MX369518B - Combinacion de inhibidor de p13k e inhibidor de c-met. - Google Patents
Combinacion de inhibidor de p13k e inhibidor de c-met.Info
- Publication number
- MX369518B MX369518B MX2015002005A MX2015002005A MX369518B MX 369518 B MX369518 B MX 369518B MX 2015002005 A MX2015002005 A MX 2015002005A MX 2015002005 A MX2015002005 A MX 2015002005A MX 369518 B MX369518 B MX 369518B
- Authority
- MX
- Mexico
- Prior art keywords
- combination
- inhibitor
- proliferative disease
- met
- pi3k
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683790P | 2012-08-16 | 2012-08-16 | |
| PCT/US2013/054848 WO2014028566A1 (en) | 2012-08-16 | 2013-08-14 | Combination of pi3k inhibitor and c-met inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015002005A MX2015002005A (es) | 2015-10-08 |
| MX369518B true MX369518B (es) | 2019-11-11 |
Family
ID=49004065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015002005A MX369518B (es) | 2012-08-16 | 2013-08-14 | Combinacion de inhibidor de p13k e inhibidor de c-met. |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20150216870A1 (en:Method) |
| EP (1) | EP2885003B1 (en:Method) |
| JP (3) | JP2015529194A (en:Method) |
| KR (2) | KR20210049187A (en:Method) |
| CN (1) | CN105050623B (en:Method) |
| AU (4) | AU2013302702A1 (en:Method) |
| BR (1) | BR112015002528A2 (en:Method) |
| CA (1) | CA2879704A1 (en:Method) |
| ES (1) | ES2901712T3 (en:Method) |
| HK (1) | HK1211476A1 (en:Method) |
| IN (1) | IN2015DN00528A (en:Method) |
| MX (1) | MX369518B (en:Method) |
| RU (1) | RU2705095C2 (en:Method) |
| WO (1) | WO2014028566A1 (en:Method) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140069235A (ko) | 2011-09-27 | 2014-06-09 | 노파르티스 아게 | 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| US9434719B2 (en) | 2013-03-14 | 2016-09-06 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| JP2016522247A (ja) * | 2013-06-18 | 2016-07-28 | ノバルティス アーゲー | 組合せ医薬 |
| AU2014296887A1 (en) | 2013-08-02 | 2016-01-28 | Aduro Biotech Holdings, Europe B.V. | Combining CD27 agonists and immune checkpoint inhibition for immune stimulation |
| SG11201700147SA (en) | 2014-07-25 | 2017-02-27 | Novartis Ag | Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide |
| EP3229803B1 (en) | 2014-12-12 | 2020-01-29 | Massachusetts General Hospital | Treatment of breast cancer brain metastases |
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| MX2022007625A (es) * | 2019-12-20 | 2022-08-16 | Recurium Ip Holdings Llc | Combinaciones. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0211649D0 (en) * | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| PL3034075T3 (pl) * | 2006-11-22 | 2019-03-29 | Incyte Holdings Corporation | Imidazotriazyny i imidazopirymidyny jako inhibitory kinaz |
| KR101472607B1 (ko) * | 2007-02-20 | 2014-12-15 | 노파르티스 아게 | 지질 키나제 및 ｍＴＯＲ의 이중 억제제로서의 이미다조퀴놀린 |
| PT2259800E (pt) * | 2008-03-05 | 2014-08-06 | Novartis Ag | Utililização de 5-(2,6-di-morfolin-4-il-pirimidin-4-il)-4- trifluorometil-piridin-2-ilamina para o tratamento de carcinoma pulmonar de não pequenas células com resistência adquirida aos moduladores do receptor de factor de crescimento epidérmico (egfr) |
| MX2010012718A (es) * | 2008-05-21 | 2011-04-04 | Incyte Corp | Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b ][1,2,4] triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas. |
| CA2729914A1 (en) * | 2008-07-11 | 2010-01-14 | Novartis Ag | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| WO2010121175A1 (en) * | 2009-04-17 | 2010-10-21 | Rush University Medical Center | Combination targeted therapy for lung cancer |
| AR083267A1 (es) * | 2010-10-04 | 2013-02-13 | Novartis Ag | Combinaciones farmaceuticas |
| MX360157B (es) | 2010-11-08 | 2018-10-24 | Novartis Ag | Uso de derivados de 2-carboxamida-cicloamino-urea en el tratamiento de enfermedades dependientes de egfr o de enfermedades que han adquirido resistencia a los agentes que tienen como objetivo los miembros de la familia egfr. |
-
2013
- 2013-08-14 RU RU2015108755A patent/RU2705095C2/ru active
- 2013-08-14 CN CN201380043882.3A patent/CN105050623B/zh not_active Expired - Fee Related
- 2013-08-14 IN IN528DEN2015 patent/IN2015DN00528A/en unknown
- 2013-08-14 US US14/420,792 patent/US20150216870A1/en not_active Abandoned
- 2013-08-14 CA CA2879704A patent/CA2879704A1/en not_active Abandoned
- 2013-08-14 WO PCT/US2013/054848 patent/WO2014028566A1/en active Application Filing
- 2013-08-14 ES ES13751058T patent/ES2901712T3/es active Active
- 2013-08-14 KR KR1020217012172A patent/KR20210049187A/ko not_active Ceased
- 2013-08-14 BR BR112015002528-5A patent/BR112015002528A2/pt not_active Application Discontinuation
- 2013-08-14 HK HK15112283.4A patent/HK1211476A1/xx unknown
