MX368017B - Compuestos de indazol como agonistas del receptor de 5-ht4. - Google Patents

Compuestos de indazol como agonistas del receptor de 5-ht4.

Info

Publication number
MX368017B
MX368017B MX2016007857A MX2016007857A MX368017B MX 368017 B MX368017 B MX 368017B MX 2016007857 A MX2016007857 A MX 2016007857A MX 2016007857 A MX2016007857 A MX 2016007857A MX 368017 B MX368017 B MX 368017B
Authority
MX
Mexico
Prior art keywords
compounds
receptor agonists
indazole compounds
formula
relates
Prior art date
Application number
MX2016007857A
Other languages
English (en)
Other versions
MX2016007857A (es
Inventor
Venkateswarlu Jasti
Ramakrishna Nigori
Abdul Rasheed Mohammed
Anil Karbhari Shinde
Reddy Gagginapally Shankar
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of MX2016007857A publication Critical patent/MX2016007857A/es
Publication of MX368017B publication Critical patent/MX368017B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con compuestos de indazol novedosos de la fórmula (I), incluyendo sus estereoisómeros y sus sales farmacéuticamente aceptables. La presente invención también se relaciona con métodos de elaboración de tales compuestos y de composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos de la presente invención son útiles en el tratamiento de varios trastornos que se relacionan con agonistas de receptores de 5-hidroxitriptamina 4 (5-HT4). (Ver fórmula).
MX2016007857A 2013-12-16 2014-02-24 Compuestos de indazol como agonistas del receptor de 5-ht4. MX368017B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5852CH2013 2013-12-16
PCT/IN2014/000116 WO2015092804A1 (en) 2013-12-16 2014-02-24 Indazole compounds as 5-ht4 receptor agonists

Publications (2)

Publication Number Publication Date
MX2016007857A MX2016007857A (es) 2016-09-07
MX368017B true MX368017B (es) 2019-09-13

Family

ID=50736125

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007857A MX368017B (es) 2013-12-16 2014-02-24 Compuestos de indazol como agonistas del receptor de 5-ht4.

Country Status (17)

Country Link
US (1) US9951045B2 (es)
EP (1) EP3099675B1 (es)
JP (1) JP6161823B2 (es)
KR (1) KR101824154B1 (es)
CN (1) CN105873920B (es)
AP (1) AP2016009253A0 (es)
AU (1) AU2014369085B2 (es)
BR (1) BR112016013974B1 (es)
CA (1) CA2932428C (es)
DK (1) DK3099675T3 (es)
EA (1) EA029951B1 (es)
ES (1) ES2668873T3 (es)
IL (1) IL245948B (es)
MX (1) MX368017B (es)
NZ (1) NZ720879A (es)
SG (1) SG11201604849YA (es)
WO (1) WO2015092804A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS60804B1 (sr) 2014-08-16 2020-10-30 Suven Life Sciences Ltd Proces proizvodnje 1-izopropil-3-{5-[1-(3-metoksipropil)piperidin-4-il]-[1,3,4]oksadiazol-2-il}-1h-indazol oksalata u velikom obimu
PT3265459T (pt) * 2015-02-13 2019-07-17 Suven Life Sciences Ltd Compostos amidos como agonistas do recetor 5-ht4
JP6900028B2 (ja) * 2017-03-29 2021-07-07 国立大学法人帯広畜産大学 パーキンソン病に併発した認知障害の治療剤
EP3628660A1 (en) * 2018-09-28 2020-04-01 Université de Caen Normandie Donecopride and flucopride as neuroprotective agents in the treatment of neurodegenerative diseases
EP4317141A1 (en) 2022-08-04 2024-02-07 Curia Spain S.A.U. Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5150393A (en) 1992-10-13 1994-05-09 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
NZ257545A (en) 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
ES2248616T3 (es) 2001-10-22 2006-03-16 Pfizer Inc. Compuestos imidazopiridina como moduladores del receptor 5-ht4.
BRPI0409592A (pt) 2003-04-21 2006-05-02 Pfizer compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3
EP1689742B1 (en) 2003-11-24 2010-03-17 Pfizer, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
CA2551171C (en) * 2003-12-23 2012-07-10 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
RU2404179C2 (ru) * 2004-12-22 2010-11-20 Тереванс, Инк. Индазол-карбоксамидные соединения
US8816090B2 (en) 2005-02-25 2014-08-26 Pfizer Inc. Benzisoxazole derivatives
US7906532B2 (en) 2005-07-22 2011-03-15 Pfizer Inc. Indazole derivatives
ES2640752T3 (es) 2010-02-12 2017-11-06 Askat Inc. Agonistas del receptor 5-HT4 para el tratamiento de la demencia
EP2536713A1 (en) 2010-02-16 2012-12-26 Pfizer Inc. (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
KR101551481B1 (ko) * 2011-09-19 2015-09-08 수벤 라이프 사이언시스 리미티드 ５－ηｔ４ 수용체 리간드인 헤테로아릴 화합물

Also Published As

Publication number Publication date
MX2016007857A (es) 2016-09-07
JP2016540796A (ja) 2016-12-28
BR112016013974A8 (pt) 2018-01-30
US9951045B2 (en) 2018-04-24
CA2932428C (en) 2017-10-24
KR101824154B1 (ko) 2018-03-14
DK3099675T3 (en) 2018-05-22
KR20160075832A (ko) 2016-06-29
EP3099675A1 (en) 2016-12-07
JP6161823B2 (ja) 2017-07-12
IL245948B (en) 2019-08-29
WO2015092804A1 (en) 2015-06-25
BR112016013974B1 (pt) 2022-11-22
AU2014369085B2 (en) 2017-02-23
ES2668873T3 (es) 2018-05-22
CN105873920B (zh) 2018-06-08
EP3099675B1 (en) 2018-02-14
NZ720879A (en) 2017-05-26
SG11201604849YA (en) 2016-07-28
IL245948A0 (en) 2016-08-02
EA201691252A1 (ru) 2016-12-30
AP2016009253A0 (en) 2016-06-30
EA029951B1 (ru) 2018-06-29
US20160311797A1 (en) 2016-10-27
CN105873920A (zh) 2016-08-17
BR112016013974A2 (pt) 2017-08-08
CA2932428A1 (en) 2015-06-25
AU2014369085A1 (en) 2016-06-30

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