EA201591582A1 - Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк - Google Patents

Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк

Info

Publication number
EA201591582A1
EA201591582A1 EA201591582A EA201591582A EA201591582A1 EA 201591582 A1 EA201591582 A1 EA 201591582A1 EA 201591582 A EA201591582 A EA 201591582A EA 201591582 A EA201591582 A EA 201591582A EA 201591582 A1 EA201591582 A1 EA 201591582A1
Authority
EA
Eurasian Patent Office
Prior art keywords
transcriptoma
sequency
rna
analysis
application
Prior art date
Application number
EA201591582A
Other languages
English (en)
Other versions
EA037326B1 (ru
Inventor
Юйк Мин Дэннис Ло
Росса Вай Квун Чиу
Квань Чэ Чань
Пэйюн Цзян
Бо Юин Цуи
Original Assignee
Те Чайниз Юниверсити Ов Гонконг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Те Чайниз Юниверсити Ов Гонконг filed Critical Те Чайниз Юниверсити Ов Гонконг
Publication of EA201591582A1 publication Critical patent/EA201591582A1/ru
Publication of EA037326B1 publication Critical patent/EA037326B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Предложены способы диагностики связанных с беременностью нарушений, определения аллельных отношений, определения вклада матери или плода в циркулирующие транскрипты и/или идентификации материнских или плодных маркеров с применением образца, полученного от субъекта - беременной женщины. Также предложено применение гена для диагностики связанного с беременностью нарушения у субъекта - беременной женщины.
EA201591582A 2013-02-28 2014-02-28 Способ анализа транскриптов материнской плазмы с применением массивного параллельного секвенирования рнк EA037326B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361770985P 2013-02-28 2013-02-28
PCT/IB2014/059351 WO2014132244A1 (en) 2013-02-28 2014-02-28 Maternal plasma transcriptome analysis by massively parallel rna sequencing

Publications (2)

Publication Number Publication Date
EA201591582A1 true EA201591582A1 (ru) 2015-12-30
EA037326B1 EA037326B1 (ru) 2021-03-12

Family

ID=51388739

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201591582A EA037326B1 (ru) 2013-02-28 2014-02-28 Способ анализа транскриптов материнской плазмы с применением массивного параллельного секвенирования рнк
EA202190075A EA202190075A3 (ru) 2013-02-28 2014-02-28 Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202190075A EA202190075A3 (ru) 2013-02-28 2014-02-28 Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк

Country Status (15)

Country Link
US (2) US10240199B2 (ru)
EP (4) EP3910072A3 (ru)
JP (4) JP6525894B2 (ru)
KR (2) KR102241051B1 (ru)
CN (2) CN109136364A (ru)
AU (4) AU2014222312B2 (ru)
CA (2) CA3117788A1 (ru)
EA (2) EA037326B1 (ru)
ES (1) ES2670544T3 (ru)
HK (1) HK1253097A1 (ru)
IL (4) IL289547B2 (ru)
MX (3) MX368004B (ru)
SG (2) SG10201609080WA (ru)
TW (3) TWI641834B (ru)
WO (1) WO2014132244A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368004B (es) * 2013-02-28 2019-09-13 Univ Hong Kong Chinese Análisis del transcriptoma de plasma materno mediante secuenciación de arn en paralelo a gran escala.
CN105441432B (zh) * 2014-09-05 2019-05-28 天津华大基因科技有限公司 组合物及其在序列测定和变异检测中的用途
CN104232778B (zh) * 2014-09-19 2016-08-17 天津华大基因科技有限公司 同时确定胎儿单体型及染色体非整倍性的方法及装置
CN104232777B (zh) * 2014-09-19 2016-08-24 天津华大基因科技有限公司 同时确定胎儿核酸含量和染色体非整倍性的方法及装置
WO2016205753A1 (en) * 2015-06-17 2016-12-22 The Translational Genomics Research Institute Systems and methods for obtaining biological molecules from a sample
NL2016967B1 (en) 2016-06-15 2017-12-21 Iq Products B V Markers and their ratio to determine the risk for early-onset preeclampsia.
WO2018210275A1 (en) * 2017-05-16 2018-11-22 The Chinese University Of Hong Kong Integrative single-cell and cell-free plasma rna analysis
CN109280697B (zh) * 2017-07-20 2022-04-26 天昊生物医药科技（苏州）有限公司 利用孕妇血浆游离dna进行胎儿基因型鉴定的方法
AU2019275457B2 (en) * 2018-05-25 2021-11-04 Illumina, Inc. Circulating RNA signatures specific to preeclampsia
CA3131748A1 (en) 2019-11-22 2021-05-27 Sarah E. SHULTZABERGER Circulating rna signatures specific to preeclampsia
KR102326813B1 (ko) * 2020-04-20 2021-11-16 강원대학교산학협력단 임신중독증의 예측 또는 진단을 위한 바이오마커로서의 miRNA-214-3p 및 miRNA-1290-3p
US20230236203A1 (en) 2020-06-10 2023-07-27 Board Of Regents, The University Of Texas System Method for Determining Risk of Pre-Term Birth
KR102497167B1 (ko) * 2020-11-04 2023-02-08 강원대학교산학협력단 miR-155-5p 및 miR-1290-3p의 발현수준 비율을 이용한 임신중독증 진단 방법
KR102494583B1 (ko) * 2020-11-04 2023-02-07 강원대학교산학협력단 miR-31-5p 및 miR-1290-3p의 발현수준 비율을 이용한 임신중독증 진단 방법
US20230392207A1 (en) 2022-06-03 2023-12-07 Illumina, Inc. Circulating rna biomarkers for preeclampsia

