BR112016013974A2 - Composto, composição farmacêutica, uso da composição farmacêutica e uso do composto - Google Patents
Composto, composição farmacêutica, uso da composição farmacêutica e uso do compostoInfo
- Publication number
- BR112016013974A2 BR112016013974A2 BR112016013974A BR112016013974A BR112016013974A2 BR 112016013974 A2 BR112016013974 A2 BR 112016013974A2 BR 112016013974 A BR112016013974 A BR 112016013974A BR 112016013974 A BR112016013974 A BR 112016013974A BR 112016013974 A2 BR112016013974 A2 BR 112016013974A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- compounds
- present
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, USO DA COMPOSIÇÃO FARMACÊUTICA E USO DO COMPOSTO. A presente invenção se refere a novos compostos indazola tendo a fórmula (I), que incluem os seus estereoisômeros e os seus sais farmaceuticamente aceitáveis. A presente invenção também se refere a métodos de produzir os referidos compostos e composições farmacêuticas que compreendem os referidos compostos. Os compostos da presente invenção são úteis no tratamento de várias desordens que são relacionadas aos agonistas receptores de 5-hidroxitriptamina 4 (5-HT4).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN5852/CHE/2013 | 2013-12-16 | ||
IN5852CH2013 | 2013-12-16 | ||
PCT/IN2014/000116 WO2015092804A1 (en) | 2013-12-16 | 2014-02-24 | Indazole compounds as 5-ht4 receptor agonists |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112016013974A2 true BR112016013974A2 (pt) | 2017-08-08 |
BR112016013974A8 BR112016013974A8 (pt) | 2018-01-30 |
BR112016013974B1 BR112016013974B1 (pt) | 2022-11-22 |
Family
ID=50736125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016013974-7A BR112016013974B1 (pt) | 2013-12-16 | 2014-02-24 | Composto, composição farmacêutica, uso da composição farmacêutica e uso do composto |
Country Status (17)
Country | Link |
---|---|
US (1) | US9951045B2 (pt) |
EP (1) | EP3099675B1 (pt) |
JP (1) | JP6161823B2 (pt) |
KR (1) | KR101824154B1 (pt) |
CN (1) | CN105873920B (pt) |
AP (1) | AP2016009253A0 (pt) |
AU (1) | AU2014369085B2 (pt) |
BR (1) | BR112016013974B1 (pt) |
CA (1) | CA2932428C (pt) |
DK (1) | DK3099675T3 (pt) |
EA (1) | EA029951B1 (pt) |
ES (1) | ES2668873T3 (pt) |
IL (1) | IL245948B (pt) |
MX (1) | MX368017B (pt) |
NZ (1) | NZ720879A (pt) |
SG (1) | SG11201604849YA (pt) |
WO (1) | WO2015092804A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2819286T3 (es) | 2014-08-16 | 2021-04-15 | Suven Life Sciences Ltd | Proceso para la producción a gran escala de oxalato de 1isopropil3{5[1(3metoxipropil) piperidin4il] [1,3,4]oxadiazol2il}1Hindazol |
RS59066B1 (sr) | 2015-02-13 | 2019-09-30 | Suven Life Sciences Ltd | Jedinjenja amida kao agonisti 5-ht4 receptora |
JP6900028B2 (ja) * | 2017-03-29 | 2021-07-07 | 国立大学法人帯広畜産大学 | パーキンソン病に併発した認知障害の治療剤 |
EP3628660A1 (en) * | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Donecopride and flucopride as neuroprotective agents in the treatment of neurodegenerative diseases |
EP4317141A1 (en) | 2022-08-04 | 2024-02-07 | Curia Spain S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708174A (en) | 1992-03-12 | 1998-01-13 | Smithkline Beecham P.L.C. | Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists |
WO1994010174A1 (en) | 1992-11-05 | 1994-05-11 | Smithkline Beecham Plc | Piperidine derivatives as 5-ht4 receptor antagonists |
