WO2013050383A3 - In vitro method to determine the risk of a pregnant woman of carrying a fetus with fetal aneuploidy - Google Patents

In vitro method to determine the risk of a pregnant woman of carrying a fetus with fetal aneuploidy Download PDF

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Publication number
WO2013050383A3
WO2013050383A3 PCT/EP2012/069489 EP2012069489W WO2013050383A3 WO 2013050383 A3 WO2013050383 A3 WO 2013050383A3 EP 2012069489 W EP2012069489 W EP 2012069489W WO 2013050383 A3 WO2013050383 A3 WO 2013050383A3
Authority
WO
WIPO (PCT)
Prior art keywords
fetus
pregnant woman
risk
carrying
fetal aneuploidy
Prior art date
Application number
PCT/EP2012/069489
Other languages
French (fr)
Other versions
WO2013050383A2 (en
Inventor
Gaiané DEMIRDJIAN
Bruno Darbouret
Original Assignee
Cezanne S.A.S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cezanne S.A.S filed Critical Cezanne S.A.S
Publication of WO2013050383A2 publication Critical patent/WO2013050383A2/en
Publication of WO2013050383A3 publication Critical patent/WO2013050383A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies
    • G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the risk assessment of fetal aneuploidy in a fetus determination of paraoxonase 1 (PON-1) in a sample obtained from a pregnant woman.
PCT/EP2012/069489 2011-10-04 2012-10-02 In vitro method to determine the risk of a pregnant woman of carrying a fetus with fetal aneuploidy WO2013050383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11290461.0 2011-10-04
EP11290461 2011-10-04

Publications (2)

Publication Number Publication Date
WO2013050383A2 WO2013050383A2 (en) 2013-04-11
WO2013050383A3 true WO2013050383A3 (en) 2013-06-06

Family

ID=46963762

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/069489 WO2013050383A2 (en) 2011-10-04 2012-10-02 In vitro method to determine the risk of a pregnant woman of carrying a fetus with fetal aneuploidy

Country Status (1)

Country Link
WO (1) WO2013050383A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201522665D0 (en) * 2015-12-22 2016-02-03 Premaitha Ltd Detection of chromosome abnormalities

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100216250A1 (en) * 2009-02-20 2010-08-26 Lopez Mary Frances Methods for Predicting Trisomy 21 in a Fetus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100216250A1 (en) * 2009-02-20 2010-08-26 Lopez Mary Frances Methods for Predicting Trisomy 21 in a Fetus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "For the development of sandwich ELISAs to measure Paraoxonase/Arylesterase 1 (PON1) in cell lysates.", R&D SYSTEMS CATALOG, 11 February 2011 (2011-02-11), pages 1 - 11, XP055019789, Retrieved from the Internet <URL:http://www.rndsystems.com/pdf/DYC5816.pdf> [retrieved on 20120220] *
JANEL N ET AL: "Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 346, no. 4, 11 August 2006 (2006-08-11), pages 1303 - 1306, XP024925455, ISSN: 0006-291X, [retrieved on 20060811], DOI: 10.1016/J.BBRC.2006.06.048 *
ROSENBLAT M ET AL: "Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relevance to diabetes", ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, IE, vol. 187, no. 1, 1 July 2006 (2006-07-01), pages 74.E1 - 74.E10, XP028071412, ISSN: 0021-9150, [retrieved on 20060701], DOI: 10.1016/J.ATHEROSCLEROSIS.2005.08.026 *

Also Published As

Publication number Publication date
WO2013050383A2 (en) 2013-04-11

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