MX380868B - Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. - Google Patents
Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario.Info
- Publication number
- MX380868B MX380868B MX2016016136A MX2016016136A MX380868B MX 380868 B MX380868 B MX 380868B MX 2016016136 A MX2016016136 A MX 2016016136A MX 2016016136 A MX2016016136 A MX 2016016136A MX 380868 B MX380868 B MX 380868B
- Authority
- MX
- Mexico
- Prior art keywords
- sleep
- increase
- subject
- methods
- reduce
- Prior art date
Links
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title abstract 3
- 230000009478 tonic inhibition Effects 0.000 title abstract 3
- 230000007958 sleep Effects 0.000 abstract 6
- 230000037053 non-rapid eye movement Effects 0.000 abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 230000037046 slow wave activity Effects 0.000 abstract 2
- 230000037322 slow-wave sleep Effects 0.000 abstract 2
- ZDZDSZQYRBZPNN-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate;hydrochloride Chemical compound Cl.C1NCCC2=C1ONC2=O ZDZDSZQYRBZPNN-UHFFFAOYSA-N 0.000 abstract 1
- 208000009575 Angelman syndrome Diseases 0.000 abstract 1
- 208000001914 Fragile X syndrome Diseases 0.000 abstract 1
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004622 sleep time Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462008939P | 2014-06-06 | 2014-06-06 | |
| PCT/US2015/034018 WO2015187851A1 (en) | 2014-06-06 | 2015-06-03 | Methods of increasing tonic inhibition and treating secondary insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016016136A MX2016016136A (es) | 2017-07-05 |
| MX380868B true MX380868B (es) | 2025-03-12 |
Family
ID=54767324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016016136A MX380868B (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
| MX2020012404A MX391502B (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012404A MX391502B (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario |
Country Status (20)
| Country | Link |
|---|---|
| US (11) | US20150352085A1 (https=) |
| EP (3) | EP3151832B1 (https=) |
| JP (4) | JP2017516868A (https=) |
| AR (1) | AR100772A1 (https=) |
| AU (4) | AU2015269667B2 (https=) |
| CA (1) | CA2950845C (https=) |
| CY (2) | CY1124368T1 (https=) |
| DK (2) | DK3151832T3 (https=) |
| ES (2) | ES2875742T3 (https=) |
| HR (2) | HRP20210901T1 (https=) |
| HU (2) | HUE055155T2 (https=) |
| IL (2) | IL249287B (https=) |
| LT (2) | LT3372229T (https=) |
| MX (2) | MX380868B (https=) |
| PL (2) | PL3372229T3 (https=) |
| PT (2) | PT3151832T (https=) |
| RS (2) | RS62006B1 (https=) |
| SI (2) | SI3372229T1 (https=) |
| SM (2) | SMT202100343T1 (https=) |
| WO (1) | WO2015187851A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3065782B8 (en) | 2013-11-05 | 2021-05-26 | Elena Molokanova | Nanostructure conjugates for modulation of location-specific subtypes of receptors and ion channels |
| DK3151832T3 (da) | 2014-06-06 | 2021-06-14 | Ovid Therapeutics Inc | Fremgangsmåder til øgning af tonisk hæmning og behandling af sekundær søvnløshed |
| US10434308B2 (en) | 2015-05-29 | 2019-10-08 | Medtronic, Inc. | Impedance matching and electrode conditioning in patient interface systems |
| US10080898B2 (en) * | 2015-05-29 | 2018-09-25 | Medtronic, Inc. | Simultaneous physiological sensing and stimulation with saturation detection |
| US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
| IL256912B2 (en) * | 2015-07-17 | 2024-01-01 | Ovid Therapeutics Inc | Methods of treating developmental disorders with gaboxadol |
| WO2018017639A1 (en) * | 2016-07-19 | 2018-01-25 | Georgia State University Research Foundation | Methods for treating rett syndrome |
| EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
| EP3528807A4 (en) * | 2016-11-22 | 2020-06-17 | Ovid Therapeutics Inc | METHOD FOR TREATING DEVELOPMENT DISORDERS AND / OR FALLS WITH FLUPIRTIN |
| US10071083B2 (en) * | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
| JP2020529440A (ja) | 2017-08-04 | 2020-10-08 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 糖尿病および関連する状態の処置におけるガボキサドールの使用 |
