MX372721B - Ánalogos halogenados de agentes antifi-broticos. - Google Patents

Ánalogos halogenados de agentes antifi-broticos.

Info

Publication number
MX372721B
MX372721B MX2016000325A MX2016000325A MX372721B MX 372721 B MX372721 B MX 372721B MX 2016000325 A MX2016000325 A MX 2016000325A MX 2016000325 A MX2016000325 A MX 2016000325A MX 372721 B MX372721 B MX 372721B
Authority
MX
Mexico
Prior art keywords
antifibrotic agents
halogenated analogues
halogenated
agents
analogues
Prior art date
Application number
MX2016000325A
Other languages
English (en)
Spanish (es)
Inventor
James Kelly Darren
John Williams Spencer
Zammit Steven
Original Assignee
Certa Therapeutics Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Certa Therapeutics Pty Ltd filed Critical Certa Therapeutics Pty Ltd
Publication of MX372721B publication Critical patent/MX372721B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MX2016000325A 2007-12-21 2008-12-19 Ánalogos halogenados de agentes antifi-broticos. MX372721B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1613407P 2007-12-21 2007-12-21
PCT/AU2008/001868 WO2009079692A1 (en) 2007-12-21 2008-12-19 Halogenated analogues of anti-fibrotic agents

Publications (1)

Publication Number Publication Date
MX372721B true MX372721B (es) 2020-05-11

Family

ID=40800565

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016000325A MX372721B (es) 2007-12-21 2008-12-19 Ánalogos halogenados de agentes antifi-broticos.
MX2010006787A MX337320B (es) 2007-12-21 2008-12-19 Análogos halogenados de agentes anti-fibroticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2010006787A MX337320B (es) 2007-12-21 2008-12-19 Análogos halogenados de agentes anti-fibroticos.

Country Status (12)

Country Link
US (1) US8624056B2 (enExample)
EP (2) EP2220028B1 (enExample)
JP (2) JP5730578B2 (enExample)
KR (2) KR20160017139A (enExample)
CN (2) CN102164887A (enExample)
AU (1) AU2008341010B2 (enExample)
CA (1) CA2709937C (enExample)
MX (2) MX372721B (enExample)
NZ (1) NZ584613A (enExample)
SG (1) SG10201506526QA (enExample)
WO (1) WO2009079692A1 (enExample)
ZA (1) ZA201003376B (enExample)

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IN2012DN03312A (enExample) 2009-10-22 2015-10-23 Fibrotech Therapeutics Pty Ltd
NZ609144A (en) * 2010-11-24 2014-08-29 Occurx Pty Ltd Methods of treating eye diseases associated with inflammation and vascular proliferation
AU2014233055B2 (en) * 2013-03-15 2018-08-09 Board Of Regents, The University Of Texas System Inhibition of pulmonary fibrosis with nutlin-3a and peptides
ES2806027T3 (es) * 2013-11-26 2021-02-16 Univ Yale Nuevas composiciones penetrantes de células y métodos de uso de las mismas
JP6533997B2 (ja) * 2014-12-26 2019-06-26 株式会社ヤクルト本社 Znf143阻害活性を有する化合物およびその利用
EP3577103A1 (en) 2017-02-03 2019-12-11 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
CN110357789B (zh) * 2018-04-11 2022-09-30 华东理工大学 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途
AU2022238294A1 (en) * 2021-03-17 2023-10-05 Occurx Pty Ltd Compounds for the treatment of disorders and salts and polymorphs thereof
CN116730977A (zh) * 2022-03-04 2023-09-12 华东理工大学 新型芳基杂环类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
CN107162928A (zh) 2017-09-15
JP6063985B2 (ja) 2017-01-18
EP3045170A1 (en) 2016-07-20
AU2008341010A1 (en) 2009-07-02
MX337320B (es) 2016-01-06
CA2709937A1 (en) 2009-07-02
JP5730578B2 (ja) 2015-06-10
EP2220028A1 (en) 2010-08-25
EP2220028A4 (en) 2011-02-16
US8624056B2 (en) 2014-01-07
EP3045170B1 (en) 2018-07-04
JP2015180624A (ja) 2015-10-15
MX2010006787A (es) 2010-10-04
CN102164887A (zh) 2011-08-24
EP2220028B1 (en) 2016-03-09
KR20100099134A (ko) 2010-09-10
US20110021815A1 (en) 2011-01-27
CA2709937C (en) 2016-03-22
NZ584613A (en) 2011-07-29
WO2009079692A1 (en) 2009-07-02
SG10201506526QA (en) 2015-09-29
JP2011506490A (ja) 2011-03-03
AU2008341010B2 (en) 2013-04-18
KR101593708B1 (ko) 2016-02-12
ZA201003376B (en) 2011-02-23
KR20160017139A (ko) 2016-02-15
US20120059188A9 (en) 2012-03-08
CN107162928B (zh) 2022-03-11

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