- 2013-08-14 EP EP13751058.2A patent/EP2885003B1/en active Active
- 2013-08-14 KR KR1020157003716A patent/KR102245985B1/ko not_active Expired - Fee Related
- 2013-08-14 MX MX2015002005A patent/MX369518B/es active IP Right Grant
- 2013-08-14 AU AU2013302702A patent/AU2013302702A1/en not_active Abandoned
- 2013-08-14 JP JP2015527558A patent/JP2015529194A/ja not_active Withdrawn
-
2016
- 2016-10-06 AU AU2016238903A patent/AU2016238903A1/en not_active Abandoned
-
2017
- 2017-10-18 JP JP2017201774A patent/JP6644042B2/ja active Active
-
2018
- 2018-03-09 AU AU2018201725A patent/AU2018201725A1/en not_active Abandoned
- 2018-10-11 US US16/157,333 patent/US20190083500A1/en not_active Abandoned
-
2019
- 2019-07-30 US US16/526,027 patent/US20190350935A1/en not_active Abandoned
- 2019-09-05 AU AU2019226212A patent/AU2019226212B2/en not_active Ceased
-
2020
- 2020-01-07 JP JP2020000928A patent/JP6970217B2/ja not_active Expired - Fee Related
- 2020-03-17 US US16/820,886 patent/US20200253980A1/en not_active Abandoned
-
2021
- 2021-12-15 US US17/644,491 patent/US20220280523A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20190350935A1 (en) | 2019-11-21 |
| WO2014028566A1 (en) | 2014-02-20 |
| JP2018035188A (ja) | 2018-03-08 |
| RU2705095C2 (ru) | 2019-11-05 |
| CN105050623B (zh) | 2018-06-12 |
| KR20210049187A (ko) | 2021-05-04 |
| EP2885003A1 (en) | 2015-06-24 |
| IN2015DN00528A (en:Method) | 2015-06-26 |
| US20220280523A1 (en) | 2022-09-08 |
| EP2885003B1 (en) | 2021-09-29 |
| US20190083500A1 (en) | 2019-03-21 |
| AU2013302702A1 (en) | 2015-02-19 |
| JP2020079243A (ja) | 2020-05-28 |
| KR20150043328A (ko) | 2015-04-22 |
| HK1211476A1 (en) | 2016-05-27 |
| US20200253980A1 (en) | 2020-08-13 |
| CA2879704A1 (en) | 2014-02-20 |
| US20150216870A1 (en) | 2015-08-06 |
| MX2015002005A (es) | 2015-10-08 |
| JP6970217B2 (ja) | 2021-11-24 |
| BR112015002528A2 (pt) | 2018-05-22 |
| CN105050623A (zh) | 2015-11-11 |
| AU2016238903A1 (en) | 2016-10-27 |
| JP2015529194A (ja) | 2015-10-05 |
| AU2019226212B2 (en) | 2020-05-14 |
| ES2901712T3 (es) | 2022-03-23 |
| AU2019226212A1 (en) | 2019-09-26 |
| JP6644042B2 (ja) | 2020-02-12 |
| RU2015108755A (ru) | 2016-10-10 |
| AU2018201725A1 (en) | 2018-04-05 |
| KR102245985B1 (ko) | 2021-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015002005A (es) | Combinacion de inhibidor de p13k e inhibidor de c-met. | |
| MX2020012165A (es) | Derivados de bencimidazol como inhibidores de tirosina cinasa erbb para el tratamiento del cancer. | |
| ECSP15008695A (es) | Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr y opcionalmente un inhibidor de pi3k-alfa | |
| WO2014194254A8 (en) | Treatment of cancers using pi3 kinase isoform modulators | |
| MX2013011908A (es) | Composiciones y usos terapeuticos de inhibidores de cinasa epsilon relacionados con cinasa i-kappa b (ikk) y cinasa 1 de union tank. | |
| GB201205669D0 (en) | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof | |
| PH12016502353A1 (en) | Pharmaceutical composition | |
| CY1119391T1 (el) | Παραγωγα οξαζολιδιν-2- ονη- πυριμιδινης | |
| MX371119B (es) | Productos de combinacion con los inhibidores de cinasa de tirosina y su uso. | |
| TW201613577A (en) | Pharmaceutical combinations | |
| MA39765A (fr) | Formulation pharmaceutique d'un inhibiteur de la kinase pan-raf, ses procédés de préparation, et procédés d'utilisation | |
| PH12014502547A1 (en) | Dosage regimen for a pi-3 kinase inhibitor | |
| MX2019001467A (es) | Combinación de antagonistas del receptor de glucagon e inhibidores de la trayectoria p13k para el tratamiento del cáncer. | |
| TN2015000386A1 (en) | Formulations of organic compounds | |
| MX2016003522A (es) | Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa. | |
| NZ602807A (en) | 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one and an mtor inhibitor | |
| MX2016006894A (es) | Terapia de combinacion que comprende un inhibidor de jak, cdk y pim. | |
| EA201792445A1 (ru) | Новые амидогетероарилароилгидразидэтины | |
| BR112015012497A2 (pt) | combinações farmacêuticas | |
| BR112015005392A2 (pt) | formulação de comprimido de um inibidor de fosfatidilinositol 3-cinase | |
| PH12016502107A1 (en) | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders | |
| PH12016500444A1 (en) | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors | |
| WO2014155268A3 (en) | Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity | |
| MX2014014813A (es) | Uso de agonistas o antagonistas inversos para el receptor de grelina para tratar trastornos del sueño. | |
| EA201500366A1 (ru) | Применение 1-адамантилетилокси-3-морфолино-2-пропанола или его фармацевтически приемлемых солей в фармацевтических композициях в качестве нейроретинопротектора |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |