BR112017026570A2 - método para produção de um composto aromático derivado de octacetídeo de interesse - Google Patents

método para produção de um composto aromático derivado de octacetídeo de interesse

Info

Publication number
BR112017026570A2
BR112017026570A2 BR112017026570A BR112017026570A BR112017026570A2 BR 112017026570 A2 BR112017026570 A2 BR 112017026570A2 BR 112017026570 A BR112017026570 A BR 112017026570A BR 112017026570 A BR112017026570 A BR 112017026570A BR 112017026570 A2 BR112017026570 A2 BR 112017026570A2
Authority
BR
Brazil
Prior art keywords
octacetide
interest
aromatic compound
producing
derived aromatic
Prior art date
Application number
BR112017026570A
Other languages
English (en)
Other versions
BR112017026570A8 (pt
Inventor
Lindberg Møller Birger
Madsen Bjørn
Stærk Dan
Thyge Okkels Finn
Andersen-Ranberg Johan
Thermann Kongstad Kenneth
Binderup Kim
Bennedsen Mads
Nafisi Majse
Khorsand-Jamal Paiman
Maya Kannangara Rubini
Hasbro Mortensen Uffe
Thrane Ulf
John Normand Frandsen Rasmus
Original Assignee
Danmarks Tekniske Universitet
Københavns Universitet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danmarks Tekniske Universitet, Københavns Universitet filed Critical Danmarks Tekniske Universitet
Publication of BR112017026570A2 publication Critical patent/BR112017026570A2/pt
Publication of BR112017026570A8 publication Critical patent/BR112017026570A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção refere-se a um método para produção de um composto aromático derivado de octacetídeo de interesse (por exemplo, ácido carmínico), em que o método compreende (i): expressão heteróloga de um gene de sintase de policetídeo (pks) tipo iii recombinantemente introduzido que codifica uma sintase de octacetídeo (oks) para obter octacetídeo não reduzido in vivo na célula hospedeira recombinante e (ii): conversão in vivo do octacetídeo não reduzido da etapa (i) em um composto aromático c14-c34 de interesse (por exemplo, ácido carmínico).
BR112017026570A 2015-06-10 2016-06-10 Método para produção de um composto aromático derivado de octacetídeo de interesse BR112017026570A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15171375 2015-06-10
PCT/EP2016/063242 WO2016198564A1 (en) 2015-06-10 2016-06-10 Use of octaketide synthases to produce kermesic acid and flavokermesic acid

Publications (2)

Publication Number Publication Date
BR112017026570A2 true BR112017026570A2 (pt) 2018-08-14
BR112017026570A8 BR112017026570A8 (pt) 2023-01-10

Family

ID=53373335

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017026570A BR112017026570A8 (pt) 2015-06-10 2016-06-10 Método para produção de um composto aromático derivado de octacetídeo de interesse

Country Status (10)

Country Link
US (2) US10415066B2 (pt)
EP (1) EP3307899A1 (pt)
CN (1) CN108026547A (pt)
AU (1) AU2016277469B2 (pt)
BR (1) BR112017026570A8 (pt)
CO (1) CO2017012691A2 (pt)
EA (1) EA038136B1 (pt)
MX (1) MX2017015889A (pt)
PE (1) PE20180674A1 (pt)
WO (1) WO2016198564A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201802540T4 (tr) 2013-12-18 2018-03-21 Univ Copenhagen Flavokermesik asit ve/veya kermesik asidi glikosile eden glikosiltransferaz.
CN107345210A (zh) * 2017-06-26 2017-11-14 江苏师范大学 一株呋喃香豆素基因转化的杀虫工程菌株及其应用
WO2019241322A1 (en) * 2018-06-13 2019-12-19 Manus Bio, Inc. Enzymes, methods, and host cells for producing carminic acid
WO2020161354A1 (en) 2019-02-08 2020-08-13 Pili Recombinant host cells to produce anthraquinone derivatives
MX2020007632A (es) * 2020-07-16 2022-01-17 Carinlab S A P I De C V Pprocedimiento para obtencion de acido carminico.
CN111979209A (zh) * 2020-08-24 2020-11-24 中国科学院大学 一种聚八酮合酶及其编码基因与应用
CN111979134B (zh) * 2020-08-28 2022-02-15 江南大学 一种合成胭脂红酸的重组酿酒酵母的构建及其应用
CN113621526B (zh) * 2021-09-07 2023-06-02 鲁东大学 一种海洋真菌杂色曲霉m-7-sw9、混源萜类化合物及其提取方法和应用
KR20230134396A (ko) 2022-03-10 2023-09-21 엔젯 주식회사 적층 조형 시스템 및 적층 조형하는 방법
CN117586349B (zh) * 2024-01-19 2024-04-05 齐齐哈尔大学 玉米谷蛋白源抗氧化活性肽及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69118405D1 (de) 1990-07-17 1996-05-02 Europ Colour Plc Synthese von karminsäure und hauptzwischenprodukten
EP1059354A2 (en) * 1999-06-10 2000-12-13 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
EP1222293A2 (de) * 1999-10-01 2002-07-17 Basf Aktiengesellschaft Gmp-synthetase aus pflanzen
EP1649029B1 (en) 2003-06-19 2014-12-17 Evolva SA A method of producing a low molecular weight plant secondary metabolite in a yeast cell
ATE469191T1 (de) 2004-11-25 2010-06-15 Chr Hansen As Verfahren zur herstellung eines karminsaürelackes

Also Published As

Publication number Publication date
MX2017015889A (es) 2018-08-09
US10900056B2 (en) 2021-01-26
PE20180674A1 (es) 2018-04-19
BR112017026570A8 (pt) 2023-01-10
US20190127767A1 (en) 2019-05-02
CO2017012691A2 (es) 2020-04-13
EP3307899A1 (en) 2018-04-18
AU2016277469A1 (en) 2017-12-21
US20200040367A1 (en) 2020-02-06
EA201792684A1 (ru) 2018-06-29
AU2016277469B2 (en) 2021-06-24
CN108026547A (zh) 2018-05-11
WO2016198564A1 (en) 2016-12-15
EA038136B1 (ru) 2021-07-12
US10415066B2 (en) 2019-09-17

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK)

B25G Requested change of headquarter approved

Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK)

B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK)

Free format text: RETIFICACAO DO DESPACHO (25.7) ? ALTERACAO DE SEDE PUBLICADO NA RPI NO 2649, DE 13/10/2021, QUANTO AO ITEM (71) - DEPOSITANTE.ONDE SE LE: DANMARKS TEKNISKE UNIVERSITET (DK), KOEBENHAVNS UNIVERSITET (DK)LEIA-SE: DANMARKS TEKNISKE UNIVERSITET (DK), KOEBENHAVNS UNIVERSITET (DK) E CHR. HANSEN NATURAL COLORS A/S (DK)

B25D Requested change of name of applicant approved

Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; OTERRA A/S (DK)

B25G Requested change of headquarter approved

Owner name: KOEBENHAVNS UNIVERSITET (DK) ; DANMARKS TEKNISKE UNIVERSITET (DK) ; OTERRA A/S (DK)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]