MX370113B - Moduladores alostericos positivos del receptor muscarinico m2. - Google Patents

Moduladores alostericos positivos del receptor muscarinico m2.

Info

Publication number
MX370113B
MX370113B MX2017016055A MX2017016055A MX370113B MX 370113 B MX370113 B MX 370113B MX 2017016055 A MX2017016055 A MX 2017016055A MX 2017016055 A MX2017016055 A MX 2017016055A MX 370113 B MX370113 B MX 370113B
Authority
MX
Mexico
Prior art keywords
muscarinic
receptor
positive allosteric
allosteric modulators
prevention
Prior art date
Application number
MX2017016055A
Other languages
English (en)
Other versions
MX2017016055A (es
Inventor
Müller Thomas
Rebstock Anne-Sophie
Marquardt Tobias
Nowak-Reppel Katrin
Teller Henrik
Tinel Hanna
Mondritzki Thomas
Vakalopoulos Alexandros
Straub Alexander
Brechmann Markus
Meininghaus Mark
Münter Klaus
Fliegner Daniela
Boultadakis Arapinis Melissa
Beat Wittwer Matthias
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2017016055A publication Critical patent/MX2017016055A/es
Publication of MX370113B publication Critical patent/MX370113B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente solicitud se refiere a moduladores alostéricos positivos del receptor de M2 muscarínico, especialmente a 1-arilnaftiridina-3-carboxamidas 7 sustituidas novedosas, a los procesos de preparación de los mismos, al uso de los mismos, por sí solos o en combinaciones para tratar y/o prevenir enfermedades y al uso de las mismos para producir medicamentos para tratar y/o prevenir enfermedades, en particular para tratar y/o prevenir trastornos cardiovasculares y/o trastornos renales.
MX2017016055A 2015-06-09 2016-06-06 Moduladores alostericos positivos del receptor muscarinico m2. MX370113B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15171127 2015-06-09
EP16156676 2016-02-22
PCT/EP2016/062737 WO2016198342A1 (de) 2015-06-09 2016-06-06 Positiv allosterische modulatoren des muskarinergen m2 rezeptors

Publications (2)

Publication Number Publication Date
MX2017016055A MX2017016055A (es) 2018-02-21
MX370113B true MX370113B (es) 2019-12-02

Family

ID=56101466

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016055A MX370113B (es) 2015-06-09 2016-06-06 Moduladores alostericos positivos del receptor muscarinico m2.

Country Status (27)

Country Link
US (2) US10435403B2 (es)
EP (2) EP3307741B1 (es)
JP (1) JP6908536B2 (es)
KR (1) KR20180016485A (es)
CN (1) CN107949562B (es)
AU (1) AU2016274433B2 (es)
BR (1) BR112017026561A2 (es)
CA (1) CA2988468A1 (es)
CL (1) CL2017003124A1 (es)
CO (1) CO2017012622A2 (es)
CR (1) CR20170566A (es)
CU (1) CU20170158A7 (es)
DO (1) DOP2017000288A (es)
EA (1) EA035465B1 (es)
EC (1) ECSP17081322A (es)
HK (1) HK1254348A1 (es)
IL (2) IL256119A (es)
MX (1) MX370113B (es)
NI (1) NI201700154A (es)
PE (1) PE20180252A1 (es)
PH (1) PH12017502224A1 (es)
SG (1) SG11201710164QA (es)
TN (1) TN2017000498A1 (es)
TW (1) TW201716405A (es)
UY (1) UY36714A (es)
WO (1) WO2016198342A1 (es)
ZA (1) ZA201800125B (es)

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BR112018074450A2 (pt) 2016-06-02 2019-03-19 Cloudbreak Therapeutics, Llc composições e métodos para a utilização de nintedanib para melhorar o sucesso da cirurgia do glaucoma
JP2019524722A (ja) 2016-07-11 2019-09-05 バイエル・ファルマ・アクティエンゲゼルシャフト ７−置換１−ピリジル−ナフチリジン−３−カルボン酸アミドおよびその使用
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
CN110215899B (zh) * 2019-04-01 2022-03-25 重庆科技学院 一种氨基酸功能化的金属有机骨架材料及其制备方法和应用
EP4027997A4 (en) * 2019-09-10 2023-10-11 Cloudbreak Therapeutics, LLC METHOD FOR RELIEVING PTERYGIUM-ASSOCIATED DETERROR IN EYE APPEARANCE
CN111057045A (zh) * 2019-12-18 2020-04-24 安徽红杉生物医药科技有限公司 Hcv ns3/4a蛋白酶抑制剂中间体及其合成方法、应用
CA3170415A1 (en) * 2020-03-03 2021-09-10 Anna M. Ericsson Compounds targeting rna-binding proteins or rna-modifying proteins
CN114105881B (zh) 2020-08-31 2024-01-26 沈阳海诺威医药科技有限公司 血小板聚集抑制剂及其制备方法和用途
CN113072480B (zh) * 2021-04-13 2022-09-30 常州佳德医药科技有限公司 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用

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JP2019524722A (ja) 2016-07-11 2019-09-05 バイエル・ファルマ・アクティエンゲゼルシャフト ７−置換１−ピリジル−ナフチリジン−３−カルボン酸アミドおよびその使用
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.

Also Published As

Publication number Publication date
US10435403B2 (en) 2019-10-08
ECSP17081322A (es) 2018-01-31
US20180297994A1 (en) 2018-10-18
CA2988468A1 (en) 2016-12-15
PH12017502224A1 (en) 2018-06-04
EP3307741A1 (de) 2018-04-18
SG11201710164QA (en) 2018-01-30
EP3692991A1 (de) 2020-08-12
IL272017A (en) 2020-02-27
PE20180252A1 (es) 2018-02-02
UY36714A (es) 2016-12-30
WO2016198342A1 (de) 2016-12-15
EA201890002A1 (ru) 2018-04-30
KR20180016485A (ko) 2018-02-14
BR112017026561A2 (pt) 2018-08-14
ZA201800125B (en) 2019-07-31
EA035465B1 (ru) 2020-06-22
TW201716405A (zh) 2017-05-16
DOP2017000288A (es) 2018-01-31
EP3307741B1 (de) 2020-10-28
IL256119A (en) 2018-02-28
CU20170158A7 (es) 2018-06-05
MX2017016055A (es) 2018-02-21
AU2016274433B2 (en) 2020-07-16
CN107949562B (zh) 2021-07-23
HK1254348A1 (zh) 2019-07-19
AU2016274433A1 (en) 2018-01-04
NI201700154A (es) 2018-10-19
CN107949562A (zh) 2018-04-20
TN2017000498A1 (en) 2019-04-12
US20190367516A1 (en) 2019-12-05
JP2018516970A (ja) 2018-06-28
CO2017012622A2 (es) 2018-03-28
CR20170566A (es) 2018-03-20
CL2017003124A1 (es) 2018-06-01
JP6908536B2 (ja) 2021-07-28

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