| US11181384B2 (en) * | 2018-07-23 | 2021-11-23 | Waymo Llc | Verifying map data using challenge questions |
| MX2021003302A (es) | 2018-09-20 | 2021-05-13 | Ovid Therapeutics Inc | Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez. |
| US11123332B2 (en) * | 2018-11-21 | 2021-09-21 | Certego Therapeutics Inc. | Gaboxadol for reducing risk of suicide and rapid relief of depression |
| EP3880201A4 (en) | 2018-12-17 | 2022-07-27 | Ovid Therapeutics Inc. | USE OF GABOXADOL IN THE TREATMENT OF NON-24 HOUR SLEEP waking disorder |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| KR20220035195A (ko) * | 2019-07-15 | 2022-03-21 | 오비드 테라퓨틱스 인크. | 치료적 치료를 위한 가복사돌을 포함하는 약학적 제제 |
| EP4051272A4 (en) | 2019-12-18 | 2023-01-04 | Ovid Therapeutics Inc. | GABOXADOL FOR THE THERAPEUTIC TREATMENT OF 1P36 DELETION SYNDROME |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
| JP7600661B2 (ja) * | 2020-12-11 | 2024-12-17 | ａｒｔｉｅｎｃｅ株式会社 | 貼付剤 |
| US20240285562A1 (en) * | 2023-02-17 | 2024-08-29 | Ovid Therapeutics Inc. | Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid in the treatment of multiple sclerosis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK270278A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| DE19526864A1 (de) | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
| US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| US6676961B1 (en) | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
| US20050137222A1 (en) * | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
| JP2007530604A (ja) | 2004-04-02 | 2007-11-01 | ハー・ルンドベック・アクチエゼルスカベット | 呼吸機能障害の治療 |
| DE102005020882A1 (de) * | 2005-05-04 | 2006-11-09 | Dömling, Alexander, Dr. | Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten |
| US20110046090A1 (en) * | 2005-10-31 | 2011-02-24 | Braincells Inc. | Modulation of neurogenesis with gaba agents and gaba analogs |
| US20090143335A1 (en) | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
| CA2705733C (en) | 2007-11-13 | 2015-02-03 | Cadence Pharmaceuticals | Reduced dose intravenous acetaminophen |
| CN102137667A (zh) * | 2008-09-01 | 2011-07-27 | H.隆德贝克有限公司 | 包含加波沙朵和patl或oat抑制剂的药物组合物 |
| DK3151832T3 (da) | 2014-06-06 | 2021-06-14 | Ovid Therapeutics Inc | Fremgangsmåder til øgning af tonisk hæmning og behandling af sekundær søvnløshed |
| IL256912B2 (en) * | 2015-07-17 | 2024-01-01 | Ovid Therapeutics Inc | Methods of treating developmental disorders with gaboxadol |
| US9399034B1 (en) | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
-
2015
- 2015-06-03 DK DK15803364.7T patent/DK3151832T3/da active
- 2015-06-03 RS RS20210711A patent/RS62006B1/sr unknown
- 2015-06-03 SI SI201531620T patent/SI3372229T1/sl unknown
- 2015-06-03 AU AU2015269667A patent/AU2015269667B2/en active Active
- 2015-06-03 MX MX2016016136A patent/MX380868B/es unknown
- 2015-06-03 EP EP15803364.7A patent/EP3151832B1/en active Active
- 2015-06-03 EP EP18169211.2A patent/EP3372229B1/en active Active
- 2015-06-03 LT LTEP18169211.2T patent/LT3372229T/lt unknown
- 2015-06-03 PT PT158033647T patent/PT3151832T/pt unknown
- 2015-06-03 ES ES18169211T patent/ES2875742T3/es active Active
- 2015-06-03 DK DK18169211.2T patent/DK3372229T3/da active
- 2015-06-03 CA CA2950845A patent/CA2950845C/en active Active
- 2015-06-03 PT PT181692112T patent/PT3372229T/pt unknown
- 2015-06-03 HU HUE15803364A patent/HUE055155T2/hu unknown
- 2015-06-03 SI SI201531616T patent/SI3151832T1/sl unknown
- 2015-06-03 PL PL18169211T patent/PL3372229T3/pl unknown
- 2015-06-03 RS RS20210718A patent/RS62007B1/sr unknown
- 2015-06-03 ES ES15803364T patent/ES2876350T3/es active Active
- 2015-06-03 WO PCT/US2015/034018 patent/WO2015187851A1/en not_active Ceased
- 2015-06-03 JP JP2017516256A patent/JP2017516868A/ja not_active Withdrawn
- 2015-06-03 EP EP20204995.3A patent/EP3795156A1/en active Pending
- 2015-06-03 HR HRP20210901TT patent/HRP20210901T1/hr unknown
- 2015-06-03 LT LTEP15803364.7T patent/LT3151832T/lt unknown
- 2015-06-03 US US14/729,910 patent/US20150352085A1/en not_active Abandoned
- 2015-06-03 SM SM20210343T patent/SMT202100343T1/it unknown
- 2015-06-03 PL PL15803364T patent/PL3151832T3/pl unknown
- 2015-06-03 SM SM20210340T patent/SMT202100340T1/it unknown
- 2015-06-03 HU HUE18169211A patent/HUE055400T2/hu unknown
- 2015-06-03 MX MX2020012404A patent/MX391502B/es unknown
- 2015-06-05 AR ARP150101808A patent/AR100772A1/es not_active Application Discontinuation
- 2015-10-19 US US14/886,764 patent/US9339495B2/en active Active
-
2016
- 2016-04-19 US US15/132,641 patent/US9446028B2/en active Active
- 2016-11-04 US US15/343,690 patent/US9744159B2/en active Active
- 2016-11-29 IL IL249287A patent/IL249287B/en active IP Right Grant
- 2016-12-12 US US15/375,735 patent/US9801864B2/en active Active
-
2017
- 2017-06-09 US US15/618,736 patent/US20170273956A1/en not_active Abandoned
- 2017-09-27 US US15/716,726 patent/US20180015076A1/en not_active Abandoned
-
2018
- 2018-06-29 US US16/023,282 patent/US11278529B2/en active Active
-
2019
- 2019-08-27 IL IL268960A patent/IL268960B/en active IP Right Grant
- 2019-11-29 JP JP2019217208A patent/JP2020063264A/ja not_active Withdrawn
-
2020
- 2020-08-11 AU AU2020217342A patent/AU2020217342B2/en active Active
-
2021
- 2021-06-07 HR HRP20210902TT patent/HRP20210902T1/hr unknown
- 2021-06-10 CY CY20211100510T patent/CY1124368T1/el unknown
- 2021-06-10 CY CY20211100509T patent/CY1124366T1/el unknown
- 2021-07-15 JP JP2021116935A patent/JP2021178836A/ja not_active Withdrawn
- 2021-09-30 US US17/490,650 patent/US20220016091A1/en not_active Abandoned
-
2022
- 2022-01-07 AU AU2022200085A patent/AU2022200085A1/en not_active Abandoned
- 2022-08-08 US US17/882,939 patent/US20230051859A1/en not_active Abandoned
-
2023
- 2023-05-30 JP JP2023088456A patent/JP2023123442A/ja active Pending
-
2024
- 2024-04-22 AU AU2024202604A patent/AU2024202604A1/en active Pending
- 2024-10-03 US US18/905,678 patent/US20250025448A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX380868B (es) | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. | |
| MX2024010140A (es) | Nuevos metodos. | |
| CY1123460T1 (el) | Ενωσεις και μεθοδοι για τη θεραπεια μιας επιληπτικης διαταραχης | |
| EA201591290A3 (ru) | Креноланиб для лечения пролиферативных расстройств, связанных с мутацией flt3 | |
| EP4461372A3 (en) | Combinations of checkpoint inhibitors and therapeutics to treat cancer | |
| MX382754B (es) | Terapias combinadas para tratar el cancer. | |
| WO2015112793A3 (en) | Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof | |
| MX2021000148A (es) | Inhibidores eterociclicos de erk1 y erk2 y su uso en el tratamiento del cancer. | |
| MX366317B (es) | Composiciones y metodos para tratar la inflamacion cronica y las enfermedades inflamatorias. | |
| EA201890059A1 (ru) | Ингибиторы hpk1 и способы их применения | |
| EA201590870A1 (ru) | АМИНОЗАМЕЩЕННЫЕ ИМИДАЗО[1,2-a]ПИРИДИНКАРБОКСАМИДЫ И ИХ ПРИМЕНЕНИЕ | |
| EA201690212A1 (ru) | Способы лечения или профилактики офтальмологических патологических состояний | |
| EA201591610A1 (ru) | Ингибиторы кинуренинового пути | |
| MX382466B (es) | Partículas inmunomodificadoras para el tratamiento de la inflamación. | |
| EA201792116A1 (ru) | Ингибитор янус-киназы | |
| BR112017018964A2 (pt) | uso de plinabulin e métodos para tratar tumor cerebral | |
| CY1121554T1 (el) | Παραγωγο πυρανοχρωμενυλ-φαινολης, και φαρμακευτικη συνθεση για αγωγη μεταβολικου συνδρομου ή φλεγμονωδους παθησης | |
| RU2018135973A (ru) | Фармацевтическая комбинация, содержащая метроформин и дигидрокверценин, и ее применение для лечения рака | |
| EA201690997A1 (ru) | Композиция для применения в лечении стойкого кашля | |
| WO2016029136A8 (en) | 3-amidobenzamides and uses thereof for increasing cellular levels of a3g | |
| EA201691656A2 (ru) | Терапевтические способы с применением норибогаина и родственных соединений | |
| MX2022000845A (es) | Compuestos inhibidores. | |
| AR095594A1 (es) | Métodos para tratar infecciones en pacientes con sobrepeso y obesos usando antibióticos | |
| EA201391438A1 (ru) | Производные сулиндака, применение и получение указанных производных | |
| EA201391820A1 (ru) | Гетероциклические сульфонамидные производные |