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664056B2 (en) * 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
CN101245376A (zh) * 2003-01-17 2008-08-20 香港中文大学 作为妊娠相关病症的诊断标志物的循环mRNA
AU2003263660A1 (en) * 2003-08-29 2005-03-16 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
JP5270161B2 (ja) * 2004-09-24 2013-08-21 ベス イスラエル デアコネス メディカル センター 妊娠合併症を診断および処置する方法
CA3007182A1 (en) 2005-03-18 2006-09-21 The Chinese University Of Hong Kong Markers for prenatal diagnosis, monitoring or predicting preeclampsia
AU2006224971B2 (en) * 2005-03-18 2009-07-02 Boston University A method for the detection of chromosomal aneuploidies
DE102005013949A1 (de) 2005-03-26 2006-09-28 Carl Zeiss Meditec Ag Scanvorrichtung
US7790463B2 (en) * 2006-02-02 2010-09-07 Yale University Methods of determining whether a pregnant woman is at risk of developing preeclampsia
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US20080233583A1 (en) * 2007-02-20 2008-09-25 Regents Of The University Of California Biomarkers for preeclampsia
CA3176319A1 (en) * 2007-07-23 2009-01-29 The Chinese University Of Hong Kong Analyzing tumor dna in a cell-free sample
US20100016173A1 (en) 2008-01-30 2010-01-21 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia
CA2713909C (en) * 2008-02-01 2023-12-12 The General Hospital Corporation Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions
WO2010033553A2 (en) * 2008-09-16 2010-03-25 University Of Florida Research Foundation Inc. Gene expression related to preeclampsia
CN101871002B (zh) * 2009-04-22 2013-04-17 中山大学达安基因股份有限公司 一种无创性产前筛查21-三体综合征的试剂盒
HUE034854T2 (en) 2009-11-05 2018-03-28 Univ Hong Kong Chinese Fetal genomic analysis from maternal biological samples
US9260745B2 (en) * 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
EP2848703A1 (en) 2010-01-19 2015-03-18 Verinata Health, Inc Simultaneous determination of aneuploidy and fetal fraction
MX2012014284A (es) 2010-06-07 2013-04-29 Osnat Ashur-Fabian Metodos y kits para diagnosticar afecciones relacionadas con hipoxia.
US20120077185A1 (en) 2010-08-06 2012-03-29 Tandem Diagnostics, Inc. Detection of genetic abnormalities and infectious disease
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
EP2633311A4 (en) * 2010-10-26 2014-05-07 Univ Stanford NON-INVASIVE F TAL GENE SCREENING BY SEQUENCING ANALYSIS
CN103384725A (zh) * 2010-12-23 2013-11-06 塞昆纳姆股份有限公司 胎儿遗传变异的检测
US8530228B2 (en) 2010-12-28 2013-09-10 Bexmart Integrated versatile and systems preparation of specimens
US10152568B2 (en) * 2011-01-05 2018-12-11 The Chinese University Of Hong Kong Noninvasive prenatal genotyping of fetal sex chromosomes
EP2490027A1 (en) * 2011-02-15 2012-08-22 Roche Diagnostics GmbH Means and methods for diagnosing pregnancy complications based on GDF-15 and PlGF/sFlt1
CN103492589B (zh) * 2011-02-24 2016-06-15 香港中文大学 多胎妊娠的分子测试
CN102286462A (zh) * 2011-06-27 2011-12-21 深圳市易瑞生物技术有限公司 一种游离rna提取方法及试剂盒
MX368004B (es) * 2013-02-28 2019-09-13 Univ Hong Kong Chinese Análisis del transcriptoma de plasma materno mediante secuenciación de arn en paralelo a gran escala.

