MX368004B - Análisis del transcriptoma de plasma materno mediante secuenciación de arn en paralelo a gran escala. - Google Patents
Análisis del transcriptoma de plasma materno mediante secuenciación de arn en paralelo a gran escala.Info
- Publication number
- MX368004B MX368004B MX2015010784A MX2015010784A MX368004B MX 368004 B MX368004 B MX 368004B MX 2015010784 A MX2015010784 A MX 2015010784A MX 2015010784 A MX2015010784 A MX 2015010784A MX 368004 B MX368004 B MX 368004B
- Authority
- MX
- Mexico
- Prior art keywords
- massively parallel
- maternal plasma
- rna sequencing
- transcriptome analysis
- parallel rna
- Prior art date
Links
- 230000008774 maternal effect Effects 0.000 title abstract 3
- 238000003559 RNA-seq method Methods 0.000 title 1
- 238000011222 transcriptome analysis Methods 0.000 title 1
- 230000001605 fetal effect Effects 0.000 abstract 2
- 230000035935 pregnancy Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere a métodos para el diagnóstico de trastornos relacionados con el embarazo, la determinación de relaciones alélicas, determinación de las contribuciones maternas o fetales con respecto a las transcripciones que circulan y/o la identificación de marcadores maternos o fetales utilizando una muestra de un sujeto femenino embarazado. También se proporciona el uso de un gen para el diagnóstico de un trastorno relacionado con el embarazo en un sujeto femenino embarazado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361770985P | 2013-02-28 | 2013-02-28 | |
PCT/IB2014/059351 WO2014132244A1 (en) | 2013-02-28 | 2014-02-28 | Maternal plasma transcriptome analysis by massively parallel rna sequencing |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015010784A MX2015010784A (es) | 2016-05-12 |
MX368004B true MX368004B (es) | 2019-09-13 |
Family
ID=51388739
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010784A MX368004B (es) | 2013-02-28 | 2014-02-28 | Análisis del transcriptoma de plasma materno mediante secuenciación de arn en paralelo a gran escala. |
MX2021015876A MX2021015876A (es) | 2013-02-28 | 2015-08-20 | Analisis del transcriptoma de plasma materno mediante secuenciacion de arn en paralelo a gran escala. |
MX2019010844A MX2019010844A (es) | 2013-02-28 | 2015-08-20 | Analisis del transcriptoma de plasma materno mediante secuenciacion de arn en paralelo a gran escala. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021015876A MX2021015876A (es) | 2013-02-28 | 2015-08-20 | Analisis del transcriptoma de plasma materno mediante secuenciacion de arn en paralelo a gran escala. |
MX2019010844A MX2019010844A (es) | 2013-02-28 | 2015-08-20 | Analisis del transcriptoma de plasma materno mediante secuenciacion de arn en paralelo a gran escala. |
Country Status (15)
Country | Link |
---|---|
US (3) | US10240199B2 (es) |
EP (4) | EP2961851B1 (es) |
JP (4) | JP6525894B2 (es) |
KR (2) | KR102082025B1 (es) |
CN (2) | CN109136364A (es) |
AU (4) | AU2014222312B2 (es) |
CA (2) | CA3117788A1 (es) |
EA (2) | EA202190075A3 (es) |
ES (1) | ES2670544T3 (es) |
HK (1) | HK1253097A1 (es) |
IL (4) | IL289547B2 (es) |
MX (3) | MX368004B (es) |
SG (2) | SG10201609080WA (es) |
TW (3) | TWI641834B (es) |
WO (1) | WO2014132244A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2961851B1 (en) * | 2013-02-28 | 2018-04-25 | The Chinese University Of Hong Kong | Maternal plasma transcriptome analysis by massively parallel rna sequencing |
CN105441432B (zh) * | 2014-09-05 | 2019-05-28 | 天津华大基因科技有限公司 | 组合物及其在序列测定和变异检测中的用途 |
CN104232778B (zh) * | 2014-09-19 | 2016-08-17 | 天津华大基因科技有限公司 | 同时确定胎儿单体型及染色体非整倍性的方法及装置 |
CN104232777B (zh) * | 2014-09-19 | 2016-08-24 | 天津华大基因科技有限公司 | 同时确定胎儿核酸含量和染色体非整倍性的方法及装置 |
WO2016205753A1 (en) * | 2015-06-17 | 2016-12-22 | The Translational Genomics Research Institute | Systems and methods for obtaining biological molecules from a sample |
