO 2017012691 A2 CO2017012691 A2 CO 2017012691A2
Authority
CO
Colombia
Prior art keywords
octacetide
octacetides
aromatic compounds
compounds derived
produce aromatic
Prior art date
Application number
CONC2017/0012691A
Other languages
English (en)
Inventor
Birger Lindberg Møller
Bjørn Madsen
Dan Stærk
Finn Thyge Okkels
Johan Andersen-Ranberg
Kenneth Thermann Kongstad
Kim Binderup
Mads Bennedsen
Majse Nafisi
Paiman Khorsand-Jamal
Rubini Maya Kannangara
Uffe Hasbro Mortensen
Ulf Thrane
Rasmus John Normand Frandsen
Original Assignee
Univ Danmarks Tekniske
Univ Copenhagen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Danmarks Tekniske, Univ Copenhagen filed Critical Univ Danmarks Tekniske
Publication of CO2017012691A2 publication Critical patent/CO2017012691A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Un método para producir un compuesto aromático derivado de octacétido de interés (por ejemplo, ácido carmínico), en el que el método comprende (I): la expresión heteróloga de un gen de policétido sintasa (PKS) de tipo III introducido recombinantemente que codifica un octacétido sintasa (OKS) para obtener un octacétido no reducido in vivo dentro de la célula huésped recombinante y (II): convertir in vivo el octacétido no reducido de la etapa (I) en un compuesto aromático C14-C34 de interés (por ejemplo, ácido carmínico).
CONC2017/0012691A 2015-06-10 2017-12-11 Método para producir compuestos aromáticos derivados de octacétidos CO2017012691A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15171375 2015-06-10
PCT/EP2016/063242 WO2016198564A1 (en) 2015-06-10 2016-06-10 Use of octaketide synthases to produce kermesic acid and flavokermesic acid

Publications (1)

Publication Number Publication Date
CO2017012691A2 true CO2017012691A2 (es) 2020-04-13

Family

ID=53373335

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0012691A CO2017012691A2 (es) 2015-06-10 2017-12-11 Método para producir compuestos aromáticos derivados de octacétidos

Country Status (10)

Country Link
US (2) US10415066B2 (es)
EP (1) EP3307899A1 (es)
CN (1) CN108026547A (es)
AU (1) AU2016277469B2 (es)
BR (1) BR112017026570A8 (es)
CO (1) CO2017012691A2 (es)
EA (1) EA038136B1 (es)
MX (1) MX2017015889A (es)
PE (1) PE20180674A1 (es)
WO (1) WO2016198564A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201802540T4 (tr) 2013-12-18 2018-03-21 Univ Copenhagen Flavokermesik asit ve/veya kermesik asidi glikosile eden glikosiltransferaz.
CN107345210A (zh) * 2017-06-26 2017-11-14 江苏师范大学 一株呋喃香豆素基因转化的杀虫工程菌株及其应用
US20210261992A1 (en) * 2018-06-13 2021-08-26 Manus Bio, Inc. Enzymes, methods, and host cells for producing carminic acid
WO2020161354A1 (en) 2019-02-08 2020-08-13 Pili Recombinant host cells to produce anthraquinone derivatives
MX2020007632A (es) * 2020-07-16 2022-01-17 Carinlab S A P I De C V Pprocedimiento para obtencion de acido carminico.
CN111979209A (zh) * 2020-08-24 2020-11-24 中国科学院大学 一种聚八酮合酶及其编码基因与应用
CN111979134B (zh) * 2020-08-28 2022-02-15 江南大学 一种合成胭脂红酸的重组酿酒酵母的构建及其应用
CN113621526B (zh) * 2021-09-07 2023-06-02 鲁东大学 一种海洋真菌杂色曲霉m-7-sw9、混源萜类化合物及其提取方法和应用
KR20230134396A (ko) 2022-03-10 2023-09-21 엔젯 주식회사 적층 조형 시스템 및 적층 조형하는 방법
CN117586349B (zh) * 2024-01-19 2024-04-05 齐齐哈尔大学 玉米谷蛋白源抗氧化活性肽及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8295591A (en) 1990-07-17 1992-02-18 European Colour Plc Synthesis of carminic acid and principal intermediates
EP1059354A2 (en) * 1999-06-10 2000-12-13 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
EP1222293A2 (de) * 1999-10-01 2002-07-17 Basf Aktiengesellschaft Gmp-synthetase aus pflanzen
EP1649029B1 (en) 2003-06-19 2014-12-17 Evolva SA A method of producing a low molecular weight plant secondary metabolite in a yeast cell
ATE469191T1 (de) 2004-11-25 2010-06-15 Chr Hansen As Verfahren zur herstellung eines karminsaürelackes

Also Published As

Publication number Publication date
MX2017015889A (es) 2018-08-09
US10415066B2 (en) 2019-09-17
BR112017026570A2 (pt) 2018-08-14
BR112017026570A8 (pt) 2023-01-10
EP3307899A1 (en) 2018-04-18
WO2016198564A1 (en) 2016-12-15
CN108026547A (zh) 2018-05-11
EA038136B1 (ru) 2021-07-12
US20200040367A1 (en) 2020-02-06
AU2016277469B2 (en) 2021-06-24
EA201792684A1 (ru) 2018-06-29
PE20180674A1 (es) 2018-04-19
AU2016277469A1 (en) 2017-12-21
US20190127767A1 (en) 2019-05-02
US10900056B2 (en) 2021-01-26

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