MX381489B - Compuesto biciclico y uso del mismo para la inhibicion de suv39h2. - Google Patents

Compuesto biciclico y uso del mismo para la inhibicion de suv39h2.

Info

Publication number
MX381489B
MX381489B MX2018003903A MX2018003903A MX381489B MX 381489 B MX381489 B MX 381489B MX 2018003903 A MX2018003903 A MX 2018003903A MX 2018003903 A MX2018003903 A MX 2018003903A MX 381489 B MX381489 B MX 381489B
Authority
MX
Mexico
Prior art keywords
suv39h2
inhibition
bicyclic compound
bicyclic
compound
Prior art date
Application number
MX2018003903A
Other languages
English (en)
Other versions
MX2018003903A (es
Inventor
Arvapalli Venkata Satyanarayana
Anjan Chakrabarti
Shoji Hisada
Hélène Decornez
Yo Matsuo
Manish Rawat
Yusuke Nakamura
Sanjay Rai
Srinivas Ravula
Arindam Talukdar
Zhiyong Duan
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of MX2018003903A publication Critical patent/MX2018003903A/es
Publication of MX381489B publication Critical patent/MX381489B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a un compuesto representado por la fórmula (I). (ver Fórmula).
MX2018003903A 2015-09-29 2016-09-12 Compuesto biciclico y uso del mismo para la inhibicion de suv39h2. MX381489B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562234183P 2015-09-29 2015-09-29
PCT/US2016/051350 WO2017058503A1 (en) 2015-09-29 2016-09-12 Bicyclic compound and use thereof for inhibiting suv39h2

Publications (2)

Publication Number Publication Date
MX2018003903A MX2018003903A (es) 2018-09-21
MX381489B true MX381489B (es) 2025-03-12

Family

ID=58427860

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003903A MX381489B (es) 2015-09-29 2016-09-12 Compuesto biciclico y uso del mismo para la inhibicion de suv39h2.

Country Status (16)

Country Link
US (1) US10508109B2 (es)
EP (1) EP3355699B1 (es)
JP (1) JP6827621B2 (es)
KR (1) KR20180082432A (es)
CN (1) CN108135175B (es)
AU (2) AU2016332021A1 (es)
BR (1) BR112018006005A2 (es)
CA (1) CA2999852A1 (es)
DK (1) DK3355699T3 (es)
ES (1) ES2874089T3 (es)
IL (1) IL258328B (es)
MX (1) MX381489B (es)
RU (1) RU2729187C1 (es)
SG (1) SG10202002831RA (es)
TW (1) TWI696622B (es)
WO (1) WO2017058503A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115702149B (zh) * 2020-04-30 2025-08-19 先正达农作物保护股份公司 具有含硫取代基的杀有害生物活性的杂环衍生物
AR123281A1 (es) * 2020-08-19 2022-11-16 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como inhibidores de tlr9
CN113304151B (zh) * 2021-04-15 2022-05-03 中山大学 一种硝基呋喃类小分子化合物在制备诱导铁死亡和/或减缓胃癌化疗耐药药物中的应用
AR134414A1 (es) * 2023-11-21 2026-01-14 Novartis Ag Imidazoarenos sustituidos y métodos para su uso
CN117924279B (zh) * 2024-03-18 2024-07-16 中山大学 一种melk抑制剂及其应用

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MC1673A1 (fr) * 1984-06-27 1986-06-03 Wellcome Found Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments
JP4041624B2 (ja) * 1999-07-21 2008-01-30 三井化学株式会社 有機電界発光素子
US6596731B2 (en) * 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
US20060194199A1 (en) 2002-09-30 2006-08-31 Oncotherapy Science, Inc. Method for diagnosing testicular seminomas
WO2005060571A2 (en) * 2003-12-10 2005-07-07 Merck & Co., Inc. Antiprotozoal imidazopyridine compounds
TWI350373B (en) 2004-01-23 2011-10-11 Oncotherapy Science Inc Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators
US8053183B2 (en) 2005-07-27 2011-11-08 Oncotherapy Science, Inc. Method of diagnosing esophageal cancer
AU2008314871A1 (en) * 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
ES2637794T3 (es) * 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
KR101492308B1 (ko) * 2008-05-14 2015-02-11 가부시키가이샤 오츠까 세이야꾸 고죠 벤젠 유도체를 포함하는 지단백 지방 분해 효소 활성화 조성물
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
EP2649062B1 (en) 2010-11-30 2015-04-08 Takeda Pharmaceutical Company Limited Bicyclic compounds as inhibitors of acetyl-coa carboxylase (acc)
US8975276B2 (en) * 2011-06-29 2015-03-10 Bristol-Myers Squibb Company Inhibitors of PDE10
RU2015147450A (ru) 2013-04-29 2017-06-05 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ 2-ФЕНИЛ ИЛИ 2-ГЕТЕРОАРИЛ ИМИДАЗОЛ[1,2-a]ПИРИДИНА
DK2991984T3 (en) * 2013-04-30 2017-05-08 Hoffmann La Roche PALLADIUM-CATALYST COUPLING OF PYRAZOLAMIDES
ES2629389T3 (es) * 2013-05-23 2017-08-09 H. Hoffnabb-La Roche Ag 2-fenilimidazo[1,2-a]pirimidinas como agentes de obtención de imágenes
WO2014187922A1 (en) * 2013-05-24 2014-11-27 Iomet Pharma Ltd. Slc2a transporter inhibitors
MX2015017821A (es) * 2013-07-02 2016-04-15 Syngenta Participations Ag Heterociclos bi-o triciclicos activos como plaguicidas con sustituyentes que contienen azufre.
JP6182668B2 (ja) * 2013-09-26 2017-08-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン
US10435401B2 (en) * 2014-09-16 2019-10-08 Syngenta Participations Ag Pesticidally active tetracyclic derivatives with sulphur containing substituents

Also Published As

Publication number Publication date
IL258328B (en) 2021-05-31
EP3355699A1 (en) 2018-08-08
SG10202002831RA (en) 2020-05-28
US20180273529A1 (en) 2018-09-27
AU2016332021A1 (en) 2018-04-19
MX2018003903A (es) 2018-09-21
CA2999852A1 (en) 2017-04-06
CN108135175A (zh) 2018-06-08
WO2017058503A1 (en) 2017-04-06
KR20180082432A (ko) 2018-07-18
EP3355699B1 (en) 2021-03-31
TWI696622B (zh) 2020-06-21
BR112018006005A2 (pt) 2018-10-30
CN108135175B (zh) 2021-04-06
AU2021201573A1 (en) 2021-04-01
IL258328A (en) 2018-05-31
HK1252428A1 (en) 2019-05-24
US10508109B2 (en) 2019-12-17
EP3355699A4 (en) 2019-06-19
JP6827621B2 (ja) 2021-02-10
RU2729187C1 (ru) 2020-08-05
JP2018531244A (ja) 2018-10-25
ES2874089T3 (es) 2021-11-04
AU2021201573B2 (en) 2022-02-17
TW201718580A (zh) 2017-06-01
DK3355699T3 (da) 2021-06-07

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