MX372998B - Proteinas de captura de superficie celular recombinantes. - Google Patents

Proteinas de captura de superficie celular recombinantes.

Info

Publication number
MX372998B
MX372998B MX2015006112A MX2015006112A MX372998B MX 372998 B MX372998 B MX 372998B MX 2015006112 A MX2015006112 A MX 2015006112A MX 2015006112 A MX2015006112 A MX 2015006112A MX 372998 B MX372998 B MX 372998B
Authority
MX
Mexico
Prior art keywords
domain
cell surface
recombinant cell
proteins
surface capture
Prior art date
Application number
MX2015006112A
Other languages
English (en)
Other versions
MX2015006112A (es
Inventor
Darya Burakov
Dipali Deshpande
Gang Chen
James Fandl
Thomas Aldrich
Vishal Kamat
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2015006112A publication Critical patent/MX2015006112A/es
Publication of MX372998B publication Critical patent/MX372998B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Se proveen proteínas de captura de superficie celular recombinantes y moléculas de detección que son útiles para aislar y detectar células que producen una proteína de interés (P01) heterodimérica secretada, que tiene un dominio CH3 y/o dominio CH3 sustituido de inmunoglobulina. También se proveen proteínas de captura de superficie celular recombinantes y moléculas de detección que aíslan y detectan anticuerpos biespecíficos. La invención también provee proteínas de unión de antígeno recombinantes que son capaces de reconocer y unirse a proteínas de interés que contienen un dominio CH3 y/o un dominio CH3 modificado, tal como un dominio CH3 con o sin sustituciones de aminoácidos en H95 y Y96 (IMGT).
MX2015006112A 2012-11-14 2013-11-14 Proteinas de captura de superficie celular recombinantes. MX372998B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261726040P 2012-11-14 2012-11-14
PCT/US2013/069993 WO2014078475A2 (en) 2012-11-14 2013-11-14 Recombinant cell surface capture proteins

Publications (2)

Publication Number Publication Date
MX2015006112A MX2015006112A (es) 2015-08-06
MX372998B true MX372998B (es) 2020-05-04

Family

ID=49679651

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015006112A MX372998B (es) 2012-11-14 2013-11-14 Proteinas de captura de superficie celular recombinantes.
MX2019015887A MX2019015887A (es) 2012-11-14 2015-05-14 Proteinas de captura de superficie celular recombinantes.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019015887A MX2019015887A (es) 2012-11-14 2015-05-14 Proteinas de captura de superficie celular recombinantes.

Country Status (19)

Country Link
US (3) US9758592B2 (es)
EP (2) EP2920208B1 (es)
JP (2) JP6668074B2 (es)
KR (3) KR20150084028A (es)
CN (2) CN104797598B (es)
AR (2) AR093491A1 (es)
AU (3) AU2013344769B2 (es)
BR (1) BR112015010758A2 (es)
CA (2) CA3204343A1 (es)
DK (2) DK2920208T3 (es)
EA (2) EA037546B1 (es)
ES (2) ES2805526T3 (es)
IL (3) IL285015B2 (es)
MX (2) MX372998B (es)
PL (2) PL2949667T3 (es)
SG (2) SG11201502629TA (es)
TW (4) TWI864338B (es)
WO (1) WO2014078475A2 (es)
ZA (1) ZA201502538B (es)

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JP2024527197A (ja) * 2021-07-30 2024-07-23 チェンドゥ ユノヴェル バイオファーマ カンパニー リミテッド． 組換えｃｈｏ細胞、その構築方法、並びにそれを用いた検出システム及び方法
CN119638849A (zh) * 2021-10-18 2025-03-18 深圳科兴药业有限公司 一种生长激素融合蛋白及其应用
US12195546B2 (en) 2022-12-19 2025-01-14 Sanofi CD28/OX40 bispecific antibodies

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Also Published As

Publication number Publication date
AU2013344769B2 (en) 2018-11-15
AU2013344769A1 (en) 2015-05-21
CN109485728A (zh) 2019-03-19
JP6856593B2 (ja) 2021-04-07
SG11201502629TA (en) 2015-05-28
US20210009714A1 (en) 2021-01-14
MX2019015887A (es) 2020-02-07
US20180118852A1 (en) 2018-05-03
EA202190266A1 (ru) 2021-07-30
EA037546B1 (ru) 2021-04-12
EP2949667A3 (en) 2016-02-24
AU2018253474A1 (en) 2018-11-15
CA3204343A1 (en) 2014-05-22
AR121002A2 (es) 2022-04-06
MX2015006112A (es) 2015-08-06
IL285015B2 (en) 2024-12-01
JP2015536345A (ja) 2015-12-21
CA2889541C (en) 2023-07-04
IL238176A0 (en) 2015-05-31
DK2949667T3 (da) 2020-07-20
IL285015A (en) 2021-08-31
ZA201502538B (en) 2017-09-27
EP2949667A2 (en) 2015-12-02
KR102563030B1 (ko) 2023-08-03
TWI864338B (zh) 2024-12-01
TW201439121A (zh) 2014-10-16
DK2920208T3 (da) 2020-09-14
KR20230119245A (ko) 2023-08-16
US9758592B2 (en) 2017-09-12
AU2021202371A1 (en) 2021-05-13
TWI745610B (zh) 2021-11-11
EP2920208B1 (en) 2020-08-19
HK1211036A1 (en) 2016-05-13
TW202206465A (zh) 2022-02-16
KR20210014766A (ko) 2021-02-09
AU2018253474B2 (en) 2021-01-21
CN104797598A (zh) 2015-07-22
US20140134719A1 (en) 2014-05-15
KR20150084028A (ko) 2015-07-21
KR20220025902A (ko) 2022-03-03
IL275270A (en) 2020-07-30
EA201590928A1 (ru) 2015-09-30
BR112015010758A2 (pt) 2017-08-22
JP2019023199A (ja) 2019-02-14
HK1214612A1 (en) 2016-07-29
IL285015B1 (en) 2024-08-01
TWI675044B (zh) 2019-10-21
CA2889541A1 (en) 2014-05-22
PL2920208T3 (pl) 2021-02-08
ES2817373T3 (es) 2021-04-07
IL238176B (en) 2020-06-30
IL275270B (en) 2021-08-31
PL2949667T3 (pl) 2020-11-16
ES2805526T3 (es) 2021-02-12
CN104797598B (zh) 2018-12-11
AU2021202371B2 (en) 2024-10-03
TW202423993A (zh) 2024-06-16
EP2949667B1 (en) 2020-05-13
JP6668074B2 (ja) 2020-03-18
WO2014078475A2 (en) 2014-05-22
WO2014078475A3 (en) 2014-11-20
AR093491A1 (es) 2015-06-10
TW201920289A (zh) 2019-06-01
SG10201804124XA (en) 2018-07-30
EP2920208A2 (en) 2015-09-23

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