MX379456B - Inhibidores de fde9 con estructura básica de imidazotriazinona y estructura básica de imidazopirazinona en el tratamiento de enfermedades periféricas. - Google Patents

Inhibidores de fde9 con estructura básica de imidazotriazinona y estructura básica de imidazopirazinona en el tratamiento de enfermedades periféricas.

Info

Publication number
MX379456B
MX379456B MX2018000283A MX2018000283A MX379456B MX 379456 B MX379456 B MX 379456B MX 2018000283 A MX2018000283 A MX 2018000283A MX 2018000283 A MX2018000283 A MX 2018000283A MX 379456 B MX379456 B MX 379456B
Authority
MX
Mexico
Prior art keywords
basic
treatment
imidazopirazinone
imidazotriazinone
pde9 inhibitors
Prior art date
Application number
MX2018000283A
Other languages
English (en)
Other versions
MX2018000283A (es
Inventor
Kate Wen
Niels Svenstrup
Yazhou Wang
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2018000283A publication Critical patent/MX2018000283A/es
Publication of MX379456B publication Critical patent/MX379456B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a inhibidores de FDE9 y su uso para el tratamiento de la hiperplasia benigna de próstata y la enfermedad de células falciformes.
MX2018000283A 2015-07-07 2016-07-06 Inhibidores de fde9 con estructura básica de imidazotriazinona y estructura básica de imidazopirazinona en el tratamiento de enfermedades periféricas. MX379456B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201500393 2015-07-07
DKPA201500407 2015-07-10
DKPA201600209 2016-04-07
PCT/EP2016/065964 WO2017005786A1 (en) 2015-07-07 2016-07-06 Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases

Publications (2)

Publication Number Publication Date
MX2018000283A MX2018000283A (es) 2018-11-22
MX379456B true MX379456B (es) 2025-03-10

Family

ID=56345156

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018000283A MX379456B (es) 2015-07-07 2016-07-06 Inhibidores de fde9 con estructura básica de imidazotriazinona y estructura básica de imidazopirazinona en el tratamiento de enfermedades periféricas.

Country Status (20)

Country Link
US (5) US10513524B2 (es)
EP (3) EP4335497A3 (es)
CN (2) CN107810187B (es)
AU (2) AU2016289856B2 (es)
BR (1) BR112018000254A2 (es)
CA (1) CA2990521C (es)
DK (2) DK3303339T3 (es)
ES (2) ES2869939T3 (es)
FI (1) FI3865484T3 (es)
HR (2) HRP20240082T1 (es)
HU (2) HUE053968T2 (es)
IL (2) IL280619B2 (es)
LT (1) LT3865484T (es)
MX (1) MX379456B (es)
PL (1) PL3865484T3 (es)
PT (1) PT3865484T (es)
SI (2) SI3303339T1 (es)
TN (1) TN2017000507A1 (es)
WO (1) WO2017005786A1 (es)
ZA (1) ZA201708341B (es)

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WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se Substituted cyclopropyl derivatives
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MA53501A (fr) 2018-08-31 2021-07-07 Imara Inc Inhibiteurs de pde9 pour le traitement de la drépanocytose
BR112021019876A2 (pt) * 2019-04-05 2022-01-18 Imara Inc Inibidores de pde9 para tratar anemia falciforme
TW202108585A (zh) * 2019-05-07 2021-03-01 美商伊馬拉公司 用於治療地中海型貧血之pde9抑制劑
JP7648027B2 (ja) 2019-12-19 2025-03-18 クリア、スペイン、エセ、ア、ウ ウパダシチニブの調製のための方法及び中間体
KR20250057919A (ko) 2020-04-29 2025-04-29 릴레이 테라퓨틱스, 인크. PI3Kα 억제제 및 이의 사용 방법
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease
CN112552339A (zh) * 2020-12-10 2021-03-26 安徽昊帆生物有限公司 一种o-二苯基磷酰羟胺的制备方法
EP4370124A4 (en) * 2021-07-13 2025-05-07 Relay Therapeutics, Inc. PI3KA INHIBITORS AND METHODS OF USE THEREOF
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-（1-羟乙基）吡咯烷-1-羧酸叔丁酯的制备方法
CN120676939A (zh) * 2023-01-13 2025-09-19 传达治疗有限公司 Pi3k抑制剂及其制备和使用方法

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