JP2005526003A (ja) | 2001-10-22 | 2005-09-02 | ファイザー株式会社 | 5−ht4受容体調節剤としてのイミダゾピリジン化合物 |
CA2523077A1 (en) | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
CA2545092C (en) | 2003-11-24 | 2010-08-17 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
CA2551171C (en) * | 2003-12-23 | 2012-07-10 | Bio-Medisinsk Innovasjon As | Modulators of peripheral 5-ht receptors |
NZ555180A (en) * | 2004-12-22 | 2010-09-30 | Theravance Inc | Indazole-carboxamide compounds useful as 5-HT4 receptor agonists |
DK1856114T3 (en) | 2005-02-25 | 2014-11-17 | Raqualia Pharma Inc | Benzisoxazol-DERIVATIVES |
US7906532B2 (en) | 2005-07-22 | 2011-03-15 | Pfizer Inc. | Indazole derivatives |
WO2011099305A1 (en) | 2010-02-12 | 2011-08-18 | Raqualia Pharma Inc. | 5-ht4 receptor agonists for the treatment of dementia |
MX2012008721A (es) | 2010-02-16 | 2012-08-17 | Pfizer | (r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4. |
US9079894B2 (en) * | 2011-09-19 | 2015-07-14 | Suven Life Sciences Ltd | Heteroaryl compounds as 5-HT4 receptor ligands |
-
2014
- 2014-02-24 KR KR1020167015974A patent/KR101824154B1/ko active IP Right Grant
- 2014-02-24 EA EA201691252A patent/EA029951B1/ru unknown
- 2014-02-24 SG SG11201604849YA patent/SG11201604849YA/en unknown
- 2014-02-24 EP EP14725246.4A patent/EP3099675B1/en active Active
- 2014-02-24 CA CA2932428A patent/CA2932428C/en active Active
- 2014-02-24 US US15/104,521 patent/US9951045B2/en active Active
- 2014-02-24 JP JP2016539987A patent/JP6161823B2/ja active Active
- 2014-02-24 BR BR112016013974-7A patent/BR112016013974B1/pt active IP Right Grant
- 2014-02-24 AU AU2014369085A patent/AU2014369085B2/en not_active Ceased
- 2014-02-24 DK DK14725246.4T patent/DK3099675T3/en active
- 2014-02-24 NZ NZ720879A patent/NZ720879A/en not_active IP Right Cessation
- 2014-02-24 MX MX2016007857A patent/MX368017B/es active IP Right Grant
- 2014-02-24 ES ES14725246.4T patent/ES2668873T3/es active Active
- 2014-02-24 CN CN201480068132.6A patent/CN105873920B/zh active Active
- 2014-02-24 WO PCT/IN2014/000116 patent/WO2015092804A1/en active Application Filing
- 2014-02-24 AP AP2016009253A patent/AP2016009253A0/en unknown
-
2016
- 2016-05-31 IL IL245948A patent/IL245948B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DK3099675T3 (en) | 2018-05-22 |
CA2932428A1 (en) | 2015-06-25 |
MX368017B (es) | 2019-09-13 |
SG11201604849YA (en) | 2016-07-28 |
CN105873920B (zh) | 2018-06-08 |
KR20160075832A (ko) | 2016-06-29 |
IL245948B (en) | 2019-08-29 |
AU2014369085B2 (en) | 2017-02-23 |
NZ720879A (en) | 2017-05-26 |
AU2014369085A1 (en) | 2016-06-30 |
EA029951B1 (ru) | 2018-06-29 |
BR112016013974B1 (pt) | 2022-11-22 |
CN105873920A (zh) | 2016-08-17 |
AP2016009253A0 (en) | 2016-06-30 |
US20160311797A1 (en) | 2016-10-27 |
ES2668873T3 (es) | 2018-05-22 |
JP2016540796A (ja) | 2016-12-28 |
WO2015092804A1 (en) | 2015-06-25 |
JP6161823B2 (ja) | 2017-07-12 |
EP3099675A1 (en) | 2016-12-07 |
EA201691252A1 (ru) | 2016-12-30 |
EP3099675B1 (en) | 2018-02-14 |
KR101824154B1 (ko) | 2018-03-14 |
CA2932428C (en) | 2017-10-24 |
IL245948A0 (en) | 2016-08-02 |
MX2016007857A (es) | 2016-09-07 |
US9951045B2 (en) | 2018-04-24 |
BR112016013974A8 (pt) | 2018-01-30 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/02/2014, OBSERVADAS AS CONDICOES LEGAIS |