NZ584613A - Halogenated cinnamoylbenzamide derivatives for anti-fibrotic drugs - Google Patents

Halogenated cinnamoylbenzamide derivatives for anti-fibrotic drugs

Info

Publication number
NZ584613A
NZ584613A NZ584613A NZ58461308A NZ584613A NZ 584613 A NZ584613 A NZ 584613A NZ 584613 A NZ584613 A NZ 584613A NZ 58461308 A NZ58461308 A NZ 58461308A NZ 584613 A NZ584613 A NZ 584613A
Authority
NZ
New Zealand
Prior art keywords
optionally substituted
group
compound according
alkyl
substituted
Prior art date
Application number
NZ584613A
Other languages
English (en)
Inventor
Darren James Kelly
Spencer John Williams
Steven Zammit
Original Assignee
Fibrotech Therapeutics Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrotech Therapeutics Pty Ltd filed Critical Fibrotech Therapeutics Pty Ltd
Publication of NZ584613A publication Critical patent/NZ584613A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ584613A 2007-12-21 2008-12-19 Halogenated cinnamoylbenzamide derivatives for anti-fibrotic drugs NZ584613A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1613407P 2007-12-21 2007-12-21
PCT/AU2008/001868 WO2009079692A1 (en) 2007-12-21 2008-12-19 Halogenated analogues of anti-fibrotic agents

Publications (1)

Publication Number Publication Date
NZ584613A true NZ584613A (en) 2011-07-29

Family

ID=40800565

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ584613A NZ584613A (en) 2007-12-21 2008-12-19 Halogenated cinnamoylbenzamide derivatives for anti-fibrotic drugs

Country Status (12)

Country Link
US (1) US8624056B2 (enExample)
EP (2) EP2220028B1 (enExample)
JP (2) JP5730578B2 (enExample)
KR (2) KR20160017139A (enExample)
CN (2) CN102164887A (enExample)
AU (1) AU2008341010B2 (enExample)
CA (1) CA2709937C (enExample)
MX (2) MX372721B (enExample)
NZ (1) NZ584613A (enExample)
SG (1) SG10201506526QA (enExample)
WO (1) WO2009079692A1 (enExample)
ZA (1) ZA201003376B (enExample)

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US8765812B2 (en) 2006-07-05 2014-07-01 Fibrotech Therapeutics Pty Ltd Therapeutic compounds
JP5730578B2 (ja) 2007-12-21 2015-06-10 フィブロテック セラピューティクス プロプライエタリー リミテッド 抗線維症剤のハロゲン化類似体
IN2012DN03312A (enExample) 2009-10-22 2015-10-23 Fibrotech Therapeutics Pty Ltd
NZ609144A (en) * 2010-11-24 2014-08-29 Occurx Pty Ltd Methods of treating eye diseases associated with inflammation and vascular proliferation
AU2014233055B2 (en) * 2013-03-15 2018-08-09 Board Of Regents, The University Of Texas System Inhibition of pulmonary fibrosis with nutlin-3a and peptides
ES2806027T3 (es) * 2013-11-26 2021-02-16 Univ Yale Nuevas composiciones penetrantes de células y métodos de uso de las mismas
JP6533997B2 (ja) * 2014-12-26 2019-06-26 株式会社ヤクルト本社 Ｚｎｆ１４３阻害活性を有する化合物およびその利用
EP3577103A1 (en) 2017-02-03 2019-12-11 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
CN110357789B (zh) * 2018-04-11 2022-09-30 华东理工大学 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途
AU2022238294A1 (en) * 2021-03-17 2023-10-05 Occurx Pty Ltd Compounds for the treatment of disorders and salts and polymorphs thereof
CN116730977A (zh) * 2022-03-04 2023-09-12 华东理工大学 新型芳基杂环类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
CN107162928A (zh) 2017-09-15
JP6063985B2 (ja) 2017-01-18
EP3045170A1 (en) 2016-07-20
AU2008341010A1 (en) 2009-07-02
MX337320B (es) 2016-01-06
CA2709937A1 (en) 2009-07-02
JP5730578B2 (ja) 2015-06-10
EP2220028A1 (en) 2010-08-25
EP2220028A4 (en) 2011-02-16
US8624056B2 (en) 2014-01-07
EP3045170B1 (en) 2018-07-04
JP2015180624A (ja) 2015-10-15
MX2010006787A (es) 2010-10-04
CN102164887A (zh) 2011-08-24
MX372721B (es) 2020-05-11
EP2220028B1 (en) 2016-03-09
KR20100099134A (ko) 2010-09-10
US20110021815A1 (en) 2011-01-27
CA2709937C (en) 2016-03-22
WO2009079692A1 (en) 2009-07-02
SG10201506526QA (en) 2015-09-29
JP2011506490A (ja) 2011-03-03
AU2008341010B2 (en) 2013-04-18
KR101593708B1 (ko) 2016-02-12
ZA201003376B (en) 2011-02-23
KR20160017139A (ko) 2016-02-15
US20120059188A9 (en) 2012-03-08
CN107162928B (zh) 2022-03-11

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