SG11201604849YA - INDAZOLE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS - Google Patents
INDAZOLE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTSInfo
- Publication number
- SG11201604849YA SG11201604849YA SG11201604849YA SG11201604849YA SG11201604849YA SG 11201604849Y A SG11201604849Y A SG 11201604849YA SG 11201604849Y A SG11201604849Y A SG 11201604849YA SG 11201604849Y A SG11201604849Y A SG 11201604849YA SG 11201604849Y A SG11201604849Y A SG 11201604849YA
- Authority
- SG
- Singapore
- Prior art keywords
- receptor agonists
- indazole compounds
- indazole
- compounds
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN5852CH2013 | 2013-12-16 | ||
PCT/IN2014/000116 WO2015092804A1 (en) | 2013-12-16 | 2014-02-24 | Indazole compounds as 5-ht4 receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201604849YA true SG11201604849YA (en) | 2016-07-28 |
Family
ID=50736125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201604849YA SG11201604849YA (en) | 2013-12-16 | 2014-02-24 | INDAZOLE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS |
Country Status (17)
Country | Link |
---|---|
US (1) | US9951045B2 (en) |
EP (1) | EP3099675B1 (en) |
JP (1) | JP6161823B2 (en) |
KR (1) | KR101824154B1 (en) |
CN (1) | CN105873920B (en) |
AP (1) | AP2016009253A0 (en) |
AU (1) | AU2014369085B2 (en) |
BR (1) | BR112016013974B1 (en) |
CA (1) | CA2932428C (en) |
DK (1) | DK3099675T3 (en) |
EA (1) | EA029951B1 (en) |
ES (1) | ES2668873T3 (en) |
IL (1) | IL245948B (en) |
MX (1) | MX368017B (en) |
NZ (1) | NZ720879A (en) |
SG (1) | SG11201604849YA (en) |
WO (1) | WO2015092804A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2957498C (en) | 2014-08-16 | 2019-02-12 | Suven Life Sciences Limited | Process for large scale production of 1-isopropyl-3-{5-[1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1h-indazole oxalate |
AU2016217461B2 (en) * | 2015-02-13 | 2018-07-05 | Suven Life Sciences Limited | Amide compounds as 5-HT4 receptor agonists |
JP6900028B2 (en) * | 2017-03-29 | 2021-07-07 | 国立大学法人帯広畜産大学 | A therapeutic agent for cognitive impairment associated with Parkinson's disease |
EP3628660A1 (en) * | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Donecopride and flucopride as neuroprotective agents in the treatment of neurodegenerative diseases |
EP4317141A1 (en) | 2022-08-04 | 2024-02-07 | Curia Spain S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2146930A1 (en) | 1992-10-13 | 1994-04-28 | Francis David King | Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists |
KR950704328A (en) | 1992-11-05 | 1995-11-17 | 데이비드 로버츠 | Piperidine Derivatives as 5-HT 'Receptor Antagonists |
BR0213026A (en) | 2001-10-22 | 2004-10-05 | Pfizer | Imidazopyridine Compounds as 5-ht4 Receptor Regulators |
CA2523077A1 (en) | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
JP4704353B2 (en) | 2003-11-24 | 2011-06-15 | ファイザー株式会社 | Quinoline carboxylic acid compound having 5-HT4 receptor agonist activity |
CA2551171C (en) * | 2003-12-23 | 2012-07-10 | Bio-Medisinsk Innovasjon As | Modulators of peripheral 5-ht receptors |
US7419989B2 (en) * | 2004-12-22 | 2008-09-02 | Theravance, Inc. | Indazole-carboxamide compounds |
ES2523459T3 (en) | 2005-02-25 | 2014-11-26 | Raqualia Pharma Inc | Benzisoxazole derivatives |
EP1910340B1 (en) | 2005-07-22 | 2009-11-18 | Pfizer, Inc. | Indazolecarboxamide derivatives as 5ht4 receptor agonists |
EP2533780B1 (en) * | 2010-02-12 | 2017-08-23 | AskAt Inc. | 5-ht4 receptor agonists for the treatment of dementia |
IN2012DN06631A (en) | 2010-02-16 | 2015-10-23 | Pfizer | |
BR112014001083B8 (en) * | 2011-09-19 | 2022-06-14 | Suven Life Sciences Ltd | Compound, process for preparing a compound, pharmaceutical composition, use of the pharmaceutical composition and use of the compound |
-
2014
- 2014-02-24 EA EA201691252A patent/EA029951B1/en unknown
- 2014-02-24 SG SG11201604849YA patent/SG11201604849YA/en unknown
- 2014-02-24 MX MX2016007857A patent/MX368017B/en active IP Right Grant
- 2014-02-24 AP AP2016009253A patent/AP2016009253A0/en unknown
- 2014-02-24 JP JP2016539987A patent/JP6161823B2/en active Active
- 2014-02-24 WO PCT/IN2014/000116 patent/WO2015092804A1/en active Application Filing
- 2014-02-24 ES ES14725246.4T patent/ES2668873T3/en active Active
- 2014-02-24 KR KR1020167015974A patent/KR101824154B1/en active IP Right Grant
- 2014-02-24 US US15/104,521 patent/US9951045B2/en active Active
- 2014-02-24 CA CA2932428A patent/CA2932428C/en active Active
- 2014-02-24 AU AU2014369085A patent/AU2014369085B2/en not_active Ceased
- 2014-02-24 CN CN201480068132.6A patent/CN105873920B/en active Active
- 2014-02-24 DK DK14725246.4T patent/DK3099675T3/en active
- 2014-02-24 EP EP14725246.4A patent/EP3099675B1/en active Active
- 2014-02-24 BR BR112016013974-7A patent/BR112016013974B1/en active IP Right Grant
- 2014-02-24 NZ NZ720879A patent/NZ720879A/en not_active IP Right Cessation
-
2016
- 2016-05-31 IL IL245948A patent/IL245948B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EA201691252A1 (en) | 2016-12-30 |
MX2016007857A (en) | 2016-09-07 |
BR112016013974A2 (en) | 2017-08-08 |
DK3099675T3 (en) | 2018-05-22 |
IL245948B (en) | 2019-08-29 |
JP2016540796A (en) | 2016-12-28 |
CN105873920A (en) | 2016-08-17 |
CN105873920B (en) | 2018-06-08 |
AU2014369085B2 (en) | 2017-02-23 |
KR20160075832A (en) | 2016-06-29 |
AP2016009253A0 (en) | 2016-06-30 |
ES2668873T3 (en) | 2018-05-22 |
CA2932428A1 (en) | 2015-06-25 |
WO2015092804A1 (en) | 2015-06-25 |
KR101824154B1 (en) | 2018-03-14 |
EP3099675B1 (en) | 2018-02-14 |
CA2932428C (en) | 2017-10-24 |
MX368017B (en) | 2019-09-13 |
AU2014369085A1 (en) | 2016-06-30 |
EA029951B1 (en) | 2018-06-29 |
BR112016013974A8 (en) | 2018-01-30 |
US20160311797A1 (en) | 2016-10-27 |
JP6161823B2 (en) | 2017-07-12 |
EP3099675A1 (en) | 2016-12-07 |
BR112016013974B1 (en) | 2022-11-22 |
NZ720879A (en) | 2017-05-26 |
US9951045B2 (en) | 2018-04-24 |
IL245948A0 (en) | 2016-08-02 |
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