MX368034B - Panel de marcadores genéticos para el diagnóstico de cáncer colorrectal. - Google Patents

Panel de marcadores genéticos para el diagnóstico de cáncer colorrectal.

Info

Publication number
MX368034B
MX368034B MX2014013684A MX2014013684A MX368034B MX 368034 B MX368034 B MX 368034B MX 2014013684 A MX2014013684 A MX 2014013684A MX 2014013684 A MX2014013684 A MX 2014013684A MX 368034 B MX368034 B MX 368034B
Authority
MX
Mexico
Prior art keywords
onset
colorectal cancer
screening
gene marker
marker panel
Prior art date
Application number
MX2014013684A
Other languages
English (en)
Other versions
MX2014013684A (es
Inventor
Molloy Peter
Lapointe Lawrence
Pedersen Susanne
Original Assignee
Clinical Genomics Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Genomics Pty Ltd filed Critical Clinical Genomics Pty Ltd
Publication of MX2014013684A publication Critical patent/MX2014013684A/es
Publication of MX368034B publication Critical patent/MX368034B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Abstract

La presente invención se refiere un método de tamizaje para el inicio o predisposición al inicio de o el monitoreo de neoplasia del intestino grueso en un individuo, dicho método está caracterizado porque comprende evaluar el estado de metilación de: (i) la región de ADN, incluyendo 2kb hacia el extremo 5´del sitio de inicio de la transcripción de las coordinadas de HG-19: (1) chr12:24962958.24102393, en combinación con una o más de las siguientes regiones de ADN, incluyendo 2kb hacia el extremo 5´del sitio de inicio de la transcripción de las coordenadas de HG19: (2) chr7:50344378...50472798, (3) chr6:391739..411443, (4) chr12:52400748...52409671, y (5) chr6:163834097...163834982, o (ii) la región de gen, incluyendo 2kb hacia el extremo 5´de: (1) BCAT1, en combinación con una o más de las siguientes regiones de ADN, incluyendo 2kb hacia el extremo 5´ de: (2) IKZF1, (3) IRF4, (4) GRASP, y (5) CAHM, en una muestra biológica de dicho individuo en donde un nivel más alto de metilación de por lo menos una de las regiones de ADN del grupo(i) y/o (ii) con relación a los niveles de control es indicativo de neoplasia del intestino grueso o una predisposición al inicio de un estado neoplástico del intestino grueso.
MX2014013684A 2012-05-11 2013-05-10 Panel de marcadores genéticos para el diagnóstico de cáncer colorrectal. MX368034B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261646174P 2012-05-11 2012-05-11
PCT/AU2013/000481 WO2013166558A1 (en) 2012-05-11 2013-05-10 Diagnostic gene marker panel for colorectal cancer

Publications (2)

Publication Number Publication Date
MX2014013684A MX2014013684A (es) 2015-06-10
MX368034B true MX368034B (es) 2019-09-17

Family

ID=49549996

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014013684A MX368034B (es) 2012-05-11 2013-05-10 Panel de marcadores genéticos para el diagnóstico de cáncer colorrectal.
MX2019010935A MX2019010935A (es) 2012-05-11 2014-11-10 Panel de marcadores geneticos para el diagnostico de cancer colorrectal.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019010935A MX2019010935A (es) 2012-05-11 2014-11-10 Panel de marcadores geneticos para el diagnostico de cancer colorrectal.

Country Status (15)

Country Link
US (2) US11254985B2 (es)
EP (3) EP3594366B1 (es)
JP (3) JP6742726B2 (es)
CN (1) CN104411835B (es)
AU (3) AU2013258880B2 (es)
BR (1) BR112014028122B1 (es)
CA (3) CA3083314C (es)
DK (2) DK3594366T3 (es)
ES (1) ES2749514T3 (es)
HK (1) HK1208058A1 (es)
IL (1) IL235411A0 (es)
MX (2) MX368034B (es)
NZ (1) NZ701527A (es)
WO (1) WO2013166558A1 (es)
ZA (1) ZA201408120B (es)

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JP6085603B2 (ja) * 2011-08-25 2017-02-22 クリニカル ゲノミクス プロプライエタリー リミテッド 結腸直腸がん及び乳がん診断法におけるｄｎａメチル化
US11254985B2 (en) * 2012-05-11 2022-02-22 Clinical Genomics Pty. Ltd. Diagnostic gene marker panel for colorectal cancer
CA2951141C (en) 2014-06-04 2021-11-30 Quest Diagnostics Investments Incorporated Methylated markers for colorectal cancer
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CN109371138B (zh) * 2018-12-29 2022-10-25 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep4
AU2019200359A1 (en) * 2019-01-18 2020-09-10 Clinical Genomics Pty Ltd Screening method
EP3911756A4 (en) * 2020-03-20 2022-08-10 Singlera Health Technologies (Shanghai) Ltd. SCREENING PROCEDURES AND KITS FOR COLORECTAL NEOPLASMA
CN115927607A (zh) * 2021-08-17 2023-04-07 武汉艾米森生命科技有限公司 生物标志物在胃癌诊断中的应用

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US11254985B2 (en) * 2012-05-11 2022-02-22 Clinical Genomics Pty. Ltd. Diagnostic gene marker panel for colorectal cancer
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Also Published As

Publication number Publication date
CA3083314C (en) 2023-01-31
CA3152533C (en) 2023-10-17
CN104411835A (zh) 2015-03-11
MX2019010935A (es) 2019-10-24
JP2020089378A (ja) 2020-06-11
EP3594366B1 (en) 2021-06-23
EP4001436B1 (en) 2024-03-13
EP2847355A1 (en) 2015-03-18
AU2021265861A1 (en) 2021-12-02
AU2019201294A1 (en) 2019-03-14
WO2013166558A1 (en) 2013-11-14
AU2013258880A1 (en) 2014-11-20
EP2847355A4 (en) 2016-05-25
ZA201408120B (en) 2019-11-27
CN104411835B (zh) 2019-12-20
JP2018198600A (ja) 2018-12-20
US11254985B2 (en) 2022-02-22
CA2872867A1 (en) 2013-11-14
JP6837458B2 (ja) 2021-03-03
EP3594366A1 (en) 2020-01-15
DK2847355T3 (da) 2019-10-14
CA2872867C (en) 2020-09-15
JP6742726B2 (ja) 2020-08-19
BR112014028122A2 (es) 2017-08-15
WO2013166558A8 (en) 2014-12-11
DK3594366T3 (da) 2021-09-13
HK1208058A1 (en) 2016-02-19
CA3083314A1 (en) 2013-11-14
EP4001436A1 (en) 2022-05-25
BR112014028122B1 (pt) 2022-08-23
US20150141275A1 (en) 2015-05-21
AU2013258880B2 (en) 2019-02-14
NZ701527A (en) 2016-07-29
ES2749514T3 (es) 2020-03-20
IL235411A0 (en) 2014-12-31
MX2014013684A (es) 2015-06-10
US20220213559A1 (en) 2022-07-07
EP2847355B1 (en) 2019-07-10
JP6975807B2 (ja) 2021-12-01
AU2019201294B2 (en) 2021-08-19
JP2015515862A (ja) 2015-06-04
CA3152533A1 (en) 2013-11-14

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