NL2016967B1 (en) | 2016-06-15 | 2017-12-21 | Iq Products B V | Markers and their ratio to determine the risk for early-onset preeclampsia. |
CA3062985A1 (en) * | 2017-05-16 | 2018-11-22 | The Chinese University Of Hong Kong | Integrative single-cell and cell-free plasma rna analysis |
CN109280697B (zh) * | 2017-07-20 | 2022-04-26 | 天昊生物医药科技(苏州)有限公司 | 利用孕妇血浆游离dna进行胎儿基因型鉴定的方法 |
KR20200007035A (ko) | 2018-05-25 | 2020-01-21 | 일루미나, 인코포레이티드 | 자간전증에 특이적인 순환 rna 시그니처 |
CA3131748A1 (en) | 2019-11-22 | 2021-05-27 | Sarah E. SHULTZABERGER | Circulating rna signatures specific to preeclampsia |
KR102326813B1 (ko) * | 2020-04-20 | 2021-11-16 | 강원대학교산학협력단 | 임신중독증의 예측 또는 진단을 위한 바이오마커로서의 miRNA-214-3p 및 miRNA-1290-3p |
EP4165416A1 (en) | 2020-06-10 | 2023-04-19 | Board of Regents, The University of Texas System | Method for determining risk of pre-term birth |
KR102497167B1 (ko) * | 2020-11-04 | 2023-02-08 | 강원대학교산학협력단 | miR-155-5p 및 miR-1290-3p의 발현수준 비율을 이용한 임신중독증 진단 방법 |
KR102494583B1 (ko) * | 2020-11-04 | 2023-02-07 | 강원대학교산학협력단 | miR-31-5p 및 miR-1290-3p의 발현수준 비율을 이용한 임신중독증 진단 방법 |
US20230392207A1 (en) | 2022-06-03 | 2023-12-07 | Illumina, Inc. | Circulating rna biomarkers for preeclampsia |
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US6664056B2 (en) | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
CN100379882C (zh) | 2003-01-17 | 2008-04-09 | 香港中文大学 | 作为妊娠相关病症的诊断标志物的循环mRNA |
AU2003263660A1 (en) | 2003-08-29 | 2005-03-16 | Pantarhei Bioscience B.V. | Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood |
DK1804836T3 (da) * | 2004-09-24 | 2011-01-24 | Beth Israel Hospital | Fremgangsmåder til diagnosticering og behandling af graviditetskomplikationer |
JP5219516B2 (ja) * | 2005-03-18 | 2013-06-26 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 染色体異数性の検出方法 |
EP2612928A3 (en) * | 2005-03-18 | 2013-09-11 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
DE102005013949A1 (de) | 2005-03-26 | 2006-09-28 | Carl Zeiss Meditec Ag | Scanvorrichtung |
US7790463B2 (en) * | 2006-02-02 | 2010-09-07 | Yale University | Methods of determining whether a pregnant woman is at risk of developing preeclampsia |
US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
US20080233583A1 (en) * | 2007-02-20 | 2008-09-25 | Regents Of The University Of California | Biomarkers for preeclampsia |
EA035451B9 (ru) | 2007-07-23 | 2020-09-09 | Те Чайниз Юниверсити Ов Гонконг | Способ диагностики рака с использованием геномного секвенирования |
US20100016173A1 (en) | 2008-01-30 | 2010-01-21 | Proteogenix, Inc. | Maternal serum biomarkers for detection of pre-eclampsia |
KR101970908B1 (ko) | 2008-02-01 | 2019-04-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
WO2010033553A2 (en) * | 2008-09-16 | 2010-03-25 | University Of Florida Research Foundation Inc. | Gene expression related to preeclampsia |
CN101871002B (zh) * | 2009-04-22 | 2013-04-17 | 中山大学达安基因股份有限公司 | 一种无创性产前筛查21-三体综合征的试剂盒 |
CA2779695C (en) | 2009-11-05 | 2016-05-24 | The Chinese University Of Hong Kong | Fetal genomic analysis from a maternal biological sample |
US9260745B2 (en) * | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
EP2848704B1 (en) * | 2010-01-19 | 2018-08-29 | Verinata Health, Inc | Sequencing methods for prenatal diagnoses |
AU2011263306A1 (en) | 2010-06-07 | 2013-01-10 | Osnat Ashur-Fabian | Methods and kits for diagnosing conditions related to hypoxia |
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EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
WO2012058316A1 (en) * | 2010-10-26 | 2012-05-03 | Stanford University | Non-invasive fetal genetic screening by sequencing analysis |
AU2011348267A1 (en) * | 2010-12-23 | 2013-08-01 | Sequenom, Inc. | Fetal genetic variation detection |
US8530228B2 (en) | 2010-12-28 | 2013-09-10 | Bexmart | Integrated versatile and systems preparation of specimens |
WO2012093331A1 (en) * | 2011-01-05 | 2012-07-12 | The Chinese University Of Hong Kong | Noninvasive prenatal genotyping of fetal sex chromosomes |
EP2490027A1 (en) * | 2011-02-15 | 2012-08-22 | Roche Diagnostics GmbH | Means and methods for diagnosing pregnancy complications based on GDF-15 and PlGF/sFlt1 |
EP3489368B1 (en) | 2011-02-24 | 2020-09-09 | The Chinese University Of Hong Kong | Molecular testing of multiple pregnancies |
CN102286462A (zh) * | 2011-06-27 | 2011-12-21 | 深圳市易瑞生物技术有限公司 | 一种游离rna提取方法及试剂盒 |
EP2961851B1 (en) | 2013-02-28 | 2018-04-25 | The Chinese University Of Hong Kong | Maternal plasma transcriptome analysis by massively parallel rna sequencing |
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2014
- 2014-02-28 EP EP14757525.2A patent/EP2961851B1/en active Active
- 2014-02-28 ES ES14757525.2T patent/ES2670544T3/es active Active
- 2014-02-28 MX MX2015010784A patent/MX368004B/es active IP Right Grant
- 2014-02-28 CA CA3117788A patent/CA3117788A1/en active Pending
- 2014-02-28 EA EA202190075A patent/EA202190075A3/ru unknown
- 2014-02-28 SG SG10201609080WA patent/SG10201609080WA/en unknown
- 2014-02-28 IL IL289547A patent/IL289547B2/en unknown
- 2014-02-28 KR KR1020157022741A patent/KR102082025B1/ko active IP Right Grant
- 2014-02-28 EP EP19190836.7A patent/EP3587588B1/en active Active
- 2014-02-28 KR KR1020207004904A patent/KR102241051B1/ko active IP Right Grant
- 2014-02-28 CA CA2897684A patent/CA2897684C/en active Active
- 2014-02-28 EP EP21175354.6A patent/EP3910072A3/en active Pending
- 2014-02-28 CN CN201811106855.7A patent/CN109136364A/zh active Pending
- 2014-02-28 AU AU2014222312A patent/AU2014222312B2/en active Active
- 2014-02-28 EP EP18160528.8A patent/EP3351643B1/en active Active
- 2014-02-28 JP JP2015559600A patent/JP6525894B2/ja active Active
- 2014-02-28 US US14/194,294 patent/US10240199B2/en active Active
- 2014-02-28 WO PCT/IB2014/059351 patent/WO2014132244A1/en active Application Filing
- 2014-02-28 CN CN201480015402.7A patent/CN105143466B/zh active Active
- 2014-02-28 SG SG11201506516TA patent/SG11201506516TA/en unknown
- 2014-02-28 EA EA201591582A patent/EA037326B1/ru unknown
- 2014-03-03 TW TW103107127A patent/TWI641834B/zh active
- 2014-03-03 TW TW107135118A patent/TWI762728B/zh active
- 2014-03-03 TW TW111112400A patent/TWI801188B/zh active
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2015
- 2015-07-14 IL IL239939A patent/IL239939B/en active IP Right Grant
- 2015-08-20 MX MX2021015876A patent/MX2021015876A/es unknown
- 2015-08-20 MX MX2019010844A patent/MX2019010844A/es unknown
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2018
- 2018-09-28 HK HK18112484.8A patent/HK1253097A1/zh unknown
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2019
- 2019-01-23 US US16/255,745 patent/US11970742B2/en active Active
- 2019-05-07 JP JP2019087705A patent/JP2019162121A/ja active Pending
- 2019-07-04 IL IL267845A patent/IL267845B/en active IP Right Grant
- 2019-10-10 AU AU2019246833A patent/AU2019246833B2/en active Active
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2021
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- 2021-07-02 JP JP2021110946A patent/JP7397498B2/ja active Active
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2022
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2023
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- 2023-11-24 JP JP2023198942A patent/JP2024023390A/ja active Pending
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2024
- 2024-04-24 US US18/644,907 patent/US20240271218A1/en active Pending
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