Also Published As

Publication number Publication date
TW201900882A (zh) 2019-01-01
AU2014222312B2 (en) 2019-08-01
EP3587588B1 (en) 2021-06-30
TWI762728B (zh) 2022-05-01
IL289547B2 (en) 2024-01-01
IL289547A (en) 2022-03-01
AU2022200046A1 (en) 2022-02-03
AU2022200046B2 (en) 2022-11-17
CA2897684C (en) 2021-06-29
EP3910072A2 (en) 2021-11-17
EP2961851B1 (en) 2018-04-25
AU2019246833B2 (en) 2021-10-07
AU2019246833A1 (en) 2019-10-31
MX368004B (es) 2019-09-13
EA202190075A3 (ru) 2021-07-30
IL239939B (en) 2019-07-31
CN109136364A (zh) 2019-01-04
WO2014132244A9 (en) 2014-11-27
JP2024023390A (ja) 2024-02-21
CA3117788A1 (en) 2014-09-04
JP7397498B2 (ja) 2023-12-13
IL281429A (en) 2021-04-29
EP2961851A1 (en) 2016-01-06
US10240199B2 (en) 2019-03-26
CN105143466A (zh) 2015-12-09
ES2670544T3 (es) 2018-05-30
KR20200020996A (ko) 2020-02-26
EA037326B1 (ru) 2021-03-12
US20190218615A1 (en) 2019-07-18
TWI641834B (zh) 2018-11-21
US20140243212A1 (en) 2014-08-28
EP3910072A3 (en) 2022-02-16
MX2015010784A (es) 2016-05-12
JP2016511641A (ja) 2016-04-21
EP2961851A4 (en) 2016-11-16
US11970742B2 (en) 2024-04-30
TWI801188B (zh) 2023-05-01
IL267845B (en) 2021-04-29
WO2014132244A1 (en) 2014-09-04
AU2023200786A1 (en) 2023-03-09
TW202246521A (zh) 2022-12-01
MX2021015876A (es) 2022-02-03
SG11201506516TA (en) 2015-09-29
SG10201609080WA (en) 2016-12-29
EP3587588A1 (en) 2020-01-01
AU2014222312A1 (en) 2015-07-30
KR102082025B1 (ko) 2020-02-26
EP3351643B1 (en) 2019-09-18
JP2021164469A (ja) 2021-10-14
MX2019010844A (es) 2019-10-30
KR102241051B1 (ko) 2021-04-16
IL267845A (en) 2019-09-26
KR20150123807A (ko) 2015-11-04
CA2897684A1 (en) 2014-09-04
IL289547B1 (en) 2023-09-01
JP6525894B2 (ja) 2019-06-05
TW201441618A (zh) 2014-11-01
IL281429B (en) 2022-02-01
EA202190075A2 (ru) 2021-04-30
EP3351643A1 (en) 2018-07-25
JP2019162121A (ja) 2019-09-26
HK1253097A1 (zh) 2019-06-06
IL239939A0 (en) 2015-08-31
CN105143466B (zh) 2018-10-23

Similar Documents

Publication Publication Date Title
EA201591582A1 (ru) Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк
BR112014026661A2 (pt) método in vitro para diagnóstico e vigilância do câncer
CY1118864T1 (el) Μεθοδοι και συνθεσεις για μη επεμβατικη προγεννητικη διαγνωση εμβρυϊκων ανευπλοειδιων
MX2018008421A (es) Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.
BR112015032031A8 (pt) método para estimar uma fração de ácido nucleico em uma amostra de teste de uma mulher grávida
MX2013000457A (es) Metodo para evaluar el riesgo de nacimientos multiples en tratamientos de infertilidad.
JP2014533509A5 (ru)
WO2015094996A3 (en) Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
BR112015024110A2 (pt) método de detecção de um distúrbio de gravidez ou aneuploidia fetal até o segundo trimestre
EP2909315A4 (en) DETECTION AND ANALYSIS OF FETAL TROPHOBLASTIC CELLS IN THE NUTRIMAL SLEEVE FOR PRENATAL DIAGNOSIS
EA201691352A1 (ru) Диагностика рака легкого с помощью циркулирующих опухолевых клеток
EP3159695A3 (en) Methods for diagnosing pancreatic cancer
MX2015015687A (es) Diagnostico fetales que usa captura de celulas fetales de sangre materna.
BR112015027249A2 (pt) método de diagnóstico de câncer
MX2016007148A (es) Metodos de ensayo de beta-glucano.
EA201800130A1 (ru) Способ оценки функционального состояния плода во втором триместре беременности методом кардиотокографии
RU2012113509A (ru) Способ прогнозирования плацентарной недостаточности у беременных женщин с поздним менархе с помощью метода дискриминантного анализа
RU2014106437A (ru) Способ определения клинического варианта эутиреоза и гипотиреоза
UA83453U (ru) Способ диагностики эндогенной интоксикации у больных с ишемической болезнью сердца после хирургического вмешательства
Norets Le Сarre’s Spy Novel in the Literature of the Cold War
RU2011100706A (ru) Способ подготовки беременных к родам
Duan et al. Clinical indications and detection efficiency of non-invasive prenatal testing in 13 041 cases from Jiangsu Province, China
RU2013149755A (ru) Способ прогнозирования состояния венозного оттока из сосудов мозга у больных гриппом
UA81832U (ru) Способ определения продолжительности проведения иммунокоррекции зависимости от степени стрессированности животного
UA92385U (ru) Способ диагностики и прогнозирования задержки внутриутробного развития плода по показателям функционального состояния генома нейтрофилов периферической крови беременных женщин