MX377780B - Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes. - Google Patents
Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes.Info
- Publication number
- MX377780B MX377780B MX2016009911A MX2016009911A MX377780B MX 377780 B MX377780 B MX 377780B MX 2016009911 A MX2016009911 A MX 2016009911A MX 2016009911 A MX2016009911 A MX 2016009911A MX 377780 B MX377780 B MX 377780B
- Authority
- MX
- Mexico
- Prior art keywords
- glycosylation
- overexpression
- recombinant proteins
- modulate
- pathway regulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01101—Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.101)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01143—Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.143)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01094—Protein N-acetylglucosaminyltransferase (2.4.1.94)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933137P | 2014-01-29 | 2014-01-29 | |
| PCT/US2014/069744 WO2015116315A1 (en) | 2014-01-29 | 2014-12-11 | Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016009911A MX2016009911A (es) | 2016-10-28 |
| MX377780B true MX377780B (es) | 2025-03-11 |
Family
ID=53757626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016009911A MX377780B (es) | 2014-01-29 | 2014-12-11 | Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes. |
| MX2020012356A MX2020012356A (es) | 2014-01-29 | 2016-07-29 | Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012356A MX2020012356A (es) | 2014-01-29 | 2016-07-29 | Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10227627B2 (enExample) |
| EP (1) | EP3099806A1 (enExample) |
| JP (4) | JP6474420B2 (enExample) |
| KR (3) | KR102301034B1 (enExample) |
| CN (2) | CN106170554B (enExample) |
| AU (3) | AU2014380174C1 (enExample) |
| BR (1) | BR112016017606A2 (enExample) |
| CA (1) | CA2938079C (enExample) |
| CL (1) | CL2016001900A1 (enExample) |
| EA (2) | EA037565B1 (enExample) |
| IL (3) | IL282517B (enExample) |
| MX (2) | MX377780B (enExample) |
| SG (1) | SG10201912081RA (enExample) |
| WO (1) | WO2015116315A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020251537A1 (en) * | 2019-06-10 | 2020-12-17 | CHO Plus Inc. | Cell lines for high level production of protein-based pharmaceuticals |
| KR101936049B1 (ko) | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
| AU2018235928B2 (en) * | 2017-03-14 | 2023-09-21 | Amgen Inc. | Control of total afucosylated glycoforms of antibodies produced in cell culture |
| IL307155B2 (en) | 2018-05-01 | 2025-11-01 | Amgen Inc | Antibodies with modulated glycan profiles |
| CN109576212B (zh) * | 2018-12-14 | 2021-06-22 | 杭州奕安济世生物药业有限公司 | 高密度接种培养中种子细胞的培养方法及其应用 |
| US20240190951A1 (en) | 2021-04-23 | 2024-06-13 | Amgen Inc. | Anti-tslp antibody compositions and uses thereof |
| MX2023012903A (es) * | 2021-05-03 | 2023-11-08 | Boehringer Ingelheim Int | Metodo para producir spesolimab. |
| CN113684322B (zh) * | 2021-09-09 | 2024-01-23 | 上海药明生物技术有限公司 | 一种降低抗体类蛋白高聚甘露糖型水平的方法 |
| CN114525252B (zh) * | 2022-03-10 | 2023-12-01 | 广州源井生物科技有限公司 | 一种提高mda-mb-231单细胞克隆形成率的单克隆增强培养基与培养方法及其应用 |
| TW202426485A (zh) | 2022-10-26 | 2024-07-01 | 美商安進公司 | 抗ｔｓｌｐ抗體組成物及其用途 |
| WO2026130515A1 (en) * | 2024-12-20 | 2026-06-25 | Wuxi Biologics (Shanghai) Co., Ltd. | Nucleic acid construct, vector, and approach to reduce high mannose of recombinant protein |
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| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
| US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
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| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
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| US20070190057A1 (en) * | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| US20100145032A1 (en) * | 2007-01-18 | 2010-06-10 | Suomen Punainen Risti, Veripalelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
| US20100221823A1 (en) * | 2007-06-11 | 2010-09-02 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
| TW201028431A (en) * | 2008-10-31 | 2010-08-01 | Lonza Ag | Novel tools for the production of glycosylated proteins in host cells |
| US9034341B2 (en) * | 2009-04-20 | 2015-05-19 | Transtech Pharma, Llc | Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions |
| US20130196410A1 (en) * | 2010-03-05 | 2013-08-01 | Alnylam Pharmaceuticals, Inc | Compositions and methods for modifying the glycosylation pattern of a polypeptide |
| AU2011237442A1 (en) * | 2010-04-07 | 2012-10-18 | Momenta Pharmaceuticals, Inc. | High mannose glycans |
| TW201209160A (en) | 2010-04-27 | 2012-03-01 | Lonza Ag | Improved glycosylation of proteins in host cells |
| US9133493B2 (en) | 2011-04-21 | 2015-09-15 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
| SG11201403814RA (en) | 2012-01-11 | 2014-10-30 | Sigma Aldrich Co Llc | Production of recombinant proteins with simple glycoforms |
-
2014
- 2014-12-11 CN CN201480074585.XA patent/CN106170554B/zh active Active
- 2014-12-11 EP EP14821424.0A patent/EP3099806A1/en active Pending
- 2014-12-11 SG SG10201912081RA patent/SG10201912081RA/en unknown
- 2014-12-11 CA CA2938079A patent/CA2938079C/en active Active
- 2014-12-11 EA EA201691532A patent/EA037565B1/ru unknown
- 2014-12-11 EA EA202190244A patent/EA202190244A3/ru unknown
- 2014-12-11 KR KR1020167021676A patent/KR102301034B1/ko active Active
- 2014-12-11 BR BR112016017606A patent/BR112016017606A2/pt not_active Application Discontinuation
- 2014-12-11 WO PCT/US2014/069744 patent/WO2015116315A1/en not_active Ceased
- 2014-12-11 IL IL282517A patent/IL282517B/en unknown
- 2014-12-11 AU AU2014380174A patent/AU2014380174C1/en active Active
- 2014-12-11 JP JP2016549077A patent/JP6474420B2/ja active Active
- 2014-12-11 KR KR1020227019897A patent/KR102519540B1/ko active Active
- 2014-12-11 CN CN202110902965.XA patent/CN113774084B/zh active Active
- 2014-12-11 MX MX2016009911A patent/MX377780B/es active IP Right Grant
- 2014-12-11 KR KR1020217028516A patent/KR102410393B1/ko active Active
-
2016
- 2016-07-24 IL IL246914A patent/IL246914B/en active IP Right Grant
- 2016-07-26 CL CL2016001900A patent/CL2016001900A1/es unknown
- 2016-07-29 MX MX2020012356A patent/MX2020012356A/es unknown
-
2018
- 2018-09-13 US US16/130,879 patent/US10227627B2/en active Active
- 2018-11-15 AU AU2018264100A patent/AU2018264100C1/en active Active
-
2019
- 2019-01-28 JP JP2019011871A patent/JP6797950B2/ja active Active
- 2019-01-29 US US16/261,311 patent/US10655156B2/en active Active
- 2019-11-24 IL IL270861A patent/IL270861B/en active IP Right Grant
-
2020
- 2020-05-15 US US16/875,832 patent/US10907186B2/en active Active
- 2020-09-23 AU AU2020239681A patent/AU2020239681C1/en active Active
- 2020-11-17 JP JP2020190707A patent/JP7034236B2/ja active Active
-
2022
- 2022-02-28 JP JP2022029077A patent/JP7788307B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |